372122-55-9Relevant articles and documents
The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors
Cheung, Mui,Harris, Philip A.,Badiang, Jennifer G.,Peckham, Gregory E.,Chamberlain, Stanley D.,Alberti, Michael J.,Jung, David K.,Harris, Stephanie S.,Bramson, Neal H.,Epperly, Andrea H.,Stimpson, Stephen A.,Peel, Michael R.
scheme or table, p. 5428 - 5430 (2009/06/18)
A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.
SUBSTITUTED PYRAZOLO [1,5-α] PYRIDINE COMPOUNDS AND THEIR METHODS OF USE
-
Page/Page column 55, (2010/11/29)
The present invention is directed to substituted pyrazolo[l,5-α]pyridines and related methods for their synthesis and use.
Pyrazolo[1,5-a]pyridines as p38 kinase inhibitors
Stevens, Kirk L.,Jung, David K.,Alberti, Michael J.,Badiang, Jennifer G.,Peckham, Gregory E.,Veal, Jim M.,Cheung, Mui,Harris, Philip A.,Chamberlain, Stanley D.,Peel, Michael R.
, p. 4753 - 4756 (2007/10/03)
(Chemical Equation Presented) A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with alkynes or by thermal cyclization of disubstituted azirines. Subseque
Fused pyrazole derivatives bieng protein kinase inhibitors
-
, (2008/06/13)
Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, (R2, and R4 are various substituent groups, are protein kinase inhibitors.
PROCESS FOR THE PREPARATION OF CHEMICAL COMPOUNDS
-
Page/Page column 5-6, (2008/06/13)
The invention provides a process for preparing a compound of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from H. halogen, C1-6alkyl, C1-6alkoxy.