349397-71-3

Basic information

• Product Name: N-(4-bromo-2-methylphenyl)benzamide
• Synonyms: N-(4-bromo-2-methylphenyl)benzamide
• CAS NO: 349397-71-3
• Molecular Formula: C14H12BrNO
• Molecular Weight: 290.15518
• Mol File: 349397-71-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-bromo-2-methylphenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromo-2-methylphenyl)benzamide(349397-71-3)
• EPA Substance Registry System: N-(4-bromo-2-methylphenyl)benzamide(349397-71-3)

Safety Data

• Hazardous Substances Data: 349397-71-3(Hazardous Substances Data)

Upstream product

• 584-70-3 N-benzoyl-2-methylaniline 
• 10035-10-6 hydrogen bromide 
• 7722-84-1 dihydrogen peroxide 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 93-58-3 benzoic acid methyl ester 
• 583-75-5 4-Bromo-2-methylaniline 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

A practical and sustainable protocol for direct amidation of unactivated esters under transition-metal-free and solvent-free conditions

In this paper, a NaOtBu-mediated synthesis approach was developed for direct amidation of unactivated esters with amines under transition-metal-free and solvent-free conditions, affording a series of amides in good to excellent yields at room temperature. In particular, an environmentally friendly and practical workup procedure, which circumvents the use of organic solvents and chromatography in most cases, was disclosed. Moreover, the gram-scale production of representative products3a,3wand3auwas efficiently realized by applying operationally simple, sustainable and practical procedures. Furthermore, this approach was also applicable to the synthesis of valuable molecules such as moclobemide (a powerful antidepressant), benodanil and fenfuram (two commercial agricultural fungicides). These results demonstrate that this protocol has the potential to streamline amide synthesis in industry. Meanwhile, quantitative green metrics of all the target products were evaluated, implying that the present protocol is advantageous over the reported ones in terms of environmental friendliness and sustainability. Finally, additional experiments and computational calculations were carried out to elucidate the mechanistic insight of this transformation, and one plausible mechanism was provided on the basis of these results and the related literature reports.

CYCLOPROPANEAMINE COMPOUND

The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group or heterocyclic group optionally having substituent(s); R is H, a hydrocarbon group or heterocyclic group optionally having substituent(s); A and R are optionally bonded to each other to form a ring optionally having substituent(s); Q1, Q2, Q3 and Q4 are each a hydrogen atom or a substituent; Q1 and Q2, and Q3 and Q4, are each optionally bonded to each other to form a ring optionally having substituent(s); X is H, an acyclic hydrocarbon group or saturated cyclic group optionally having substituent(s); Y1, Y2 and Y3 are each H, a hydrocarbon group or heterocyclic group optionally having substituent(s); X and Y1, and Y1 and Y2, are each optionally bonded to each other to form a ring optionally having substituent(s); and Z1, Z2 and Z3 are each H or a substituent, or a salt thereof.

Copper-catalyzed selective benzylic C-O cyclization of N-o-tolylbenzamides: Synthesis of 4 H-3,1-benzoxazines

A novel Selectfluor-mediated copper-catalyzed highly selective benzylic C-O cyclization for the synthesis 4H-3,1-benzoxazines is reported. The predominant selectivity for a benzylic C(sp3)-H over an aromatic C(sp 2)-H bond in N-o-tolylbenzamides is achieved.