29201-96-5Relevant articles and documents
Practical Synthesis of Polymethylated Flavones: Nobiletin and Its Desmethyl Derivatives
Asakawa, Tomohiro,Sagara, Hiroto,Kanakogi, Masaki,Hiza, Aiki,Tsukaguchi, Yuta,Ogawa, Takahiro,Nakayama, Miho,Ouchi, Hitoshi,Inai, Makoto,Kan, Toshiyuki
, p. 595 - 602 (2019/04/01)
We present a practical synthesis of the polymethoxylated citrus flavone nobiletin that is suitable for use on a hundred gram scale. Ready availability of this compound and its derivatives will aid detailed chemical-biological investigations of their biological activities, including activation of signaling via the cAMP-dependent protein kinase A/extracellular signal-related protein kinase/cAMP response element-binding protein pathway.
Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations
Sagara, Hiroto,Kanakogi, Masaki,Tara, Yuki,Ouchi, Hitoshi,Kimura, Junko,Kaneko, Yukiko,Inai, Makoto,Asakawa, Tomohiro,Ishikawa, Tomohisa,Kan, Toshiyuki
, p. 1816 - 1818 (2018/04/11)
We accomplished a divergent synthesis of sudachitin (2), a polymethoxyflavone isolated from citrus fruits, and six derivatives from acetophenone 9, which was an intermediate in our previous synthesis of nobiletin (1). Compound 2 enhanced glucose-induced i
Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production
Oshitari, Tetsuta,Okuyama, Yuji,Miyata, Yoshiki,Kosano, Hiroshi,Takahashi, Hideyo,Natsugari, Hideaki
, p. 4540 - 4544 (2011/09/12)
A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially available methyl 3,4,5-trimethoxybenzoate as a starting material for concise preparation of the key intermediate, 2′-hydro