24242-20-4

Basic information

• Product Name: 5-Amino-2-pyridinecarboxylic acid
• Synonyms: 5-amino-2-pyridinecarboxylicaci;RARECHEM AL BO 1485;2-PYRIDINECARBOXYLIC ACID, 5-AMINO-;5-AMINO-2-PYRIDINECARBOXYLIC ACID;5-AMINO-2-PICOLINIC ACID;5-AMINOPYRIDINE-2-CARBOXYLIC ACID;5-AMINOPICOLINIC ACID;2-Pyridinecarboxylicacid,5-amino-(9CI)
• CAS NO: 24242-20-4
• Molecular Formula: C₆H₆N₂O₂
• Molecular Weight: 138.12
• Product Categories: AMINOACID;pyridines;pharmacetical;Pyridine series;Carboxylic Acids;Aromatics Compounds;pyridine;Aromatics;Carboxylic Acids;Heterocycle-Pyridine series
• Mol File: 24242-20-4.mol

Chemical Properties

• Melting Point: 222-223
• Boiling Point: 420.758 °C at 760 mmHg
• Flash Point: 208.267 °C
• Appearance: Plates
• Density: 1.417 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.649
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Acetone, Ethanol, Methanol
• PKA: 1.33±0.50(Predicted)
• CAS DataBase Reference: 5-Amino-2-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-pyridinecarboxylic acid(24242-20-4)
• EPA Substance Registry System: 5-Amino-2-pyridinecarboxylic acid(24242-20-4)

Safety Data

• Hazard Codes: Xi,T,Xn
• Statements: 23/24/25-36/37/38-22
• Safety Statements: 26-36/37/39-45-37
• WGK Germany: 3
• TSCA: N
• HazardClass: IRRITANT
• Hazardous Substances Data: 24242-20-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Amino-2-pyridinecarboxylic acid is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its presence in the molecular structure of these compounds can contribute to their biological activity and therapeutic effects.
Used in Chemical Industry:
In the chemical industry, 5-Amino-2-pyridinecarboxylic acid is utilized as a building block for the synthesis of a wide range of chemical products, including dyes, pigments, and other specialty chemicals. Its reactivity and functional groups make it a versatile component in the creation of complex molecules.
Used in Research and Development:
5-Amino-2-pyridinecarboxylic acid is also employed in research and development settings, where it is used to study the properties and reactivity of pyridine-based compounds. This knowledge can be applied to the design and synthesis of new molecules with potential applications in various fields, such as materials science, agrochemistry, and medicinal chemistry.

InChI:InChI=1/C6H6N2O2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,7H2,(H,9,10)

Upstream product

• 30651-24-2 5-nitropicolinic acid 
• 4487-59-6 2-bromo-5-nitropyridine 
• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 100367-55-3 5-nitropyridine-2-carbonitrile 
• 59290-34-5 5-nitropyridine-2-carboxamide 
• 55338-73-3 5-amino-2-cyanopyridine 

Downstream Products

• 86873-62-3 5-Acetylaminopyridin-2-carbonsaeure 
• 15069-92-8 5-hydroxypicolinic acid 
• 30766-11-1 5-bromoisonicotinic acid 
• 32046-43-8 5-Iodpicolinsaeure 
• 29082-92-6 5-methoxypyridine-2-carboxylic acid 
• 67515-76-8 methyl 5-amino-2-pyridinecarboxylate 
• 119830-47-6 ethyl 3-amino-pyridine-6-carboxylate 
• 145255-19-2 5-aminopyridine-2-carboxylic acid amide 
• 929300-19-6 6-({9-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-3,9-diazaspiro[5.5]undec-3-yl}carbonyl)pyridin-3-amine 
• 323578-38-7 tert-butyl N-[6-(hydroxymethyl)pyridin-3-yl]carbamate 
• 1078129-19-7 ethyl 5-(tert-butoxycarbonylamino)picolinate 
• 1203486-73-0 tert-butyl 6-(morpholinomethyl)pyridin-3-ylcarbamate 
• 1208331-17-2 C₂₅H₁₉N₃O₃ 
• 873651-92-4 (5-aminopyridin-2-yl)methanol 

Relevant articles and documents

NEW BICYCLIC DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES

The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

The effect of dye structure on the dyeing and optical properties of dichroic dyes for PVA polarizing film

The dyeing behaviour and optical properties of four novel dyes in PVA polarizing films were determined in terms of the linearity, hydrogen bonding ability, intermolecular interaction and transition moment. The linearity and H-bonding ability of the dyes w

IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula ( I ) represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

AZAINDOLE DERIVATIVES AS INHIBITORS OF P38 KINASE

The invention is directed to methods to inhibit p38 kinase, preferably p38-α using compounds which are azaindoles wherein the azaindoles are coupled through an azacyclic linker to another cyclic moiety.

Comparison of two synthetic methods to obtain [18F] N-(2-aminoethyl)-5-fluoropyridine-2-carboxamide, a potential MAO-B imaging tracer for PET

The compound Ro 19-6327, N-(2-aminoethyl)-5-chloropyridine-2-carboxamide, is known to inhibit reversibly and site specifically the enzyme monoamine oxidase B (MAO-B). The 123I-labelled iodo-analogue N-(2-aminoethyl)-5-iodopyridine-2-carboxamide (Ro 43-0463) was investigated successfully in human volunteers by means of SPET (Single Photon Emission Tomography). We developed therefore the synthesis and radiolabelling of the corresponding fluoro-analogue N-(2-aminoethyl)-5-fluoropyridine-2-carboxamide with 18F in order to carry out PET (Position Emission Tomography) investigations of MAO-B related neuropsychiatric diseases. For this purpose two synthetic approaches leading to the electrophilic and the nucleophilic methods of 18F radiolabelling were undertaken. The nucleophilic approach appeared to be superior when factors such as precursor synthesis, beam time, specific activity and radiochemical purity of the product are considered.

Aminopyridine compounds

An aminopyridine compound represented by the formula: STR1 wherein n represents 0 or 1; Z represents =S, =O, =NCN or =CHNO2 ; R1 represents --CN, --NR3 R4, --CONR3 R4, --NHNR3 R4, --NHCONHR3, --NHSO2 R3 or --SR3 ; R2 represents H, or substituted or unsubstituted alkyl; R3 and R4, which may be the same or different, represent H, substituted or unsubstituted alkyl, aryl, substituted or unsubstituted acyl or alkoxycarbonyl group; and R3 and R4 may form a heterocyclic ring together with a nitrogen atom to which R3 and R4 are bound, through another heteroatom or without it; or an acid salt thereof, which is excellent in pharmacological effect and repressed in side effects as a drug for circulatory diseases.

The preparation of Some 4- and 5-Substituted Pyridine-2-carboxylic Acids as Fusaric Acid Analogues.

In view of future studies on the structure-activity relationships involved in the inhibition of dopamine β-hydroxylase, the authors synthetized 5-substituted picolinic acids and 4-substituted fusaric acids selected by means of a random sampling procedure suited for small series.On this occasion, they succeeded in improving markedly the well-known synthesis of 5-nitropicolinic acid via a Rosenmund-v.Braun reaction with 2-bromo-5-nitropyridine. 5-Hydroxypicolinic acid which is easily accessible in the same way could be converted into 5-alkyloxypicolinic acids by reaction with alkyl halides in DMSO in the presence of silver oxide. 4-Substituted fusaric acids became accessible via 5-n-butyl-2-methyl-4-nitropyridine-N-oxide.