5,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDIN-2-OL

Base Information

• Chemical Name: 5,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDIN-2-OL
• CAS No.: 26911-66-0
• Molecular Formula: C8H9 N3 O
• Molecular Weight: 163.18
• Hs Code.: 2933990090
• Mol file: 26911-66-0.mol

Synonyms:Pyrazolo[1,5-a]pyrimidin-2-ol,5,7-dimethyl- (6CI,8CI); 5,7-Dimethyl-2-hydroxypyrazolo[1,5-a]pyrimidine;5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-ol; NSC 179797

Chemical Property of 5,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDIN-2-OL

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 50.42000
• Density: 1.35g/cm³
• LogP: 1.05170

Purity/Quality:

5,7-Dimethylpyrazolo[1,5-a]pyrimidin-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDIN-2-OL

There total 25 articles about 5,7-DIMETHYLPYRAZOLO[1,5-A]PYRIMIDIN-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

5-amino-1,2-dihydropyrazol-3-one (28491-52-3) + acetylacetone (123-54-6,81235-32-7) → 4,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo<3,4-b>pyridine (28491-67-0) + 2-oxo-5,7-dimethyl-1,2-dihydro-pyrazolo<1,5-a>pyrimidine (26911-66-0)

Guidance literature:

With acetic acid; for 2h; Heating;

Reference yield: 54.0%

C7H11BrN4O + 4,6-Dimethyl-2-pyrimidinylacetic acid ethyl ester iodomethylate → ethyl 2-[2-(4-bromo-3-methyl-1H-pyrazol-1-yl)ethyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate + ethyl 4,6-dimethyl-2-methylaminopyridine-3-carboxylate (69081-08-9) + 2-hydroxy-5,7-dimethylpyrazolo(1,5-a)-pyrimidine (26911-66-0) + 4,6-Dimethyl-2-pyrimidinylacetic acid ethyl ester (22114-32-5)

Guidance literature:

In ethanol; for 40h; Reflux; Sealed tube;

DOI:10.1007/s10593-015-1724-3

Reference yield: 50.0%

acetic acid hydrazide (1068-57-1) + 4,6-Dimethyl-2-pyrimidinylacetic acid ethyl ester iodomethylate → ethyl 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carboxylate (16108-48-8) + 2-hydroxy-5,7-dimethylpyrazolo(1,5-a)-pyrimidine (26911-66-0) + 4,6-Dimethyl-2-pyrimidinylacetic acid ethyl ester (22114-32-5)

Guidance literature:

In water; at 100 ℃; for 40h;

DOI:10.1007/s10593-006-0077-3

upstream raw materials:

5-amino-1,2-dihydropyrazol-3-one

acetylacetone

4-(cyanoacetyl-hydrazono)-pentan-2-one

Cyanoacetohydrazide

Downstream raw materials:

4,6-dimethyl-3-oxo-2,3-dihydro-1H-pyrazolo<3,4-b>pyridine

(3-(2-Benzyloxy-5-methyl-pyrazolo(1,5-a)pyrimidin-7-yl)-propylidene)bisphosphonic acid tetraethyl ester