32937-55-6Relevant articles and documents
An Improved Process for the Enantioselective Synthesis of HCV NS5A Inhibitor Elbasvir (MK-8742) Chiral Amine Intermediate
Chapala, Vijaya Lakshmi,Katari, Naresh Kumar,Kerru, Nagaraju,Malavattu, Giri Prasad,Marisetti, Vishnu Murthy,Reddy, Pedavenkatagari Narayana
, p. 932 - 938 (2021/06/26)
Abstract: Large-scale enantioselective synthesis of the chiral amine unit of HCV NS5A inhibitor Elbasvir has been accomplished in six steps, with 55% overall yield. The process includes a highly enantioselective reduction of the NH imine using R-(+)-diphe
Organic boron luminescent material, preparation method thereof and application
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Paragraph 0037-0041, (2019/05/22)
The invention discloses an organic boron luminescent material, and belongs to the technical field of organic optoelectronic materials. The organic boron luminescent material is structurally characterized in that two organic boron units are introduced onto phenyl quinoline, B on one organic boron unit and N on adjacent quinoline can form intramolecular coordination, so that the organic boron unit has four-coordination boron properties, and the other organic boron unit has three-coordination boron properties at the adjacent position and meta-position or para-position of the quinoline, so that aPi conjugate organic boron luminescent compound is formed. The organic boron luminescent material can emit strong yellow light in a solid state. A preparation method of the organic boron luminescent material is simple in synthetic step, the prepared organic boron luminescent material can be used for luminescent materials and electron transport materials, a triaryl boron unit in the material and fluorine ions can act, and p-pi conjugation between the B and an adjacent conjugate unit is interrupted, so that the luminescent material can be used for detection of the fluorine ions.
Facile synthesis of 1-naphthols through a copper-catalyzed arylation of methyl ketones with o-bromoacetophenones
Lou, Zhen-Bang,Pang, Xin-Long,Chen, Chao,Wen, Li-Rong,Li, Ming
supporting information, p. 1231 - 1235 (2015/12/30)
The coupling reactions of simple methyl ketones with o-bromoacetophenones and subsquential cyclization reactions were realized to produce a range of 1-naphthols. These cascade reactions were initiated by a rare Cu-catalyzed arylation reaction of methyl ketones with aromatic bromides.
Base-catalyzed synthesis of substituted indazoles under mild, transition-metal-free conditions
Thome, Isabelle,Besson, Claire,Kleine, Tillmann,Bolm, Carsten
, p. 7509 - 7513 (2013/07/26)
Back to basics: A transition-metal-free method developed for the synthesis of indazoles involves an inexpensive catalytic system composed of a diamine and K2CO3. Various (Z)-2-bromoacetophenone tosylhydrazones were converted into indazoles at room temperature in excellent yields (see example; Ts=p-toluenesulfonyl). The yield was improved by photoisomerization with UV light when E/Z isomeric mixtures of the starting material were used. Copyright
Synthesis and characterization of chiral benzylic ether-bridged periodic mesoporous organosilicas
Morell, Juergen,Chatterjee, Sangam,Klar, Peter J.,Mauder, Daniel,Shenderovich, Ilja,Hoffmann, Frank,Froeba, Michael
scheme or table, p. 5935 - 5940 (2009/05/31)
The first synthesis of a chiral periodic mesoporous organosilica (PMO) carrying benzylic ether bridging groups is reported. By hydrolysis and condensation of the new designed chiral organosilica precursor 1,4-bis(triethoxysilyl)-2-(1 -methoxyethyl)benzene