24715-90-0

Basic information

• Product Name: 4-PYRROLIDINOBUTYLAMINE
• Synonyms: 4-PyrrolidinbutylaMine;(4-pyrrolidin-1-ylbutyl)amine;4-1-pyrrolidinylbutan-1-amine;4-pyrrolidin-1-ylbutylamine;4-Pyrrolidin-1-yl-butylamine;1-Pyrrolidinebutanamine;TIMTEC-BB SBB010289;RARECHEM AL BW 0242
• CAS NO: 24715-90-0
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;pyrrole
• Mol File: 24715-90-0.mol

Chemical Properties

• Boiling Point: 97°C 15mm
• Flash Point: 79.4 °C
• Appearance: /
• Density: 0.923 g/cm³
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.48±0.20(Predicted)
• Water Solubility: Soluble in water
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-PYRROLIDINOBUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRROLIDINOBUTYLAMINE(24715-90-0)
• EPA Substance Registry System: 4-PYRROLIDINOBUTYLAMINE(24715-90-0)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 24715-90-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-PYRROLIDINOBUTYLAMINE is used as a reagent for the preparation of imidazolidinedione derivatives, which are known for their antimalarial properties. These derivatives are effective against various strains of Plasmodium, the parasite responsible for malaria, making 4-PYRROLIDINOBUTYLAMINE a valuable asset in the development of new antimalarial drugs.
Used in Organic Synthesis:
4-PYRROLIDINOBUTYLAMINE is also used as a building block in organic synthesis, allowing chemists to create a wide range of complex molecules with diverse applications. Its unique structure and reactivity make it a versatile component in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.

Synthesis Reference(s)

Journal of the American Chemical Society, 95, p. 3038, 1973 DOI: 10.1021/ja00790a064

InChI:InChI=1/C8H18N2/c9-5-1-2-6-10-7-3-4-8-10/h1-9H2

Upstream product

• 110-63-4 Butane-1,4-diol 
• 109-99-9 tetrahydrofuran 
• 7664-41-7 ammonia 
• 123-75-1 pyrrolidine 

Downstream Products

• 101872-91-7 3,4,5-trimethoxy-benzoic acid-(4-pyrrolidino-butylamide) 
• 102314-72-7 3,4,5-trimethoxy-trans-cinnamic acid-(4-pyrrolidino-butylamide) 
• 110045-54-0 N-(4-Chloro-phenyl)-N'-[4-(4-pyrrolidin-1-yl-butylamino)-6-trichloromethyl-[1,3,5]triazin-2-yl]-guanidine 
• 144154-98-3 7-Chloro-10-hydroxy-1-[(E)-4-pyrrolidin-1-yl-butylimino]-3-(3-trifluoromethyl-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 64058-09-9 3-methyl-3-[4-(1-methyl-pyrrolidinium-1-yl)-butyl]-3-azonia-bicyclo[3.3.1]nonane; diiodide 
• 252003-32-0 3-(2,5-difluoro-4-methyl-benzyloxy)-5-[3-(4-pyrrolidin-1-yl butyl)-ureido]-isothiazole-4-carboxylic acid amide 
• 252003-65-9 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-isothiazolecarboxamide 
• 401817-09-2 N-{4-[2-(3-chlorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}-N-(4-pyrrolidin-1-ylbutyl)amine 
• 441295-44-9 4-[[[3-(1-pyrrolidinyl)propyl]amino]methyl]benzonitrile 
• 441295-48-3 4-[[[4-(1-pyrrolidinyl)butyl]amino]methyl]benzonitrile 
• 945104-09-6 1-(4-{[3-(4-tert-butylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl]methyl}pyridin-2-yl)-3-(4-pyrrolidin-1-ylbutyl)urea 
• 1197879-81-4 4-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-N-(4-pyrrolidin-1-yl-butyl)-benzamide 
• 505059-75-6 3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-N-[4-(pyrrolidin-1-yl)butyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamidine 

Relevant articles and documents

Steric effects in the catalytic amination of γ-, δ-, and ε-glycols

The amination of butane-1,4-diol, isomeric dipropylene glycols, and cyclohexane-1,4-diyldimethanol in the presence of nickel/copper/chromium catalysts has been studied. The effect of the initial glycol structure on the reaction selectivity has been estima

Activity of copper- and iron-containing catalysts in the reaction of diols with ammonia in the presence of hydrogen

An investigation has been made of the vapour-phase reaction of 1,4-butanediol, 1,5-pentadiol, 1,6-hexanediol and 2,5-hexanediol with ammonia and hydrogen at a temperature of 160-230°C on oxide copper-zinc-aluminium catalyst SNM-1 and a reduced, promoted, sintered iron catalyst. The composition of the main reaction products has been established, and schemes of their formation are suggested.