591-07-1

Basic information

• Product Name: ACETYLUREA
• Synonyms: N-Carbamoylacetamide;N-aminocarbonylethanamide;NSC 2766;ACETYLUREA;1-Acetylurea;Acetamide,N-(aminocarbonyl)-;Acetic acid, ureide;acetyl-ure
• CAS NO: 591-07-1
• Molecular Formula: C₃H₆N₂O₂
• Molecular Weight: 102.09
• EINECS: 209-698-3
• Mol File: 591-07-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 216-218°C
• Boiling Point: 191.38°C (rough estimate)
• Appearance: /
• Density: 1.204
• Refractive Index: 1.5110 (estimate)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Sparingly, Sonicated), Methanol (Slightly, Sonicated), Water (Slightly)
• PKA: 13.00±0.70(Predicted)
• Water Solubility: 13g/L(15 oC)
• BRN: 1751301
• CAS DataBase Reference: ACETYLUREA(CAS DataBase Reference)
• NIST Chemistry Reference: ACETYLUREA(591-07-1)
• EPA Substance Registry System: ACETYLUREA(591-07-1)

Safety Data

• Safety Statements: 22-24/25
• RTECS: AB4331500
• TSCA: Yes
• Hazardous Substances Data: 591-07-1(Hazardous Substances Data)

Usage

Uses

Acetylurea is used in the preparation Multiple urea derivative compounds which includes glycogen phosphorylase inhibitors

Synthesis Reference(s)

The Journal of Organic Chemistry, 15, p. 249, 1950 DOI: 10.1021/jo01148a006

InChI:InChI=1/C3H6N2O2/c1-2(6)5-3(4)7/h1H3,(H3,4,5,6,7)

Upstream product

• 2597-54-8 ethyl acetylcarbamate 
• 108-24-7 acetic anhydride 
• 57-13-6 urea 
• 75-36-5 acetyl chloride 
• 74-89-5 methylamine 
• 35629-70-0 2-amino-4-methyloxazole 
• 67337-69-3 methyl-5 hydantoine 
• 6270-46-8 5-amino-6-methyluracil 
• 7732-18-5 water 
• 85576-52-9 4-hydroperoxy-5-hydroxy-4-methyl-imidazolidin-2-one 
• 7722-84-1 dihydrogen peroxide 
• 591-08-2 acetylthiourea 
• 3998-25-2 acetyl isocyanate 
• 7664-41-7 ammonia 

Downstream Products

• 933-19-7 6-methyl-1,3,5-triazine-2,4(1H,3H)-dione 
• 301-02-0 cis-9-octadecenoamide 
• 58042-95-8 acide 5,5-diethyl-4-iminobarbiturique 
• 117514-34-8 N-acetyl-N'-(2,5-dimethyl-phenyl)-urea 
• 86902-94-5 1,5-Bis-carbamimidoyl-biuret 
• 598-49-2 N-chloroacetamide 
• 60-35-5 acetamide 
• 108-80-5 isocyanuric acid 
• 638-20-0 N,N'-diacetylurea 
• 98953-33-4 acetyl-(4-amino-2-hydroxy-benzoyl)-amine 
• 51443-74-4 N-Acetyl-N'-diethylaminomethyl-diethylester 
• 873972-81-7 N-acetyl-N'-butyryl-urea 
• 857476-58-5 N-acetyl-N'-(2-hydroxy-3,5-dimethyl-benzyl)-urea 
• 124-40-3 dimethyl amine 

Relevant articles and documents

Preparation method of 4-halobutyl acetate

The invention discloses a preparation method of 4-halobutyl acetate, relates to the preparation method of acetate and aims to solve the technical problems that in an existing method for preparing the4-halobutyl acetate, the reaction time is long, the reaction temperature is high, the cost is high, a toxic reagent is used, the operation is complicated, and the yield is low. The preparation methodcomprises the following steps: mixing and stirring urea, tetrahydrofuran and acetyl halide, naturally cooling to room temperature, adding distilled water, regulating pH (Potential of Hydrogen) to be neutral, carrying out suction filtration, extracting, drying, filtering, and distilling. The 4-halobutyl acetate prepared by the invention structurally contains an ester group and chain end halogen andis a multi-purpose polyfunctional compound. The 4-halobutyl acetate prepared by the invention is prepared from corresponding acyl halide and cyclic ether under catalysis of the urea, and the preparation method is bran-new. A solid byproduct of the preparation method is acyl urea. The preparation method disclosed by the invention has the advantages of simple operation, low cost, safety and high efficiency, environment friendliness and the like.

Method for synthesis of high-concentration anhydrous peracetic acid solution and co-production of acetylurea

The invention discloses a method for synthesis of a high-concentration anhydrous peracetic acid solution and co-production of acetylurea. According to the method, peracetic acid and acetylurea are generated via a reaction between percarbamide and acetic anhydride under the action of a catalyst; and then the high-concentration anhydrous peracetic acid solution is separated out via vacuum distillation, the residual distillate is frozen, and the frozen residual distillate is recrystallized for preparation of acetylurea, wherein the catalyst is selected from boric acid, metaboric acid, sodium borate, sodium metaborate, sodium perborate or a corresponding hydrate. As the raw materials, percarbamide and acetic anhydride are cheap and easy to obtain; compared with a method for preparing the anhydrous peracetic acid solution via acetaldehyde oxidation, the method provided by the invention is simpler, less in equipment investment and safer; and by adoption of the method provided by the invention, both the anhydrous peracetic acid solution and acetylurea are prepared, so that the application range is broad and the added value is high.

Influence of N-donor bases and the solvent in oxodiperoxomolybdenum catalysed olefin epoxidation with hydrogen peroxide in ionic liquids

Biphasic catalytic olefin epoxidation systems consisting of oxodiperoxomolybdenum catalysts in 1-n-alkyl-3-methylimidazolium hexafluorophosphate ionic liquid (IL) media with aqueous hydrogen peroxide oxidant were optimised by tuning the molecular structure of the IL and employing N-heterocyclic donor base additives to inhibit hydrolysis and enhance the activity of the catalyst. The latter study was only made possible by the solubilising properties of the IL media. Of the bases investigated, pyrazoles were identified as the most efficient additive species and the best results were obtained using 3,5-dimethylpyrazole. Immobilisation of the catalyst in the IL allowed for very efficient catalyst recycling. Finally, the compound [MoO(O 2)2(3-Mepz)2] (3-Mepz = 3-methylpyrazole) was characterised and its structure determined by X-ray crystallography.