2403-53-4

Basic information

• Product Name: 2-(4-nitrophenyl)-1,3-dioxolane
• Synonyms: 2-(p-Nitrophenyl)-1,3-dioxolane;4-Nitrobenzaldehyde ethylene acetal;2-(4-Nitrophenyl)-1,3-dioxolane 97%
• CAS NO: 2403-53-4
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.18
• Mol File: 2403-53-4.mol

Chemical Properties

• Melting Point: 90.5 °C
• Boiling Point: 332.9 °C at 760 mmHg
• Flash Point: 164.7 °C
• Appearance: /
• Density: 1.329 g/cm³
• Vapor Pressure: 0.000273mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-nitrophenyl)-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)-1,3-dioxolane(2403-53-4)
• EPA Substance Registry System: 2-(4-nitrophenyl)-1,3-dioxolane(2403-53-4)

Safety Data

• Hazardous Substances Data: 2403-53-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-nitrophenyl)-1,3-dioxolane is used as a solvent in the pharmaceutical industry for its ability to dissolve a wide range of compounds, facilitating the manufacturing and formulation of various drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(4-nitrophenyl)-1,3-dioxolane serves as a solvent, aiding in the production and application of agricultural chemicals to enhance crop protection and yield.
Used in Electronics Industry:
2-(4-nitrophenyl)-1,3-dioxolane is utilized as a solvent in the electronics industry, where it plays a role in the manufacturing processes of electronic components and devices, contributing to their functionality and performance.
Used as a Reagent in Organic Synthesis:
2-(4-nitrophenyl)-1,3-dioxolane is employed as a reagent in organic synthesis, enabling the formation of various complex organic molecules for use in different chemical and industrial applications.
Used as an Intermediate in Chemical Production:
2-(4-nitrophenyl)-1,3-dioxolane also functions as an intermediate in the production of other chemicals, highlighting its versatility and importance in the chemical industry.

InChI:InChI=1/C9H9NO4/c11-10(12)8-3-1-7(2-4-8)9-13-5-6-14-9/h1-4,9H,5-6H2

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 107-21-1 ethylene glycol 
• 111-90-0 ethoxyethoxyethanol 
• 39184-67-3 3-chloro-3-(p-nitrophenyl)diazirine 
• 2916-31-6 2,2-dimethyl-1,3-dioxolane 
• 22391-06-6 2-(4-nitrophenyl)-1,3-oxathiolane 
• 108212-53-9 2-<(4-nitrophenyl)methoxy>ethanol 
• 619-73-8 4-nitrobenzyl chloride 
• 7381-30-8 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane 
• 2403-62-5 p-nitrobenzaldehyde diethyl acetal 
• 75-21-8 oxirane 
• 149-73-5 trimethyl orthoformate 
• 881-67-4 4-nitrobenzaldehyde dimethyl acetal 

Downstream Products

• 19073-14-4 4-(1,3-dioxolan-2-yl)aniline 
• 23574-40-5 2-bromoethyl 4-nitrobenzoate 
• 89303-15-1 2-(3-Benzenesulfonylmethyl-4-nitro-phenyl)-[1,3]dioxolane 
• 148582-48-3 2-(2-methyl-4-nitrophenyl)-1,3-dioxolane 
• 10516-12-8 2-hydroxyethyl 4-nitrobenzoate 
• 555-16-8 4-nitrobenzaldehdye 
• 108212-53-9 2-<(4-nitrophenyl)methoxy>ethanol 
• 99-77-4 ethyl 4-nitrobenzoate 
• 619-72-7 4-nitrobenzonitrile 
• 1129-37-9 4-nitrobenzaldehyde oxime 
• 62-23-7 4-nitro-benzoic acid 
• 37104-08-8 5-(1,3-dioxolan-2-yl)-3-phenyl-2,1-benzisoxazole 
• 41159-02-8 2-(4-nitrophenyl)-1,3-dithiolane 
• 23837-16-3 ((4-nitrophenyl)methylene)bis(phenylsulfane) 

Relevant articles and documents

Real-time mechanistic monitoring of an acetal hydrolysis using ultrafast 2D NMR

Ultrafast (UF) 2D NMR makes it possible to obtain a 2D NMR spectrum in less than a second. Here, UF-HSQC experiments are used for the real-time mechanistic study of an acetal hydrolysis at 13C natural abundance, and it is possible to characterize the presence of the hemiacetal, an intermediate with a well-known short lifetime. The assignments are confirmed and rationalized by quantum calculations of 1H and 13C NMR chemical shifts and natural bonding orbital analysis. Copyright

