372122-55-9

Basic information

• Product Name: 2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIDINE
• Synonyms: 2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIDINE
• CAS NO: 372122-55-9
• Molecular Formula: C₁₄H₈F₄N₂
• Molecular Weight: 280.22
• Mol File: 372122-55-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIDINE(372122-55-9)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)-6-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIDINE(372122-55-9)

Safety Data

• Hazardous Substances Data: 372122-55-9(Hazardous Substances Data)

Usage

Chemical Family

Pyrazolo[1,5-a]pyridine

Fluorophenyl group presence

Yes

Trifluoromethyl group presence

Yes

Potential use in industries

Pharmaceutical and agrochemical

Possible biological activity

Inflammation and pain management

Unique feature

Scaffold and functional groups

Research and development potential

High, for therapeutic applications

Upstream product

• 1085712-45-3 C₁₆H₁₀F₄N₂O₂ 
• 372122-66-2 1-(4-fluorophenyl)-2-(2-(5-trifluoromethyl)pyridyl)ethanone oxime 
• 401816-45-3 3-(4-fluorophenyl)-2-(2-(5-trifluoromethyl)pyridyl)-2H-azirine 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 145834-67-9 1-(4-fluorophenyl)-2-[5-(trifluoromethyl)-2-pyridyl]ethanone 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 

Downstream Products

• 401816-46-4 2-(4-fluorophenyl)-3-acetyl-6-trifluoromethylpyrazolo[1,5-a]pyridine 
• 468062-76-2 2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine-3-carbaldehyde 
• 267235-95-0 2-(4-fluorophenyl)-3-bromo-6-trifluoromethylpyrazolo[1,5-a]pyridine 
• 401816-55-5 4-[2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-(4-methoxybenzyloxy)propyl)-2-pyrimidinamine 
• 401816-63-5 3-{4-[2-(4-fluoro-phenyl)-6-triethoxymethyl-pyrazolo[1,5-a]pyridin-3-yl]-pyrimidin-2-ylamino}-propan-1-ol 
• 401816-64-6 2-(4-fluoro-phenyl)-3-[2-(3-hydroxy-propylamino)-pyrimidin-4-yl]-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester 
• 401816-50-0 N-Cyclopropyl-4-[2-(4-fluorophenyl)-6-trifluoromethylpyrazolo[1,5-a]pyridin-3-yl]-2-pyrimidinamine 
• 401816-47-5 2-(4-fluorophenyl)-3-(3-(dimethylamino)-2-propenoyl)-6-trifluoromethylpyrazolo[1,5-a]pyridine 
• 474304-05-7 N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-6-(triethoxymethyl)pyrazolo[1,5-a]pyridin-7-amine 
• 474303-58-7 7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester 

Relevant articles and documents

The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors

A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.

SUBSTITUTED PYRAZOLO [1,5-α] PYRIDINE COMPOUNDS AND THEIR METHODS OF USE

The present invention is directed to substituted pyrazolo[l,5-α]pyridines and related methods for their synthesis and use.

Pyrazolo[1,5-a]pyridines as p38 kinase inhibitors

(Chemical Equation Presented) A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with alkynes or by thermal cyclization of disubstituted azirines. Subseque

Fused pyrazole derivatives bieng protein kinase inhibitors

Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, (R2, and R4 are various substituent groups, are protein kinase inhibitors.

PROCESS FOR THE PREPARATION OF CHEMICAL COMPOUNDS

The invention provides a process for preparing a compound of formula (I) and pharmaceutically acceptable derivatives thereof wherein: R0 and R1 are independently selected from H. halogen, C1-6alkyl, C1-6alkoxy.