Welcome to LookChem.com Sign In|Join Free

CAS

  • or

290835-85-7

2,6-Dichloro-3-fluoroacetophenone is an aryl fluorinated building block, a halogenated derivative of Acetophenone (A164015), characterized by its clear colorless to light yellow liquid appearance. It serves as a reagent in the production of fragrances and resin polymers, and is also utilized in the synthesis of enantiomerically pure forms of specific compounds.

290835-85-7 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 290835-85-7 Structure

  • Basic information

    1. Product Name: 2,6-Dichloro-3-fluoroacetophenone
    2. Synonyms: 2,6-DICHLORO-5-FLUORO ACETOPHENONE;2',6'-DICHLORO-3'-FLUOROACETOPHENONE;2,6-DICHLORO-3-FLUOROACETOPHENONE;1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHANONE;2',6'-Dichloro-3'-Fluoroacetophenone 3-Fluoro-2,6-Dichloroacetophenone;2,6-dichloro-3-fluro acetophenone;2',6'-DICHLORO-3'-FLUOROACETOPHENONE, 98;2',6'-Dichloro-3'-fluoroacetophenone 98%
    3. CAS NO:290835-85-7
    4. Molecular Formula: C8H5Cl2FO
    5. Molecular Weight: 207.03
    6. EINECS: N/A
    7. Product Categories: Carbonyl Compounds;C7 to C8;Carbonyl Compounds;Ketones
    8. Mol File: 290835-85-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 255 °C(lit.)
    3. Flash Point: 255°C
    4. Appearance: Clear colorless to light yellow/Liquid
    5. Density: 1.403 g/mL at 25 °C(lit.)
    6. Vapor Pressure: 0.143mmHg at 25°C
    7. Refractive Index: n20/D 1.529(lit.)
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: 2,6-Dichloro-3-fluoroacetophenone(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,6-Dichloro-3-fluoroacetophenone(290835-85-7)
    12. EPA Substance Registry System: 2,6-Dichloro-3-fluoroacetophenone(290835-85-7)

  • Safety Data

    1. Hazard Codes: Xi,F,T
    2. Statements: 36/37/38-22-25
    3. Safety Statements: 37/39-26-45
    4. RIDADR: UN 2810 6.1/PG 3
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: IRRITANT
    8. PackingGroup: III
    9. Hazardous Substances Data: 290835-85-7(Hazardous Substances Data)

290835-85-7 Usage

Uses

Used in Fragrance and Resin Polymer Production:
2,6-Dichloro-3-fluoroacetophenone is used as a reagent for the production of fragrances and resin polymers, due to its ability to enhance the properties and characteristics of these products.
Used in Synthesis of Enantiomerically Pure Compounds:
In the chemical industry, 2,6-Dichloro-3-fluoroacetophenone is used as a key intermediate in the synthesis of the enantiomerically pure form of (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol, which is important for the development of various pharmaceuticals and specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 290835-85-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,0,8,3 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 290835-85:
(8*2)+(7*9)+(6*0)+(5*8)+(4*3)+(3*5)+(2*8)+(1*5)=167
167 % 10 = 7
So 290835-85-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H5Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-3H,1H3

290835-85-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Alfa Aesar

  • (H26638)  2',6'-Dichloro-3'-fluoroacetophenone, 98%   

  • 290835-85-7

  • 5g

  • 629.0CNY

  • Detail

  • Alfa Aesar

  • (H26638)  2',6'-Dichloro-3'-fluoroacetophenone, 98%   

  • 290835-85-7

  • 25g

  • 1930.0CNY

  • Detail

290835-85-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2,6-dichloro-3-fluorophenyl)ethanone

1.2 Other means of identification

Product number -
Other names 2',6'-Dichloro-3'-fluoroacetophenone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:290835-85-7 SDS

290835-85-7Synthetic route

1-(2,6-dichloro-3-fluorophenyl)ethanol
756520-66-8

1-(2,6-dichloro-3-fluorophenyl)ethanol

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

Conditions
ConditionsYield
With chloroamine-T; zinc dibromide In acetonitrile for 5h; Reflux;93%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

acetyl chloride
75-36-5

acetyl chloride

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane; nitrobenzene at 20℃; for 3h;50.7%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol
330156-50-8

(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol

Conditions
ConditionsYield
With RuBr2[(R,R)-2,4-bis-(di-3,5-xylylphosphino)pentane]-(6-(p-tolyl)-2-pyridyl)methanamine; potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 7600.51 Torr; for 21h; Reagent/catalyst; Autoclave; Inert atmosphere;100%
With methanol; sodium tetrahydroborate; (S)-diphenylprolinol at 5 - 20℃; for 5h; stereoselective reaction;98.3%
With sodium tetrahydroborate; chloro-trimethyl-silane; (S)-diphenylprolinol In tetrahydrofuran at 25 - 70℃; for 1h;95%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