Application of poly(Vinylbenzyltrimethylammonium tribromide) resin as an efficient polymeric catalyst in the acetalization and diacetylation of benzaldehydes

The applications of a new supported tribromide reagent (poly(vinylbenzyltrimethylammonium tribromide) resin) were reported. This supported tribromide resin was used as a catalyst in the acetalization and diacetylation of benzaldehydes under mild conditions with high efficiency. The effects of solvents, and amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, most of acetal and 1,1-diacetates of benzaldehydes were selectively obtained in excellent yields.

Discovery of tert-amine-based RORγt agonists

The nuclear receptor retinoic acid receptor-related orphan receptor gamma-t (RORγt) is a transcription factor regulating Th17 cell differentiation and proliferation from naive CD4+ T cells. Since Th17 cells have demonstrated the antitumor efficacy by eliciting remarkable activation of CD8+ T cells, RORγt agonists could be applied as potential small molecule therapeutics for cancer immunotherapy. Based on the previously reported RORγt agonist 1 and its resolved co-crystal structure, a series of new tertiary amines were designed, synthesized and biologically evaluated, yielding optimal moieties with improved chemical properties and biological responses. The combination of these optimal moieties resulted in identification of novel RORγt agonists such as 8b with further elevated RORγt agonism responses at a target-based level as well as in cell-based assays, which provided some structural knowledge for further optimization of RORγt agonists as small molecule therapeutics for cancer immunotherapy.

Practical acetalization and transacetalization of carbonyl compounds catalyzed by recyclable PVP-I

A novel PVP-I catalyzed acetalizations/transacetalizations of carbonyl compounds has been developed processing with a mild and easy handling fashion. Different types of Acyclic and cyclic acetals were prepared from carbonyl compounds or their acetals successfully. Further applications of newly developed catalytic combination were testified. This protocol featured with simplicity of operation, mild reaction condition, short reaction time, recyclable of catalyst and broad substrates scope with excellent yields.

Catalytic application of sulfamic acid-functionalized magnetic Fe3O4nanoparticles (SA-MNPs) for protection of aromatic carbonyl compounds and alcohols: Experimental and theoretical studies

Protection techniques of functional groups within the structure of organic compounds are important synthetic methods against unwanted attacks from various reagents during synthetic sequences. Acetal and thioacetal groups are well known as protective funct

Preparation method of acetal or ketal compound

The invention discloses a preparation method of an acetal or ketal compound. The preparation method comprises the following steps: oscillating aldehyde or ketone, alcohol and a catalyst at 60 DEG C, and carrying out post-treatment after the reaction is finished to obtain the acetal compound, wherein the catalyst comprises alpha-chymotrypsin, the aldehyde or ketone has a structure represented by acompound A, R1 and R2 are respectively and independently selected from aryl, H and alkyl, the alcohol has a structure represented by a compound B, and R3 is selected from saturated alkane. The preparation method provided by the invention is catalyzed by alpha-chymotrypsin, is mild in reaction condition, simple in operation process, low in cost and environment-friendly, and has popularization and application values.

α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols

This is the first report of a simple and general method for acetalization of aldehydes via an α-chymotrypsin-induced reaction under mild conditions. A broad range of aromatic and heteroaromatic aldehydes have been acetalized under neutral conditions in good yields using a catalytic amount of chymotrypsin.

Cage structure helps to improve the photoisomerization efficiency of azobenzene

Azobenzene (Azo) usually cannot achieve relatively high photoisomerization efficiency because of the overlap of the n-π* absorption bands between their isomers. In this work, three Azo units were integrated into a cage (AC) and adopt a nonplanar configura

Palladium-Catalyzed Mizoroki-Heck Reaction of Nitroarenes and Styrene Derivatives

We have developed a Mizoroki-Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. The combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multifunctionalized arene in a one-pot operation.

Tertiary amine derivative or salt thereof, preparation method and application thereof

Belonging to the technical field of chemical medicine, the invention relates to a tertiary amine RORgamma t regulator, in particular to a new tertiary amine compound or salt thereof with RORgamma t inhibition or agonist activity shown as general formula I, a preparation method and a pharmaceutical composition thereof. The tertiary amine compound or a salt thereof provided by the invention can be used for preparation of drugs treating or preventing RORgamma t receptor related diseases.