- Latent Nucleophilic Carbenes
-
Using DFT and ab initio calculations, we demonstrate that noncyclic formamidines can undergo thermal rearrangement into their isomeric aminocarbenes under rather mild conditions. We synthesized the silylformamidine, for which the lowest activation energy in this process was predicted. Experimental studies proved it to serve as a very reactive nucleophilic carbene. The reactions with acetylenes, benzenes, and trifluoromethane proceeded via insertion into sp, sp2, and spCH bonds. The carbene also reacted with the functional groups, such as CHO, COR, and CN at double or triple bonds, displaying high mobility of the trimethylsilyl group. The obtained silylformamidine can be considered as a latent nucleophilic carbene. It can be prepared in bulk quantities, stored, and used when the need arises. Calculation results predict similar behavior for some other silylated formamidines and related compounds.
- Marchenko, Anatoliy,Koidan, Georgyi,Hurieva, Anastasiya,Shvydenko, Kostiantyn,Rozhenko, Alexander B.,Rusanov, Eduard B.,Kyrylchuk, Andrii A.,Kostyuk, Aleksandr
-
p. 373 - 385
(2021/12/27)
-
- Method for efficiently synthesizing fluorine-containing compound
-
The invention discloses a method for efficiently synthesizing a fluorine-containing compound, and relates to the field of fluorine-containing compound synthesis. The method is a method for generating a corresponding fluorine atom substituted fluorine-containing compound by reacting aromatic chloride or activated chloride serving as a raw material with potassium fluoride under the action of a novel catalyst. The method disclosed by the invention has the advantages of good product selectivity, high efficiency, mild reaction conditions, simplicity and convenience in operation, convenience in application and the like.
- -
-
Paragraph 0071-0073
(2021/06/26)
-
- A Magnetically Recyclable Palladium-Catalyzed Formylation of Aryl Iodides with Formic Acid as CO Source: A Practical Access to Aromatic Aldehydes
-
A magnetically recyclable palladium-catalyzed formylation of aryl iodides under CO gas-free conditions has been developed by using a bidentate phosphine ligand-modified magnetic nanoparticles-anchored- palladium(II) complex [2P-Fe 3O 4@SiO 2-Pd(OAc) 2] as catalyst, yielding a wide variety of aromatic aldehydes in moderate to excellent yields. Here, formic acid was employed as both the CO source and the hydrogen donor with iodine and PPh 3as the activators. This immobilized palladium catalyst can be obtained via a simple preparative procedure and can be facilely recovered simply by using an external magnetic field, and reused at least 9 times without any apparent loss of catalytic activity.
- You, Shengyong,Zhang, Rongli,Cai, Mingzhong
-
p. 1962 - 1970
(2021/01/25)
-
- Synthesis of 2, 6 - difluoro phenyl -1 - (4, 5 - [...]) -3 - ketone to make a new method
-
The invention discloses a method for synthesizing 2, 6 - difluoro phenyl - 1 - (4, 5 - [...]) - 3 - ethyl ketone of the new method. This synthetic route avoids the synthetic intermediate 1, 3 - difluoro - 2 - steps of styrene, overcome prior art intermediate volatile not easy to store, and due to the synthetic process needs to be used sodium hydride synthesis of operation and great danger of defect, so that the synthesis process is more suitable for large-scale production; the synthetic route higher yield, and the final target 2, 6 - difluoro phenyl - 1 - (4, 5 - [...]) - 3 - ethyl ketone through re-crystallization mode is purified, high purity 98%; and this synthetic route uses the raw materials of the commercial production of the raw material, cheap and easy to obtain.
- -
-
Paragraph 0040-0044
(2019/04/14)
-
- Pd-Catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups
-
The direct, Pd-catalyzed ortho C-H methylation and fluorination of benzaldehydes have been accomplished using commercially available orthanilic acids as transient directing groups. In these reactions, the 1-fluoro-2,4,6-trimethylpyridinium salts can be either a bystanding F+ oxidant or an electrophilic fluorinating reagent. An X-ray crystal structure of a benzaldehyde ortho C-H palladation intermediate was obtained using triphenylphosphine as the stabilizing ligand.