1-(2,6-dichloro-3-fluorophenyl)ethanol
756520-66-8

1-(2,6-dichloro-3-fluorophenyl)ethanol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0 - 20℃; for 0.666667h;100%
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;
Stage #2: With hydrogenchloride In methanol; water at 0℃; pH=6;		98%
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;
Stage #2: With hydrogenchloride In methanol; water at 0℃; pH=6;		98%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol
877397-65-4

(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

Conditions
ConditionsYield
With RuBr2[(S,S)-2,4-bis(diphenylphosphino)pentane](2-aminomethyl-3,5-dimethylpyridine); potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; for 21h; Reagent/catalyst; Concentration; Autoclave; Inert atmosphere;100%
With RuBr2[(S,S)-2,4-bis-(di-3,5-xylylphosphino)pentane]-2-picolylamine; potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 7600.51 Torr; for 21h; Catalytic behavior; Reagent/catalyst; Pressure; Concentration; Time; Autoclave; Inert atmosphere;100%
With potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 7600.51 Torr; for 21h; Reagent/catalyst; Autoclave; Inert atmosphere;100%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

A

(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol
877397-65-4

(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

B

(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol
330156-50-8

(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol

Conditions
ConditionsYield
With RuBr2[(S,S)-2,4-bis(diphenylphosphino)pentane](2-picolylamine); potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; for 21h; Autoclave; Inert atmosphere;A 100%
B n/a
With C33H29FeMnN2O3P(1+)*Br(1-); potassium tert-butylate; hydrogen In ethanol at 50℃; under 37503.8 Torr; for 16h; Autoclave; Overall yield = 92 %; enantioselective reaction;A n/a
B n/a
With C41H46FeMnN3O5P(1+)*Br(1-); hydrogen; potassium carbonate In ethanol at 50℃; under 37503.8 Torr; for 16h; Overall yield = 90 percent; enantioselective reaction;A n/a
B n/a
With hydrogen; C42H36FeMnN3O3P(1+)*Br(1-); potassium hydroxide In methanol at 20℃; under 22502.3 Torr; for 10h; Inert atmosphere; Glovebox; Autoclave; Overall yield = 88 percent; Overall yield = 182.2 mg; enantioselective reaction;A n/a
B n/a
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

α,α,α,2,6-pentachloro-3-fluoroacetophenone
1341170-75-9

α,α,α,2,6-pentachloro-3-fluoroacetophenone

Conditions
ConditionsYield
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With chlorine In acetic acid at 60℃; for 5h;
Stage #2: With sodium acetate In acetic acid at 60 - 100℃;		98%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

2,6‑dichloro‑3‑fluorobenzoic acid

2,6‑dichloro‑3‑fluorobenzoic acid

Conditions
ConditionsYield
With sodium hypochlorite at 50℃; Temperature;84%
With water; bromine; sodium hydroxide In 1,4-dioxane at -5 - 20℃; for 3h;
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With sodium hypobromide In 1,4-dioxane; water at 0 - 20℃; for 3h;
Stage #2: With hydrogenchloride In 1,4-dioxane; water
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With bromine; sodium hydroxide In 1,4-dioxane; water at -5 - 20℃;
Stage #2: With hydrogenchloride In 1,4-dioxane; water
With water; bromine; sodium hydroxide In 1,4-dioxane at 0 - 20℃;
amidinothiocarbamide
2114-02-5

amidinothiocarbamide

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

N-(4-(2,6-dichloro-3-fluorophenyl)-1,3-thiazol-2-yl)guanidine

N-(4-(2,6-dichloro-3-fluorophenyl)-1,3-thiazol-2-yl)guanidine

Conditions
ConditionsYield
With Oxone; sodium bromide In methanol at 60℃; for 2h;71%
2-amino-5-chlorobenzyl alcohol
37585-25-4

2-amino-5-chlorobenzyl alcohol

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

2-(2,6-dichloro-3-fluorophenyl)quinoline

2-(2,6-dichloro-3-fluorophenyl)quinoline

Conditions
ConditionsYield
With sodium hydroxide In toluene at 135℃; for 24h; Green chemistry;61%
4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde
114393-97-4

4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C24H20Cl2FNO2
1207094-14-1

C24H20Cl2FNO2

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃;
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C25H21Cl2FN4O
1207094-29-8

