437-81-0

Basic information

• Product Name: 2,6-Difluorobenzaldehyde
• Synonyms: 2,6-DIFLUOROBENZALDEHYDE;TIMTEC-BB SBB006685;2,6-Difluorobenzaldehyde,97%;3,4,5-triflurobenzenenitrile;2,6-Difluorobenzaldehyde 98%;2,6-Difluorobenzaldehyde98%;2,6-DIFLUORLOBENZALDEHYDE;2-6-Difluorbenzaldehyd
• CAS NO: 437-81-0
• Molecular Formula: C₇H₄F₂O
• Molecular Weight: 142.1028664
• EINECS: -0
• Product Categories: Fluorobenzene;Carbonyl Compounds;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;API intermediates;Miscellaneous;Aldehydes;C7;Carbonyl Compounds;Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series
• Mol File: 437-81-0.mol

Chemical Properties

• Melting Point: 15-17 °C(lit.)
• Boiling Point: 82-84 °C15 mm Hg(lit.)
• Flash Point: 164 °F
• Appearance: Clear light yellow to bright yellow/Liquid
• Density: 1.317 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.46mmHg at 25°C
• Refractive Index: n20/D 1.502(lit.)
• Storage Temp.: 2-8°C
• Sensitive: Air Sensitive
• BRN: 1935273
• CAS DataBase Reference: 2,6-Difluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorobenzaldehyde(437-81-0)
• EPA Substance Registry System: 2,6-Difluorobenzaldehyde(437-81-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39-36/37
• WGK Germany: 2
• F: 10-23
• HazardClass: IRRITANT
• Hazardous Substances Data: 437-81-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Difluorobenzaldehyde is used as a reactant for the synthesis of 5-Cyano-6-(2,6-difluorophenyl)-5,6-dihydro-2-thiouracil, a compound with potential pharmaceutical applications. This synthesis is achieved through a one-pot cyclocondensation reaction with ethyl cyanoacetate and thiourea.
Used in Organic Synthesis:
In the field of organic synthesis, 2,6-Difluorobenzaldehyde serves as a reactant for the preparation of 1-(2,6-Difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazole. 2,6-Difluorobenzaldehyde is synthesized by reacting 2,6-difluorobenzaldehyde with 1,2-phenylenediamine in the presence of a catalytic amount of p-toluenesulfonic acid.
Used in the Synthesis of (3E)-4-(2,6-Difluorophenyl)-3-buten-2-one:
2,6-Difluorobenzaldehyde is also used in the Wittig olefination reaction to produce (3E)-4-(2,6-difluorophenyl)-3-buten-2-one. This reaction involves the use of acetylmethylidenetriphenyl phosphorane, resulting in the formation of a conjugated diene with potential applications in various chemical processes.
Used in the Preparation of Methyl 4-Fluorobenzo[b]thiophene-2-carboxylate:
Furthermore, 2,6-difluorobenzaldehyde is utilized in the synthesis of methyl 4-fluorobenzo[b]thiophene-2-carboxylate by treating it with methyl thioglycolate in the presence of K2CO3. This reaction leads to the formation of a heterocyclic compound with potential applications in various chemical and pharmaceutical industries.

InChI:InChI=1/C7H4F2O/c8-6-2-1-3-7(9)5(6)4-10/h1-4H

Upstream product

• 443-84-5 2,6-difluorotoluene 
• 372-18-9 1,3-Difluorobenzene 
• 93-61-8 N-methyl-N-phenylformamide 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 2751-90-8 tetraphenylphosphonium bromide 
• 85068-28-6 2,6-difluorophenylacetic acid 
• 67-56-1 methanol 
• 109-94-4 formic acid ethyl ester 
• 19064-18-7 2,6-difluorobenzyl alcohol 
• 207226-37-7 1,3-difluoro-2-vinyl-benzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 617-84-5 N-formyldiethylamine 

Downstream Products

• 120445-59-2 2,6-difluoro-benzaldehyde-semicarbazone 
• 385-00-2 2,6-difluorobenzoic acid 
• 1673-75-2 3-(2,6-difluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 129749-87-7 5-(2',6'-difluorobenzylidene)-3-methylbarbituric acid 
• 129749-87-7 5-(2',6'-difluorobenzylidene)-3-methylbarbituric acid 
• 82128-11-8 2-(2,6-difluorophenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 133214-28-5 meso-N,N'-Disalicylidene-1,2-bis(2,6-difluorophenyl)ethylenediamine 
• 146137-75-9 2-Benzylsulfanyl-6-fluoro-benzaldehyde 
• 133214-34-3 1,2-Bis-(2,6-difluoro-phenyl)-N,N'-bis-[1-(2,6-difluoro-phenyl)-meth-(E)-ylidene]-ethane-1,2-diamine 
• 91624-89-4 2-(difluoromethyl)-1,3-difluorobenzene 

Relevant articles and documents

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