- Chen, Xiao-Yang,Sorensen, Erik J.
-
supporting information
p. 2789 - 2792
(2018/03/08)
-
- A 2, 6 - difluoro toluene of continuous oxidation to prepare 2, 6 - difluorobenzaldehyde method (by machine translation)
-
The invention relates to a 2, 6 - difluoro toluene of continuous oxidation to prepare 2, 6 - difluorobenzaldehyde method, which belongs to the technical field of organic synthesis process. The method is to 2, 6 - difluoro toluene compound as a raw materia
- -
-
Paragraph 0026; 0028; 0030; 0032; 0034; 0036; 0038; 0040
(2017/08/29)
-
- Barbier Continuous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Amidation
-
An ambient temperature continuous flow method for nucleophilic amidation and thioamidation is described. Deprotonation of formamides by lithium diisopropylamine (LDA) affords carbamoyllithium intermediates that are quenched in situ with various electrophi
- Ganiek, Maximilian A.,Becker, Matthias R.,Berionni, Guillaume,Zipse, Hendrik,Knochel, Paul
-
supporting information
p. 10280 - 10284
(2017/08/07)
-
- DIRECT DYES AND COMPOSITION COMPRISING THE DYES
-
The present invention relates to novel direct dyes and compositions comprising them for dyeing keratin fibers especially human hair. The novel dyes of the present invention have benzothiophene structure providing intensive and homogeneous dyeing on kerati
- -
-
Page/Page column 32
(2016/07/27)
-
- Polyoxometalate-Intercalated Layered Double Hydroxides as Efficient and Recyclable Bifunctional Catalysts for Cascade Reactions
-
The polyoxometalate (POM) intercalated layered double hydroxides (LDHs) have been widely used as heterogeneous catalysts. However, the application of POM-LDHs as bifunctional catalysts for cascade reaction has seldom been studied compared to the noble-metal-based catalysts. Herein, a series of POM-LDHs catalysts of Tris-LDH-X4(PW9)2 (X=Mn, Fe, Co, Ni, Cu, and Zn; Tris=Tris(hydroxymethtyl)aminomethane) have been prepared. The efficacy of Tris-LDH-Zn4(PW9)2 as efficient bifunctional catalyst has been demonstrated for cascade reactions involving oxidation of benzyl alcohol to benzaldehyde followed by Knoevenagel condensation with ethyl cyanoacetate to produce benzylidene ethyl cyanoacetate. The combination of POM's redox/acidic sites and LDHs's basic sites led to a composite catalyst with excellent activity (99 %) and selectivity (≥99 %) under mild and soluble-base-free conditions. This work offers a new design strategy for the fabrication of efficient bifunctional catalysts for the promotion of one-pot cascade reactions.
- Liu, Kai,Xu, Yanqi,Yao, Zhixiao,Miras, Haralampos N.,Song, Yu-Fei
-
p. 929 - 937
(2016/03/15)
-
- METHOD OF PRODUCING BENZENE COMPOUND
-
PROBLEM TO BE SOLVED: To provide a new production method for the benzene compound represented by formula (2). SOLUTION: The present invention provides a production method for the benzene compound represented by formula (2), the method including mixing of a compound represented by formula (1) and dimethyl sulfoxide (where R1, R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, an alkyl group, a fluorinated alkyl group, a hydroxyl group, an alkoxy group, an aryl group or a nitro group). COPYRIGHT: (C)2016,JPOandINPIT
- -
-
Paragraph 0072
(2016/12/01)
-
- Green and Efficient: Iron-Catalyzed Selective Oxidation of Olefins to Carbonyls with O2
-
A mild and operationally simple iron-catalyzed protocol for the selective aerobic oxidation of aromatic olefins to carbonyl compounds is described. Catalyzed by a Fe(III) species bearing a pyridine bisimidazoline ligand at 1 atm of O2, α- and β-substituted styrenes were cleaved to afford benzaldehydes and aromatic ketones generally in high yields with excellent chemoselectivity and very good functional group tolerance, including those containing radical-sensitive groups. With α-halo-substituted styrenes, the oxidation took place with concomitant halide migration to afford α-halo acetophenones. Various observations have been made, pointing to a mechanism in which both molecular oxygen and the olefinic substrate coordinate to the iron center, leading to the formation of a dioxetane intermediate, which collapses to give the carbonyl product. (Chemical Equation).