C25H21Cl2FN4O

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / methanol / 20 °C
2: sodium hydroxide / methanol
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(2,6-dichloro-5-fluorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one
1304143-30-3

1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(2,6-dichloro-5-fluorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / methanol / 20 °C
2: sodium hydroxide / methanol
3: acetic acid / Reflux
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

methyl 2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoate

methyl 2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid
877399-13-8

2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation
6.1: lithium hydroxide / methanol; water / 0.75 h / 60 °C / Inert atmosphere
6.2: pH 5 / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C19H17Cl2FN4O3

C19H17Cl2FN4O3

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C18H15Cl2FN4O3

C18H15Cl2FN4O3

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation
6.1: lithium hydroxide / methanol; water / 60 °C / Inert atmosphere
6.2: pH 5 / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

tert-butyl 4-((4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)methyl)-4-hydroxypiperidine-1-carboxylate

tert-butyl 4-((4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)methyl)-4-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

tert-butyl 3-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
877399-36-5

tert-butyl 3-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C25H28Cl2FN5O3

C25H28Cl2FN5O3

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C25H28Cl2FN5O3

C25H28Cl2FN5O3

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
6.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere
7.1: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 12 h / 40 °C / Inert atmosphere
8.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 87 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C26H30Cl2FN5O3

C26H30Cl2FN5O3

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
6.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere
7.1: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 12 h / 40 °C / Inert atmosphere
8.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 87 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
756521-08-1

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
756520-67-9

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3: acetic acid; iron / ethanol / 1.25 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3: iron; acetic acid / ethanol / 1 h / Reflux
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(±)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine
756503-69-2

(±)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3: acetic acid; iron / ethanol / 1.25 h / Reflux
4: N-Bromosuccinimide / acetonitrile; dichloromethane / 0.17 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3: iron; acetic acid / ethanol / 1 h / Reflux
4: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
756520-48-6

5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1H-pyrazol-1-yl)pyridin-2-amine

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1H-pyrazol-1-yl)pyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: copper(l) iodide; potassium phosphate; dodecane / dimethyl sulfoxide / 2 h / 150 °C / Inert atmosphere; Microwave irradiation
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

N-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-pyridin-3-yl)benzamide
877620-62-7

N-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-pyridin-3-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: copper(l) iodide; potassium phosphate; dodecane / dimethyl sulfoxide / 2 h / 150 °C / Inert atmosphere; Microwave irradiation
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-nicotinonitrile
756508-98-2

6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-nicotinonitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / water; N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-phenylpyridin-2-amine

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-phenylpyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere
View Scheme

290835-85-7Relevant articles and documents

Method for preparing aldehyde or ketone by oxidizing reaction alcohol oxide

-

Paragraph 0043-0046, (2021/11/03)

The invention relates to a method for preparing aldehyde or ketone by oxidizing reaction alcohol oxide. The invention belongs to the field of medicine and chemical engineering, and particularly relates to a nitric acid and organic nitrogen oxide composition as a catalyst. The invention is prepared by the oxidation reaction of alcohol, wherein the oxidant is oxygen, and the nitric acid and organic nitrogen oxide composition are used as a catalytic system. The reaction is homogeneous reaction, and the catalytic system is simplified. The method is simple and convenient to operate, high in yield and low in cost. The invention is a very economical and simple method for preparing aldehyde or ketone from alcohol, and is suitable for industrial production.

Method for efficiently synthesizing 2,6-dichloro-3-fluoroacetophenone

-

Paragraph 0014-0018, (2020/11/23)

The invention relates to a method for efficiently synthesizing 2,6-dichloro-3-fluoroacetophenone, belonging to the field of pharmacy. The method for efficiently synthesizing 2,6-dichloro-3-fluoroacetophenone in the invention comprises the following steps: with 2,4-dichlorofluorobenzene and acetyl chloride as raw materials, carrying out an acylation reaction in a mixed solvent under the action of chloride, conducting sufficient reacting, and then performing separating and purifying to obtain the high-purity target product. The method is simple in synthetic process route, convenient in post-treatment and suitable for large-scale industrial production.

Zinc(II)-catalyzed oxidation of alcohols to carbonyl compounds with chloramine-T

Wang, Peng,Cai, Jin,Yang, Jiabin,Sun, Chunlong,Li, Lushen,Hu, Huayou,Ji, Min

supporting information, p. 533 - 535 (2013/02/25)

Efficient oxidation of primary and secondary alcohols to the corresponding carbonyl compounds can be carried out in acetonitrile, using chloramine-T in the presence of catalytic zinc(II) salts. Primary alcohols are selectively oxidized to aldehydes without carboxylic acid byproduct.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 290835-85-7