351439-07-1

Basic information

• Product Name: MEHYL-7-AZAINDOLE-4-CARBOXYLATE
• Synonyms: MEHYL-7-AZAINDOLE-4-CARBOXYLATE;METHYL1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLATE;1H-Pyrrolo[2,3-b]pyridine-4-carboxylic acid, methyl ester;Methyl 7-azaindole-4-carboxylate;Methyl 7-azaindole-4-carb...;7-Azaindole-4-carboxylic acid Methyl ester ;7-azaindole-4-carboxlic acid methyl ester
• CAS NO: 351439-07-1
• Molecular Formula: C9H8N2O2
• Molecular Weight: 176.18
• Product Categories: Heterocycle-Pyridine series
• Mol File: 351439-07-1.mol

Chemical Properties

• Appearance: /
• Density: 1.324 g/cm³
• Refractive Index: 1.648
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.68±0.40(Predicted)
• CAS DataBase Reference: MEHYL-7-AZAINDOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: MEHYL-7-AZAINDOLE-4-CARBOXYLATE(351439-07-1)
• EPA Substance Registry System: MEHYL-7-AZAINDOLE-4-CARBOXYLATE(351439-07-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 351439-07-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl-7-azaindole-4-carboxylate is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique molecular structure allows it to be a key component in the development of new medications, contributing to the advancement of healthcare solutions.
Used in Agrochemical Production:
In the agrochemical industry, Methyl-7-azaindole-4-carboxylate is employed as an intermediate in the production of crop protection products. Its incorporation aids in the creation of effective agents that protect crops from pests and diseases, thereby ensuring agricultural productivity and food security.
Used in Medicinal Chemistry Research:
Methyl-7-azaindole-4-carboxylate is utilized as a research compound in medicinal chemistry. Its potential biological activity makes it a valuable tool for studying and understanding various biological processes and mechanisms, which can lead to the discovery of new therapeutic agents and treatments.
Used in Drug Development:
Mehyl-7-Azaindole-4-Carboxylate is also used in the development of new drugs. Its versatile nature and potential therapeutic properties make it a promising candidate for the creation of novel pharmaceuticals that address unmet medical needs and improve patient outcomes.

InChI:InChI=1/C9H8N2O2/c1-13-9(12)7-3-5-11-8-6(7)2-4-10-8/h2-5H,1H3,(H,10,11)

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 443729-67-7 4-Iodo-1-acetyl-7-azaindole 
• 479553-01-0 1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 344327-11-3 1H-pyrrolo[2,3-b]pyridine-4-carbonitrile 
• 348640-06-2 4-bromo-7-azaindole 

Downstream Products

• 1190312-37-8 methyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylate 
• 1261744-93-7 methyl 6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylate 
• 1261476-04-3 6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 
• 1312812-82-0 tert-butyl [(trans-4-((6-phenyl-1H-pyrrolo[2,3-b]pyridine-4-carboxamido)methyl)cyclohexyl)methyl]carbamate 
• 1167056-92-9 6-chloro-1H-pyrrolo[2,3-b]pyridine-4-carboxylic acid 
• 1190314-06-7 methyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-4-carboxylate 

Relevant articles and documents

Palladium-catalysed functionalisation at 4- and 6- position of the 7-azaindole system

The synthesis of 4- and 6-substituted-7 azaindales through palladium-catalysed coupling reactions of the corresponding halosubstituted-7-azaindoles is described.

Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies

Methionine aminopeptidases (MetAPs) are an important class of enzymes that work co-translationally for the removal of initiator methionine. Chemical inhibition or gene knockdown is lethal to the microbes suggesting that they can be used as antibiotic targ

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats

Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Optimization led to compounds 33 and 37, which exhibit potent inhibition of human ACC2, 10-fold selectivity over inhibition of human ACC1, good physical and in vitro ADME properties and good bioavailability. X-ray crystallography has shown this series binding in the CT-domain of ACC2 and revealed two key hydrogen bonding interactions. Both 33 and 37 lower levels of hepatic malonyl-CoA in vivo in obese Zucker rats.