- Gonzalez-De-Castro, Angela,Xiao, Jianliang
-
supporting information
p. 8206 - 8218
(2015/07/15)
-
- Practical organic solvent-free Cu(OAc)2/DMAP/TEMPO-catalyzed aldehyde and imine formation from alcohols under air atmosphere
-
A highly efficient and practical organic solvent-free Cu(OAc)2/DMAP/TEMPO catalyst system for the selective aerobic oxidation of benzylic and allylic alcohols to aldehydes and phenones under an ambient air atmosphere was reported. A wide range of functional groups such as phenolic hydroxyl, amino, and methylthio are compatible with the catalyst system. The organic solvent-free aerobic oxidative imine synthesis from benzyl alcohol and amines was also achieved via the newly developed Cu(OAc)2/DMAP/TEMPO catalyst. 100 g-scale reactions for aldehyde and imine formation were achieved with over 90% yield using 0.5 mol% catalyst loading in 36 hours, presenting a potential valuable protocol for both economical and environmental considerations. This journal is
- Guan, Mingyu,Wang, Chao,Zhang, Jingyu,Zhao, Yingsheng
-
p. 48777 - 48782
(2014/12/10)
-
- TEMPO-mediated oxidation of primary alcohols to aldehydes under visible light and air
-
A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed using molecular oxygen from air as the terminal oxidant. Ru(bpy)3(PF 6)2 (bpy: bipyridyl) and Ir(dtb-bpy)(ppy) 2(PF6) (dtb-bpy: 4,4′-di-tert-butyl-2,2′- bipyridyl; ppy: 2-phenylpyridine) were used as the sensitizers. A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed. Molecular oxygen from air was the terminal oxidant. Copyright
- Liu, Dongwang,Zhou, Hongxia,Gu, Xiangyong,Shen, Xiaoqin,Li, Pixu
-
supporting information
p. 117 - 122
(2014/03/21)
-
- PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS
-
Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.
- -
-
Paragraph 0136; 0154-0155
(2015/01/07)
-
- Regioselective formylation of 1,3-disubstituted benzenes through in situ lithiation
-
A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.
- Wang, Le,Wang, Yan,Guo, Fangxu,Zheng, Yue,Bhadury, Pinaki S.,Sun, Zhihua
-
supporting information
p. 6053 - 6056
(2013/10/22)
-
- Facile preparation of aromatic esters from aromatic bromides with ethyl formate or DMF and molecular iodine via aryllithium
-
Various aromatic bromides were treated with n-BuLi and subsequently with ethyl formate, followed by the reaction with ethanol and molecular iodine in the presence of K2CO3 to provide the corresponding aromatic ethyl esters in good yields. Moreover, aromatic bromides could be transformed into the corresponding aromatic methyl esters in good yields by the treatment with n-BuLi and subsequently with DMF, followed by the reaction with methanol, molecular iodine, and K2CO3. Some aromatics could be also converted into the corresponding aromatic esters in good yields by the treatment with n-BuLi, and subsequently with ethyl formate or DMF, followed by the reaction with molecular iodine and K2CO3. The present reactions offer a novel route for the transition-metal-free, carbon-monoxide-free, and therefore environmentally benign one-pot conversion of aromatic bromides and aromatics into aromatic esters.
- Ushijima, Sousuke,Moriyama, Katsuhiko,Togo, Hideo
-
experimental part
p. 4701 - 4709
(2012/07/28)
-
- Biomimetic catalytic decarboxylation of phenylacetic acid derivatives by manganese(III) complex
-
Bis(2-hydroxyacetophenone)ethylendiimine as a quadridentate Schiff base ligand and its Mn(III) were synthesized and characterized by analytical and spectral data. An efficient homogeneous oxidative decarboxylation of some carboxylic acids was performed by catalytic amount of Mn(III) complex in chloroform, using tetrabutylamonium periodate as oxidant at room temperature.
