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2-Bromo-4-hydroxybenzoic acid, a derivative of benzoic acid, is a chemical compound characterized by the molecular formula C7H5BrO3. It features a bromine atom and a hydroxyl group on the benzene ring, giving it unique chemical properties. This white crystalline solid, with a melting point of 223-226 °C, is slightly soluble in water and must be handled with care due to its potential hazards.

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  • 28547-28-6 Structure
  • Basic information

    1. Product Name: 2-Bromo-4-hydroxybenzoicacid
    2. Synonyms: 2-Bromo-4-hydroxybenzoicacid
    3. CAS NO:28547-28-6
    4. Molecular Formula: C7H5BrO3
    5. Molecular Weight: 217.0168
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 28547-28-6.mol
  • Chemical Properties

    1. Melting Point: 151 °C
    2. Boiling Point: 366.3±32.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.861±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Inert atmosphere,Room Temperature
    8. Solubility: N/A
    9. PKA: 3.22±0.10(Predicted)
    10. CAS DataBase Reference: 2-Bromo-4-hydroxybenzoicacid(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-Bromo-4-hydroxybenzoicacid(28547-28-6)
    12. EPA Substance Registry System: 2-Bromo-4-hydroxybenzoicacid(28547-28-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 28547-28-6(Hazardous Substances Data)

28547-28-6 Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4-hydroxybenzoic acid is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows it to be a key component in the development of new medications, contributing to the advancement of pharmaceutical research and drug discovery.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 2-Bromo-4-hydroxybenzoic acid serves as an intermediate in the production of dyes and pigments. Its chemical properties make it suitable for creating a wide range of colorants used in various applications, including textiles, plastics, and printing inks.
Used in Organic Synthesis:
2-Bromo-4-hydroxybenzoic acid is also utilized as a building block in the synthesis of organic compounds. Its versatile structure enables chemists to create a variety of organic molecules for different purposes, such as in the development of new materials, catalysts, and other specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 28547-28-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,5,4 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 28547-28:
(7*2)+(6*8)+(5*5)+(4*4)+(3*7)+(2*2)+(1*8)=136
136 % 10 = 6
So 28547-28-6 is a valid CAS Registry Number.

28547-28-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-4-hydroxybenzoic acid

1.2 Other means of identification

Product number -
Other names Benzoic acid, 2-bromo-4-hydroxy-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28547-28-6 SDS

28547-28-6Relevant articles and documents

Imidazole-containing condensed tricyclic compound and application thereof

-

Paragraph 0481, (2018/03/01)

The invention discloses an imidazole-containing condensed tricyclic compound adopting the structure as shown in the formula (I) or pharmaceutically acceptable salts, stereisomers or prodrug molecules thereof. The imidazole-containing condensed tricyclic compound has the IDO1 activity regulation function, can enhance T-cell activation through blocking immune checkpoints IDO1, is used for treating IDO1-mediated immunosuppression, and therefore, can become an effective medicine for treating malignant tumors. When used together with checkpoint protein anti-body drugs or other anti-cancer drugs, the imidazole-containing condensed tricyclic compound can enhance the anti-cancer effect. Meanwhile, the imidazole-containing condensed tricyclic compound has the potential of effectively treating IDO1 abnormity related immunosuppressive diseases and has a high application value.

Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors

Moreno-Sanz, Guillermo,Duranti, Andrea,Melzig, Laurin,Fiorelli, Claudio,Ruda, Gian Filippo,Colombano, Giampiero,Mestichelli, Paola,Sanchini, Silvano,Tontini, Andrea,Mor, Marco,Bandiera, Tiziano,Scarpelli, Rita,Tarzia, Giorgio,Piomelli, Daniele

, p. 5917 - 5930 (2013/08/23)

The peripherally restricted fatty acid amide hydrolase (FAAH) inhibitor URB937 (3, cyclohexylcarbamic acid 3′-carbamoyl-6-hydroxybiphenyl-3-yl ester) is extruded from the brain and spinal cord by the Abcg2 efflux transporter. Despite its inability to enter the central nervous system (CNS), 3 exerts profound antinociceptive effects in mice and rats, which result from the inhibition of FAAH in peripheral tissues and the consequent enhancement of anandamide signaling at CB1 cannabinoid receptors localized on sensory nerve endings. In the present study, we examined the structure-activity relationships (SAR) for the biphenyl region of compound 3, focusing on the carbamoyl and hydroxyl groups in the distal and proximal phenyl rings. Our SAR studies generated a new series of peripherally restricted FAAH inhibitors and identified compound 35 (cyclohexylcarbamic acid 3′-carbamoyl-5- hydroxybiphenyl-3-yl ester) as the most potent brain-impermeant FAAH inhibitor disclosed to date.

The direct conversion of light into continuous mechanical energy by photoreversible self-assembly: A prototype of a light-powered engine

Masiero, Stefano,Lena, Stefano,Pieraccini, Silvia,Spada, Gian Piero

supporting information; experimental part, p. 3184 - 3187 (2009/02/08)

En route to a clean engine: The concentration of a chemical system containing an azobenzene derivative can be varied cyclically by light, and this variation has been exploited to produce continuous work. The cyclic concentration change of the system is th

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