22955-73-3Relevant articles and documents
Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes
Yu, Congjun,?zkaya, Bünyamin,Patureau, Frederic W.
supporting information, p. 3682 - 3687 (2021/02/01)
A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool.
Preparation method of picotamide
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Paragraph 0027; 0031-0033, (2021/01/25)
The invention provides a method for preparing picotamide, which comprises the following steps: taking dimethyl 4-hydroxyl isophthalate as a raw material, carrying out methyl etherification reaction toobtain dimethyl 4-methoxy isophthalate; then, carrying out hydrolysis reaction to obtain 4-methoxy isophthalic acid; and finally, carrying out amidation reaction to obtain picotamide. Compared with atraditional method, the preparation method has the advantages of short synthesis steps, simplicity and convenience in operation, high reaction speed, high yield and the like. Besides, the raw materials required by the method are extracted from waste residues generated in industrial production, the extraction method is simple, the resource utilization rate is increased, the environmental pollutionis reduced, the production cost is reduced, and the method is suitable for large-scale industrial production.
"Compound for the treatment of atherosclerotic-thrombotic pathological conditions"
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, (2008/06/13)
4-Methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide of following formula 1: and acid addition salts thereof with pharmaceutically acceptable organic and inorganic acids, and a pharmaceutical composition containing the same, for the treatment of vascular diseases involving atherosclerotic-thrombotic conditions and of other pathological conditions as shown in the description.
Alkyliron and Alkylcobalt Reagents, VIII. - Alkyl-Iron(II) Compounds as Reagents and Catalysts for the Transformation of Acyl Chlorides into Ketones
Kauffmann, Thomas,Voss, Karl-Uwe,Neiteler, Gabriele
, p. 1453 - 1460 (2007/10/02)
Me2Fe, Bu2Fe, Me3FeLi, or Bu3FeLi - prepared in situ by reduction of FeCl3 to FeCl2 and subsequent alkylation with MeLi, MeMgBr, BuLi, or BuMgBr - are useful reagents for the conversion of acyl chlorides into ketones.The system (RMgX + catalytic amount of FeCl3) react like the FeII reagents with acyl chlorides to give ketones even at -65 deg C.Competition experiments with benzoyl chloride/2-methoxybenzoyl chloride show that the selectivity increases (competition constants Kk = 9.9, 10.7, 10.9, 15.0, ca. 110) in the sequence MeFeCl, Me2Fe, Me3Fe(MgBr), Me4Fe(MgBr)2, and catalytic system (MeMgBr + 2.5 mol percent FeCl3) (= 2, 3, 4, 5, and 40MeMgBr per 1 FeCl3, respectively).A new hypothesis on the nature of the active catalyst is discussed. Key Words: Organoiron compounds / Iron catalysts / Ketone synthesis
Structures of ent-Herbertane Sesquiterpenoids displaying Antifungal Properties from the Liverwort Herberta adunca
Matsua, Akihiko,Yuki, Shunji,Nakayama, Mitsuru
, p. 701 - 710 (2007/10/02)
Several aromatic sesquiterpenoids displaying antifungal propaerties have been isolated from the liverwort Herberta adunca together with a mother hydrocarbon with a novel irregular sesquiterpene skeleton, ent-herbertane, and their structures and absolute configurations have been determined on the basis of extensive degradation reactions and spectroscopic evidence.The biological activity is also described.
THREE NEW SESQUITERPENE PHENOLS OF THE ENT-HERBERTANE CLASS FROM THE LIVERWORT HERBERTA ADUNCA
Matsuo, Akihiko,Yuki, Shunji,Nakayama, Mitsuru,Hayashi, Shuichi
, p. 463 - 466 (2007/10/02)
Three sesquiterpene phenols with an ent-herberatne skeleton have been isolated from the liverworth Herberta adunca, and the alucidation of their structures and absolue configurations has been achieved on the basis of the chemical and spectral evidence.
THE STRUCTURE, ABSOLUTE CONFIGURATION AND BIOSYNTHESIS OF NORTILIACORININE A
Bhakuni, Dewan S,Singh, Awadhesh,Jain, Sudha
, p. 2651 - 2655 (2007/10/02)
The incorporation of (+/-)-norcoclaurine, (+/-)-coclaurine, (+/-)-N-methylcoclaurine and dehydro-N-methylcoclaurine into nortiliacorinine A in Tilicora racemosa colebr has been studied and specific utilisation of the (+/-)-coclaurine demonstrated.The evidence supports oxidative dimerization of two coclaurine units to give nortiliacorinine A.Experiments with (+/-)-N-methylcoclaurine and (+/-)-N-methylcoclaurine established that only one N-methylcoclaurine unit is specifically utilised to constitute that the H atom at the asymmetric centre in the 1-benzylisoquinoline precursor is retained in the bioconversion into nortiliacorine A.Double labelling experiment with (+/-)-N-methylcoclaurine showed that O-Me function of the precursor is lost in the bioconversion into nortiliacorine A.Parallel feedings of (+)-(S)-, and (-)-(R)-N-methyl-coclaurines and (-)-(S)-, and (+)-(R)-coclaurines revealed that the stereo-specificity is maintained in the biosynthesis of nortiliacorinine A from 1-benzylisoquinoline precursors and established S,S'-configuration at the two asymmetric centres in nortiliacorinine A.