- Montazerozohori,Nasr-Esfahani,Joohari,Akhlaghi,Dehghani
-
experimental part
p. 1081 - 1084
(2011/12/16)
-
- Efficient and selective oxidative decarboxylation of arylcarboxylic acids into the corresponding aldehydes and ketones using K5Co IIIW12O40 as a green oxidant under microwave and conventional heating
-
The oxidative decarboxylation of various α-aryl- and α, α-arylcarboxylic acids having electron-donating and electronwithdrawing groups by using a stoichiometric amount of potassium 12-tungstocobaltate(III), K5CoIIIW12O40, in 50% aqueous acetonitrile solution resulted in the corresponding aldehydes and ketones in high yields within short reaction times under microwave irradiation. This transformation was also carried out under the conventional heating conditions which produced the corresponding aldehydes and ketones in relatively longer reaction times. The arylacetic acids with electron-withdrawing substituents required longer reaction times and produced lower yields. In contrast to arylacetic esters which were inert toward decarboxylation, the sodium arylacetates were decarboxylated in shorter times with yields better than those of the parent acids.
- Farhadi,Ansari
-
experimental part
p. 470 - 476
(2012/06/18)
-
- Room-temperature nucleophilic aromatic fluorination: Experimental and theoretical studies
-
(Chemical Equation Presented) Taming the reagent: The use of anhydrous tetrabutylammonium fluoride (TBAFanh) in nucleophilic aromatic substitution reactions, including variants of the selective halogen-exchange and fluorodenitration processes (see scheme), was investigated. It was shown that TBAFanh permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media.
- Sun, Haoran,DiMagno, Stephen G.
-
p. 2720 - 2725
(2007/10/03)
-
- 4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na +/H+ exchanger isoform-1 (NHE-1) inhibitors
-
A series of 4-substituted (benzo[b]thiophene-2-carbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardioprotective efficacy both in vitro and in vivo. Several analogs exhibited a strong inhibition on NHE-1, and which was generally well correlated with their cardioprotective efficacy. Especially the 4-nitro 20 and cyano 50 compounds excellently improved the cardiac function and reduced infarct size against ischemia/reperfusion injury.
- Lee, Sunkyung,Lee, Hyunsuk,Kyu, Yang Yi,Byung, Ho Lee,Yoo, Sung-Eun,Lee, Kyunghee,Nam, Sook Cho
-
p. 2998 - 3001
(2007/10/03)
-
- Halex reactions of aromatic compounds catalysed by 2-azaallenium, carbophosphazenium, aminophosphonium and diphosphazenium salts: A comparative study
-
An increasing number of biologically active compounds in the pharma and agro-chemical sector contain carbon fluorine bonds. One of the most common methods to introduce fluorine into intermediates is the well-investigated halogen-exchange reaction, in which chloro- and bromoaromatics activated towards nucleophilic substitution, react with a fluoride source to yield the corresponding fluoroarenes. In general, the reaction is supported by phase-transfer catalysts. The use of a new class of very active phase-transfer catalysts gives the possibility of substituting even halogens with weak activation giving a convenient access to interesting compounds that are not available so far and opening up new synthetic routes in Halex chemistry. Our new classes of catalysts, CNC+ (1a), PNC+ (2a) and several different approaches presented by other groups are described and experimental results discussed.
