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Methyl-7-azaindole-4-carboxylate is a chemical compound characterized by the presence of a methyl group, a 7-azaindole ring, and a carboxylate functional group. It is recognized for its potential biological activity and is frequently utilized in the synthesis of pharmaceuticals and agrochemicals. This versatile compound is also prominent in medicinal chemistry research and has been investigated for its potential in the development of innovative drugs and crop protection products, attracting considerable attention in the scientific community due to its possible therapeutic properties.

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  • 351439-07-1 Structure
  • Basic information

    1. Product Name: MEHYL-7-AZAINDOLE-4-CARBOXYLATE
    2. Synonyms: MEHYL-7-AZAINDOLE-4-CARBOXYLATE;METHYL1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLATE;1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, methyl ester;Methyl 7-azaindole-4-carboxylate;Methyl 7-azaindole-4-carb...;7-Azaindole-4-carboxylic acid Methyl ester ;7-azaindole-4-carboxlic acid methyl ester
    3. CAS NO:351439-07-1
    4. Molecular Formula: C9H8N2O2
    5. Molecular Weight: 176.18
    6. EINECS: N/A
    7. Product Categories: Heterocycle-Pyridine series
    8. Mol File: 351439-07-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.324 g/cm3
    6. Refractive Index: 1.648
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 12.68±0.40(Predicted)
    10. CAS DataBase Reference: MEHYL-7-AZAINDOLE-4-CARBOXYLATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: MEHYL-7-AZAINDOLE-4-CARBOXYLATE(351439-07-1)
    12. EPA Substance Registry System: MEHYL-7-AZAINDOLE-4-CARBOXYLATE(351439-07-1)
  • Safety Data

    1. Hazard Codes: Xi,T
    2. Statements: 25
    3. Safety Statements: 45
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 351439-07-1(Hazardous Substances Data)

351439-07-1 Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl-7-azaindole-4-carboxylate is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique molecular structure allows it to be a key component in the development of new medications, contributing to the advancement of healthcare solutions.
Used in Agrochemical Production:
In the agrochemical industry, Methyl-7-azaindole-4-carboxylate is employed as an intermediate in the production of crop protection products. Its incorporation aids in the creation of effective agents that protect crops from pests and diseases, thereby ensuring agricultural productivity and food security.
Used in Medicinal Chemistry Research:
Methyl-7-azaindole-4-carboxylate is utilized as a research compound in medicinal chemistry. Its potential biological activity makes it a valuable tool for studying and understanding various biological processes and mechanisms, which can lead to the discovery of new therapeutic agents and treatments.
Used in Drug Development:
Mehyl-7-Azaindole-4-Carboxylate is also used in the development of new drugs. Its versatile nature and potential therapeutic properties make it a promising candidate for the creation of novel pharmaceuticals that address unmet medical needs and improve patient outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 351439-07-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,1,4,3 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 351439-07:
(8*3)+(7*5)+(6*1)+(5*4)+(4*3)+(3*9)+(2*0)+(1*7)=131
131 % 10 = 1
So 351439-07-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2O2/c1-13-9(12)7-3-5-11-8-6(7)2-4-10-8/h2-5H,1H3,(H,10,11)

351439-07-1 Well-known Company Product Price

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  • Aldrich

  • (ADE000950)  Methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate  AldrichCPR

  • 351439-07-1

  • ADE000950-1G

  • 7,411.95CNY

  • Detail

351439-07-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate

1.2 Other means of identification

Product number -
Other names methyl 1H-pyrrolo[2,3-b]pyridine-4-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:351439-07-1 SDS

351439-07-1Relevant articles and documents

Palladium-catalysed functionalisation at 4- and 6- position of the 7-azaindole system

Allegretti, Marcello,Arcadi, Antonio,Marinelli, Fabio,Nicolini, Luca

, p. 609 - 612 (2001)

The synthesis of 4- and 6-substituted-7 azaindales through palladium-catalysed coupling reactions of the corresponding halosubstituted-7-azaindoles is described.

Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies

Bala, Sandeepchowdary,Yellamanda, Kalisha vali,Kadari, Anilkumar,Ravinuthala, Venkata.S.U.,Kattula, Bhavita,Singh, Om V.,Gundla, Rambabu,Addlagatta, Anthony

, (2021/08/03)

Methionine aminopeptidases (MetAPs) are an important class of enzymes that work co-translationally for the removal of initiator methionine. Chemical inhibition or gene knockdown is lethal to the microbes suggesting that they can be used as antibiotic targ

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

Bengtsson, Christoffer,Blaho, Stefan,Saitton, David Blomberg,Brickmann, Kay,Broddefalk, Johan,Davidsson, ?jvind,Drmota, Tomas,Folmer, Rutger,Hallberg, Kenth,Hallén, Stefan,Hovland, Ragnar,Isin, Emre,Johannesson, Petra,Kull, Bengt,Larsson, Lars-Olof,L?fgren, Lars,Nilsson, Kristina E.,Noeske, Tobias,Oakes, Nick,Plowright, Alleyn T.,Schnecke, Volker,Sthlberg, Pernilla,S?rme, Pernilla,Wan, Hong,Wellner, Eric,?ster, Linda

supporting information; experimental part, p. 3039 - 3053 (2011/06/27)

Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Optimization led to compounds 33 and 37, which exhibit potent inhibition of human ACC2, 10-fold selectivity over inhibition of human ACC1, good physical and in vitro ADME properties and good bioavailability. X-ray crystallography has shown this series binding in the CT-domain of ACC2 and revealed two key hydrogen bonding interactions. Both 33 and 37 lower levels of hepatic malonyl-CoA in vivo in obese Zucker rats.

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