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CAS

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471905-61-0

2-(1-(4-chlorophenylsulfonyl)vinyl)-1,4-difluorobenzene is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 471905-61-0 Structure

  • Basic information

    1. Product Name: 2-(1-(4-chlorophenylsulfonyl)vinyl)-1,4-difluorobenzene
    2. Synonyms: 2-(1-(4-chlorophenylsulfonyl)vinyl)-1,4-difluorobenzene
    3. CAS NO:471905-61-0
    4. Molecular Formula: C14H9ClF2O2S
    5. Molecular Weight: 314.7348664
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 471905-61-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(1-(4-chlorophenylsulfonyl)vinyl)-1,4-difluorobenzene(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(1-(4-chlorophenylsulfonyl)vinyl)-1,4-difluorobenzene(471905-61-0)
    11. EPA Substance Registry System: 2-(1-(4-chlorophenylsulfonyl)vinyl)-1,4-difluorobenzene(471905-61-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 471905-61-0(Hazardous Substances Data)

471905-61-0 Usage

Type of compound

Novel and potent transient receptor potential melastatin 8 (TRPM8) antagonist

Function

Modulation of TRPM8, a cold and menthol receptor

Therapeutic applications

Potential use in pain and neurogenic inflammation

In vitro effectiveness

Effectively blocks TRPM8-mediated calcium influx

In vivo effectiveness

Reduces inflammatory and neuropathic pain in animal models

Potential implications

Treatment of conditions such as arthritis and neuropathic pain as a novel analgesic and anti-inflammatory agent.

Check Digit Verification of cas no

The CAS Registry Mumber 471905-61-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,1,9,0 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 471905-61:
(8*4)+(7*7)+(6*1)+(5*9)+(4*0)+(3*5)+(2*6)+(1*1)=160
160 % 10 = 0
So 471905-61-0 is a valid CAS Registry Number.

471905-61-0Relevant articles and documents

A practical synthesis of a γ-secretase inhibitor

Scott, Jeremy P.,Lieberman, David R.,Beureux, Olivier M.,Brands, Karel M. J.,Davies, Antony J.,Gibson, Andrew W.,Hammond, Deborah C.,McWilliams, Chris J.,Stewart, Gavin W.,Wilson, Robert D.,Dolling, Ulf-H.

, p. 4149 - 4155 (2008/02/05)

(Chemical Equation Presented) A practical and scaleable synthesis of the γ-secretase inhibitor 1 is reported. The inhibitor consists of a central trisubstituted cyclohexane core with appended propionic acid, 2,5-difluorophenyl, and 4-chlorophenylsulfonyl

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