- Pleschke, Axel,Marhold,Schneider,Kolomeitsev,R?schenthaler
-
p. 1031 - 1038
(2007/10/03)
-
- PHOSPHAZENIUM SALT MIXTURES CONTAINING HEXAKIS(AMINO)DIPHOSPHAZENIUM, TETRAKIS(AMINO)-PHOSPHONIUM AND POLYAMINOPHOSPAZENIUM SALTS
-
The invention relates to mixtures containing 5 99.5 wt. % of a compound of formula (I), 95 0.5 wt. % of a compound of formula (II) and a maximum of 10 wt. % of one of several compounds of general formula (III a), wherein A - A which are independent from each other are equal or different and represent a straight-chained or branched alkyl or alkenyl having 1 - 12 carbon atoms, cycloalkyl having 4 8 carbon atoms, an aryl having 6 -12 carbon atoms, an aralkyl having 7 - 12 carbon atoms, or A-A, A-A, A-A etc. - A-A which are independent from each other and are equal or different and are connected together directly or via O or N-A to a ring having 3 - 7 ring members, A represents an alkyl having 1 - 4 carbon atoms. X1 and/or X2 and/or X3 which are independent from each other represent a radical of formula (III b), or the radical X1 and/or X2 and/or X3 as well as a straight-chained or branched alkyl or alkenyl having 1 - 12 carbon atoms, cycloalkyl having 4 - 8 carbon atoms represent an aryl having 6 - 12 carbon atoms, an aralkyl having 7 - 12 carbon atoms, or respectively the radicals which are disposed on an identically bound nitrogen atom, e.g. A and A, A and A, A and A etc. - A and A which are independent from each other are equal or different and are connected together directly or via O or N-A to a ring having 3 - 7 ring members and A represents an alkyl having 1 - 4 carbon atoms and B represents a single-valent organic or inorganic acid radical or the equivalent of a multi-valent acid radical. The mixtures can be used as catalysts and co-catalysts for phase transfer reactions, nucleophilic substitution reactions or halogen-fluoro-exchange reactions.
- -
-
Page/Page column 12-13
(2010/02/08)
-
- SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease
-
SAR on the phenethylamide 1 (Ki 1.2μM) in the P2- and the P′-position led to potent inhibitors, one of which showed good exposure and low clearance when administered intramuscularly to rat.
- Malancona, Savina,Colarusso, Stefania,Ontoria, Jesus M.,Marchetti, Antonella,Poma, Marco,Stansfield, Ian,Laufer, Ralph,Di Marco, Annalise,Taliani, Marina,Verdirame, Maria,Gonzalez-Paz, Odalys,Matassa, Victor G.,Narjes, Frank
-
p. 4575 - 4579
(2007/10/03)
-
- METHOD FOR PRODUCING A COMPOUND CONTAINING FLUORINE VIA FLUORINE-HALOGEN EXCHANGE BY SPECIAL POLYAMINO PHOSPHAZENE CATALYSTS
-
The invention relates to a method for producing compounds containing fluorine by reacting a compound, which contains hydrogen that can be exchanged for fluorine, with a fluoride or with a mixture of fluorides of general formula (I): MeF, wherein Me represents an alkaline earth metal ion, an NH4+ ion or an alkali metal ion, in the presence or absence of a solvent at a temperature ranging from 60 to 260 °C. The invention is characterized in that the reaction is carried out in the presence of a compound or of a mixture of compounds of general formula (IIa) and/or (IIb), whereby X1 and/or X2 and/or X3, independent of one another, have groups of formula (llc) or other groups cited in the claims.
- -
-
-
- (Oxime)carbamoyl fatty acid amide hydrolase inhibitors
-
The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical compositions are useful for the treatment of conditions which can be effected by inhibiting fatty acid amide hydrolase including, but not limited to, neuropathic pain, emesis, anxiety, altering feeding behaviors, movement disorders, glaucoma, brain injury, and cardiovascular disease.
- -
-
-
- Aminophosphonium compounds
-
The present invention relates to compounds of the formula in which one, two or three of the radicals R1, R2, R3and R4are where m and n are an integer from 1 to 10, R5, R6, R7and R8are, independently of one another, identical or different and are a straight-chain or branched alkyl radical having 1 to 10 carbon atoms, and the remaining radical(s) R1to R4are or —NR9R10, where R9and R10are identical or different and are a straight-chain or branched alkyl radical having 1 to 10 carbon atoms, and X?is an inorganic or organic anion or an equivalent of a multiply charged inorganic or organic anion. The invention further relates to mixtures of substances comprising compounds of the formula (1), to a process for preparing the compounds of the formula (1) and to the use thereof.
