57830-14-5

Basic information

• Product Name: 1(3H)-Isobenzofuranone, 5-phenoxy-
• Synonyms: 1(3H)-Isobenzofuranone, 5-phenoxy-;5-phenoxyisobenzofuran -1(3H)-one;5-Phenoxy-1(3H)-isobenzofuranone;1(3H)-Isobenzofuranone, 5-phenoxy- (Related Reference);5-phenoxy-3H-2-benzofuran-1-one
• CAS NO: 57830-14-5
• Molecular Formula: C₁₄H₁₀O₃
• Molecular Weight: 226.2274
• Mol File: 57830-14-5.mol

Chemical Properties

• Boiling Point: 422.467 °C at 760 mmHg
• Flash Point: 179.748 °C
• Appearance: /
• Density: 1.280
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1(3H)-Isobenzofuranone, 5-phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(3H)-Isobenzofuranone, 5-phenoxy-(57830-14-5)
• EPA Substance Registry System: 1(3H)-Isobenzofuranone, 5-phenoxy-(57830-14-5)

Safety Data

• Hazardous Substances Data: 57830-14-5(Hazardous Substances Data)

Usage

Uses

As the provided materials indicate that 1(3H)-Isobenzofuranone, 5-phenoxydoes not have any known practical applications or uses, it is not possible to list specific applications or industries where it is utilized. Further research and documentation would be required to determine its potential uses and applications.

Upstream product

• 64169-34-2 5-bromophthalide 
• 108-95-2 phenol 
• 201230-82-2 carbon monoxide 
• 2215-77-2 4-Phenoxybenzoic acid 
• 74-95-3 1,1-dibromomethane 
• 63197-24-0 4-phenoxy-N-methyl phthalimide 
• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 139-02-6 sodium phenoxide 
• 89-40-7 4-nitrophthalimide 
• 301208-03-7 4-phenoxy-phthalimide 
• 90224-73-0 5-bromo-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione 
• 41663-84-7 4-nitro-N-methyl-phthalimide 

Downstream Products

• 808118-40-3 [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid 
• 1421312-35-7 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid 
• 1455087-16-7 4-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}tetrahydropyran-4-carboxylic acid 
• 1455091-29-8 4-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}tetrahydropyran-4-carboxylic acid methyl ester 
• 1455087-12-3 1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid 
• 1455091-26-5 1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid methyl ester 
• 1455090-32-0 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid 
• 1455094-84-4 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester 
• 1455094-82-2 4-[(4-hydroxy-1-iodo-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester 
• 1455094-80-0 4-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester 
• 1455094-78-6 4-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester 
• 1455090-30-8 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid 
• 1455094-75-3 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester 
• 1455094-73-1 3-[(4-hydroxy-1-iodo-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester 

Relevant articles and documents

Synthesis of 5-phenoxyisobenzofuran-1(3H)-one as a key intermedate of the drug roxadustat

In this paper, a novel synthetic route to the key intermediate of the drug Roxadustat, 5-phenoxyisobenzofuran-1(3H)-one, was achieved in two steps in overall 78percent yield by using (3-phenoxyphenyl) methanol as the starting material. The synthetic route has the advantages of fewer steps, good regioselectivity, low catalyst consumption, high yield and lower raw material costs which are beneficial to realize industrial production.

Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-π interactions and not the previously considered cation/π-π interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

Preparation method of isoquinoline derivative

Disclosed is a preparation method of an isoquinoline derivative. A preparation method of a compound represented by a general formula II, i.e., 4-hydroxy-1-methyl-7-phenoxy isoquinoline-3-formate, is provided, wherein substituent definitions are as defined in the specification. The preparation method comprises the following steps of: under an acidic condition, dissolving a compound shown as a structural formula III in dimethyl sulfoxide, catalyzing by a ferrous ion (Fe) catalyst, and oxidizing by H2O2 to obtain the 4-hydroxy-1-methyl- 7-phenoxy isoquinoline-3-formate shown as the structuralformula II. By using the method, the production efficiency can be greatly improved, the production cost is reduced, the product purity can be ensured, and the method is suitable for industrial mass production.

Indium-Catalyzed C?F Bond Transformation through Oxymetalation/β-Fluorine Elimination to Access Fluorinated Isocoumarins

Fluorinated heterocycles have attracted much attention in the pharmaceutical and agrochemical industries. Many strategies have already been developed to achieve the synthesis of fluorinated heterocycles. Formidable challenges remain, however, in the synthesis of fluorinated isocoumarin derivatives that are among the most alluring structural motifs. Herein, the indium-catalyzed C?F bond transformation of 2-(2,2-difluorovinyl) benzoates is reported, which are readily accessible compounds, to give a diverse array of fluorinated isocoumarins. The present reaction proceeds smoothly using inexpensive reagents: a catalytic amount of indium salt in the presence of zinc salt. A theoretical calculation of potential energy profiles showed that the reaction consists of oxymetalation with the elimination of alkyl halide and the β-fluorine elimination.

IMPROVED PROCESS FOR THE PREPARATION OF ROXADUSTAT

A synthetic route for the preparation of Roxadustat, or a pharmaceutically acceptable salt thereof. Each route involves several novel intermediates and avoids the use of column chromatography.

Isoquinolone compound and application thereof

The invention relates to an isoquinolone compound and application thereof. The invention in particular relates to an isoquinolone compound used as a HIF prolyl hydroxylase inhibitor (HIF-PHI) and a pharmaceutical composition thereof. Moreover, the present invention provides the application of the isoquinolinone compound or the pharmaceutical composition thereof in the preparation of a medicament for preventing or treating HIF-associated or HIF-mediated diseases as anemia or ischemia, local ischemia or hypoxia.

Preparation method for substituting phthalide compound and intermediate of preparation method

The invention discloses a preparation method for substituting a phthalide compound and an intermediate of the preparation method. The preparation method for substituting the phthalide compound comprises the following step that in water, the compound B is

PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS

The present invention relates to methods for making isoquinoline compounds and the intermediate compounds achieved thereby. Such compounds can be used to prepare compounds and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).