26911-66-0 Usage
Uses
Used in Pharmaceutical Industry:
5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-ol is used as a potential active pharmaceutical ingredient for the development of new drugs. Its unique structure and potential pharmacological activity make it a candidate for the treatment of various diseases or conditions. 5,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDIN-2-OL's specific biological properties and mechanisms of action need to be further investigated to optimize its therapeutic potential.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-ol serves as a valuable compound for studying the structure-activity relationship of pyrazolopyrimidine derivatives. Researchers can use this compound to design and synthesize new analogs with improved pharmacological properties, potentially leading to the discovery of novel therapeutic agents.
Used in Drug Discovery and Development:
5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-ol is utilized in drug discovery and development processes to identify and optimize potential drug candidates. Its unique chemical structure and potential biological activities make it a useful starting point for the design of new drugs targeting specific diseases or conditions. Further research is necessary to evaluate its safety, efficacy, and pharmacokinetic properties in preclinical and clinical studies.
Used in Chemical Synthesis:
In the realm of chemical synthesis, 5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-ol can be employed as a key intermediate or building block for the synthesis of more complex molecules with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. Its unique structure and reactivity make it a valuable component in the development of novel compounds with diverse properties and functions.
Used in Biological Research:
5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-ol can be used in biological research to study its interactions with various biological targets, such as enzymes, receptors, or cellular pathways. This information can help researchers understand the compound's mechanism of action and its potential therapeutic effects, as well as identify potential side effects or toxicities. Such research can provide valuable insights into the development of new drugs and therapeutic strategies based on this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 26911-66-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,9,1 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 26911-66:
(7*2)+(6*6)+(5*9)+(4*1)+(3*1)+(2*6)+(1*6)=120
120 % 10 = 0
So 26911-66-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H9N3O/c1-5-3-6(2)11-7(9-5)4-8(12)10-11/h3-4H,1-2H3,(H,10,12)
26911-66-0Relevant articles and documents
Synthesis of N- and C-azolyl-substituted pyrazolo[1,5-a]pyrimidines by recyclization of pyrimidinium salts
Danagulyan, Gevorg G.,Tumanyan, Araksya K.,Attaryan, Oganes S.,Tamazyan, Rafael A.,Danagulyan, Anna G.,Ayvazyan, Armen G.
, p. 483 - 490 (2015/10/19)
We studied the reaction of 2-(ethoxycarbonyl)methyl-1,4,6-trimethylpyrimidinium iodide with hydrazides of N-azolyl- and C-pyrazolyl-substituted carboxylic acids, which were synthesized by reacting the respective esters with hydrazine hydrate. This reaction was shown to result in recyclization and formation of ethyl 2-(pyrazolylalkyl)- and 2-(azolylalkyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine- 3-carboxylates. Besides pyrazolopyrimidines, the separation of reaction mixture provided in some cases also another recyclization product, 2-hydroxy-5,7-dimethylpyrazolo[1,5-a]pyrimidine.
Novel route for the transformation of a pyrimidine ring using hydrazides
Danagulyan,Tadevosyan,Tamazyan,Panosyan
, p. 233 - 245 (2007/10/03)
It has been shown from X-ray structural analytical data that the reaction of 2-ethoxycarbonylmethyl-1,4,6-trimethylpyrimidinium iodide with carboxylic acid hydrazides gives pyrazolo[1,5-a]pyrimidine derivatives and not the isomeric triazolo[4,3-a]pyridines previously reported. This novel and previously unreported rearrangement of 1,2-dialkylpyrimidinium salts occurs via recyclization of the pyrimidine ring with inclusion of a fragment of the nucleophilic reagent into the transformation product. 2006 Springer Science+Business Media, Inc.
STUDIES IN THE FIELD OF NITROGEN HETEROCYCLIC COMPOUNDS. PART XIV. SYNTHESIS OF PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES
Balicki, Roman
, p. 1251 - 1261 (2007/10/02)
The reactions of various β-dicarbonyl compounds, β-diketones (1a-1g), β-ketoaldehydes (1h-1j) and β-ketoesters (1k-1w) with 3-amino-5-pyrazolone (2) in acetic acid solution were examined.On the basis of the experimental data obtained, a general scheme of this reaction was proposed.In the first, reversible step of the reaction, the intermediates (A, B, C) can be formed as a result of a competitive attack of three possible nucleophilic centers of 2 (C-4, N-1, -NH2) on a more positive carbonyl carbon atom of compound 1.Subsequent intermolecular cyclization of intermediates affords the corresponding pyrazolopyridines (3) and/or pyrazolopyrimidines (4, 6).It was found that the direction of cyclocondensation was noticeably affected by the nature of the dicarbonyl precursor, as well as the charge distribution and relative nucleophility of active centers of pyrazole ring within individual intermediates.