- -
-
-
- Catalyst comprising an amidophosphonium salt for halex reactions
-
Catalyst for halogen-fluorine exchange reactions on aromatics, consisting essentially of a mixture of one or more compounds of the component a) plus at least one compound of the components b), c) and/or d), wherein a) is an amidophosphonium salt of the formula (I) STR1 where A1, A2, A3, A4, A5, A6, A7, A8 are, independently of one another, identical or different and are each a straight-chain or branched alkyl or alkenyl having from 1 to 12 carbon atoms, cycloalkyl having from 4 to 8 carbon atoms, an aryl having from 6 to 12 carbon atoms, an aralkyl having from 7 to 12 carbon atoms, or A1 A2, A3 A4, A5 A6, A7 A8 are, independently of one another, identical or different and are in each case connected to one another either directly or via O or N--A9 to form a ring having from 3 to 7 ring atoms, A9 is an alkyl having from 1 to 4 carbon atoms and B? is a monovalent acid anion or the equivalent of a polyvalent acid anion, b) a quaternary ammonium salt, c) a quaternary phosphonium salt, and d) a crown ether or a polyether of the formula (IV):
- -
-
-
- Process for preparing fluorinated benzyl alcohols and fluorinated benzaldehydes
-
Fluorinated benzaldehydes are obtainable in a simple and inexpensive manner and in significantly improved yields when chlorinated benzaldehydes are reacted with alkali metal fluorides at temperatures in the range from about 130 to 200 DEG C. in the presen
- -
-
-
- Isoquinoline compound melanocortin receptor ligands and methods of using same
-
The invention relates to melanocortin receptor ligands and methods of using the ligands to alter or regulate the activity of a melanocortin receptor. The invention further relates to tetrahydroisoquinoline aromatic amines that function as melanocortin receptor ligands and as agents for controlling cytokine-regulated physiologic processes and pathologies, and combinatorial libraries thereof.
- -
-
-
- 'HALEX' FLUORINATION OF CHLORINATED BENZALDEHYDES AND BENZOYL CHLORIDES
-
Spray-dried potassium fluoride, suspended in sulpholane at 220 degC, converted 2,4- and 2,6-dichlorobenzaldehyde into the corresponding difluoroaldehydes (yields ca. 65percent).Small amounts of the mono-substituted products (2-chloro-4-fluoro- + 4-chloro-2-fluorobenzaldehyde, and 2-chloro-6-fluoro-benzaldehyde, respectively) were also produced.Similar treatment of the 3,4-dichloro-analogue gave 3-chloro-4-fluorobenzaldehyde (yield 98percent, conversion 68percent), but 2- and 4-chlorobenzaldehyde gave very poor yields (ca. 5percent) of the 2- and 4-fluoro-derivatives. 2-Fluoro-, 4-fluoro- and 3-chloro-4-fluorobenzoyl fluoride were obtained (yields 60-65percent) by heating the corresponding chlorobenzoyl chlorides with potassium fluoride in sulpholane.
- Banks, R. Eric,Mothersdale, Kevin N.,Tipping, Anthony E.,Tsiliopoulos, Efthimios,Cozens, Barry J.,et al.
-
p. 529 - 537
(2007/10/02)
-
- Process for producing fluorobenzaldehydes
-
A process for producing a fluorobenzaldehyde of the formula: STR1 wherein X is a chlorine atom, a bromine atom or an iodine atom, n is an integer of from 1 to 5, and m is an integer of from 1 to 5, provided n≥m, which comprises reacting a halogenated benzaldehyde of the formula: STR2 wherein X and n are as defined above, with a metal fluoride in the presence of a catalyst, wherein at least one member selected from the group consisting of quaternary phosphonium salts and quaternary ammonium salts is used as the catalyst.
- -
-
-
- A Convenient Synthesis of Fluorobenzaldehydes by KF/Ph4PBr/18-Crown-6 Reagent System
-
4-Fluorobenzaldehyde was easily synthesized from 4-chlorobenzaldehyde by potassium fluoride in the presence of tetraphenylphosphonium halide plus 18-crown-6 or poly(ethylene glycol) dimethyl ether.Several fluorobenzaldehyde derivatives were similarly prepared from the corresponding chloro-derivatives in good yields.
- Yoshida, Yasuo,Kimura, Yoshikazu
-
p. 1355 - 1358
(2007/10/02)
-
- Hypoglycemic 5-substituted oxazolidine-2,4-diones
-
Hypoglycemic 5-phenyl and 5-naphthyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.
- -
-
-
