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1-tert-butyl-4-methyl-4-cyanopiperidine-1,4-dicarboxylate, also known as Boc-4-Cyano-L-Proline a-methyl ester, is a chemical compound belonging to the piperidine class of organic compounds. It is a derivative of piperidine, featuring a tert-butyl and a methyl group attached to the piperidine ring, along with a cyano group and two carboxylate groups. These structural features endow it with unique properties, making it a valuable building block in the synthesis of pharmaceutical and medicinal products.

362703-34-2

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362703-34-2 Usage

Uses

Used in Pharmaceutical Synthesis:
1-tert-butyl-4-methyl-4-cyanopiperidine-1,4-dicarboxylate is used as a building block for the synthesis of various pharmaceutical and medicinal products. Its unique structure allows for the creation of diverse drug candidates with potential therapeutic applications.
Used in Drug Development Research:
In the field of drug development, 1-tert-butyl-4-methyl-4-cyanopiperidine-1,4-dicarboxylate serves as a key intermediate in the synthesis of novel compounds with potential biological activities. Its presence in the molecular structure can influence the pharmacokinetics, pharmacodynamics, and overall efficacy of the resulting drugs.
Used in Medicinal Chemistry:
1-tert-butyl-4-methyl-4-cyanopiperidine-1,4-dicarboxylate is utilized in medicinal chemistry for the design and optimization of drug molecules. Its functional groups can be modified or used to attach other chemical moieties, enabling the development of compounds with improved potency, selectivity, and safety profiles.
Used in Organic Synthesis:
Beyond its applications in the pharmaceutical industry, 1-tert-butyl-4-methyl-4-cyanopiperidine-1,4-dicarboxylate can also be employed in organic synthesis for the preparation of other organic compounds with various applications in different industries, such as materials science, agrochemicals, and specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 362703-34-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,2,7,0 and 3 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 362703-34:
(8*3)+(7*6)+(6*2)+(5*7)+(4*0)+(3*3)+(2*3)+(1*4)=132
132 % 10 = 2
So 362703-34-2 is a valid CAS Registry Number.

362703-34-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-O-tert-butyl 4-O-methyl 4-cyanopiperidine-1,4-dicarboxylate

1.2 Other means of identification

Product number -
Other names 1-tert-Butyl 4-methyl 4-cyanopiperidine-1,4-dicarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:362703-34-2 SDS

362703-34-2Relevant articles and documents

LIM KINASE INHIBITORS

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, (2015/11/02)

The present invention relates to new kinase inhibitors, more specifically LIM Kinase inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and Prophylaxis of disease. In particular, the present invention relates to new LIMK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and Prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said Compounds in the manufacture of a medicament for the application to a number of therapeutic indications including Ophthalmic and intestinal diseases.

Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers

Woo, Hyun Min,Lee, Yun Suk,Roh, Eun Joo,Seo, Seon Hee,Song, Chi Man,Chung, Hye Jin,Pae, Ae Nim,Shin, Kye Jung

, p. 5910 - 5915 (2011/10/09)

To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 4-piperidinecarboxylate and 4-piperidinecyanide derivatives were prepared and evaluated for in vitro and in vivo activity against α1G calcium channel. Among them, several compounds showed good T-type calcium channel inhibitory activity and minimal off-target activity over hERG channel (% inhibition at 10 μM = 61.85-71.99, hERG channel IC50 = 1.57 ± 0.14-4.98 ± 0.36 μM). Selected compound 31a was evaluated on SNL model of neuropathic pain and showed inhibitory effect on mechanical allodynia.

Synthesis and structure-activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors

Gilmore, John L.,King, Bryan W.,Harris, Cathy,Maduskuie, Thomas,Mercer, Stephen E.,Liu, Rui-Qin,Covington, Maryanne B.,Qian, Mingxin,Ribadeneria, Maria D.,Vaddi, Krishna,Trzaskos, James M.,Newton, Robert C.,Decicco, Carl P.,Duan, James J.-W.

, p. 2699 - 2704 (2007/10/03)

A novel series of achiral TNF-α converting enzyme (TACE) inhibitors has been discovered. These compounds exhibited activities from 0.35 to 11 nM in a porcine TACE assay and inhibited TNF-α production in an LPS-stimulated whole blood assay with an IC5

Beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha

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Page/Page column 46, (2010/11/30)

The present application describes novel β-amino acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, Ua, Xa, Ya, Za, R1, R2, R3

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