611-81-4

Basic information

• Product Name: Methanone, (3-hydroxyphenyl)(4-hydroxyphenyl)-
• CAS NO: 611-81-4
• Molecular Formula: C13H10O3
• Molecular Weight: 214.221
• Mol File: 611-81-4.mol

Chemical Properties

• CAS DataBase Reference: Methanone, (3-hydroxyphenyl)(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (3-hydroxyphenyl)(4-hydroxyphenyl)-(611-81-4)
• EPA Substance Registry System: Methanone, (3-hydroxyphenyl)(4-hydroxyphenyl)-(611-81-4)

Safety Data

• Hazardous Substances Data: 611-81-4(Hazardous Substances Data)

Upstream product

• 10401-11-3 3-hydroxy phenylacetylene 
• 108-95-2 phenol 
• 99-06-9 3-Carboxyphenol 
• 98-95-3 nitrobenzene 
• 1469-74-5 3,4'-dinitrobenzophenone 
• 3002-33-3 4-(3'-nitrobenzyl)-nitrobenzene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 1711-05-3 m-anisoyl chloride 
• 28281-76-7 5-methoxyisobenzofuran-1,3-dione 
• 51458-66-3 3,4'-diamino benzophenone 
• 108837-28-1 4-methoxy-2-(4-methoxy-benzoyl)-benzoic acid 
• 65853-67-0 3-methoxybenzoic acid phenyl ester 
• 75731-44-1 4,3'-dimethoxybenzophenone 

Downstream Products

• 1351533-22-6 C₂₅H₁₆N₂O₇ 
• 118570-55-1 3,4'-bis(4-aminophenoxy)-benzophenone 
• 1000073-53-9 2-ferrocenyl-1-(3-hydroxyphenyl)-1-(4-hydroxyphenyl)-but-1-ene 
• 263395-59-1 (E)-1-{4'-[2-(N,N-dimethylamino)ethoxy]phenyl}-1-[3-(trimethylacetoxy)phenyl]-2-phenylbut-1-ene 
• 263395-58-0 (E)-1-(4'-hydroxyphenyl)-1-[3-(trimethylacetoxy)phenyl]-2-phenylbut-1-ene 
• 263395-64-8 4'-[2-(N,N-dimethylamino)ethoxy]-3-(trimethylacetoxy)benzophenone 
• 263395-56-8 4'-methoxymethoxy-3-(trimethylacetoxy)benzophenone 
• 263395-57-9 4'-hydroxy-3-(trimethylacetoxy)benzophenone 
• 263395-65-9 4'-[2-(N,N-dimethylamino)ethoxy]-3-hydroxybenzophenone 
• 83647-29-4 1-(4-[2-dimethylaminoethoxy]phenyl)-1-(3-hydroxyphenyl)-2-phenylbut-1-ene 
• 82413-20-5 Droloxifene 

Relevant articles and documents

Visible Light Copper Photoredox-Catalyzed Aerobic Oxidative Coupling of Phenols and Terminal Alkynes: Regioselective Synthesis of Functionalized Ketones via C C Triple Bond Cleavage

Direct oxidative coupling of phenols and terminal alkynes was achieved at room temperature by a visible-light-mediated copper-catalyzed photoredox process. This method allows regioselective synthesis of hydroxyl-functionalized aryl and alkyl ketones from simple phenols and phenylacetylene via C C triple bond cleavage. 47 examples were presented. From a synthetic perspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical drugs, such as pitofenone and fenofibrate.

Novel organosoluble polyimide based on an asymmetric bis(ether amine): 3, 4′-Bis(4-aminophenoxy)-benzophenone

A new kind of asymmetrical ether diamine, 3,4′-bis(4-aminophenoxy) benzophenone (BABP), was synthesized from the nucleophilic substitution reaction of 4-chloronitrobenzene and 3,4′-dihydroxybenzophenone in the presence of potassium carbonate, followed by catalytic reduction with SnCl 2·6H2O and concentrated hydrochloric acid. The prepared diamine was employed in the preparation of a novel polyimide containing asymmetrical diaryl ether segments via the polycondensation of it with BTDA by a two-step method. The resulting polyimide exhibits excellent solubility, film-forming capability and high thermal resistance.

Process for producing 3,4′ diacetoxybenzophenone

A process for producing 3,4′diacetoxybenzophenone by first synthesizing 3,4′dihydroxybenzophenone by reacting meta-hydroxybenzoic acid and phenol in the presence of a Lewis acid, and a protonic acid followed by reacting the 3,4′dihydroxybenzophenone with an acetylating agent in the presence of an inorganic acid and activated carbon.

Process for producing 3,4′ dihydroxybenzophenone

A process for synthesizing 3,4′dihydroxybenzophenone by reacting meta-hydroxybenzoic acid and phenol in the presence of a Lewis acid, and a protonic acid. Upon completion of the reaction the Lewis and protonic acids are removed and then the reaction product of 3,4′dihydroxybenzophenone is contacted with water (at temperature not greater than 10° C.) and ammonium hydroxide followed by filtration.

4,4′-Benzophenone-O,O′-disulfamate: A potent inhibitor of steroid sulfatase

We investigated whether the benzophenone moiety can be used as core element of steroid sulfatase (STS) inhibitors. While 4- and 3-benzophenone-O-sulfamates inhibit STS with IC50 values between 5 and 7 μM irrespective of additional hydroxy and m

New highly stereoselective synthesis of (E)-droloxifene via selective protection of 3,4'-dihydroxybenzophenone and McMurry reaction

A new, highly stereoselective synthesis of (E)-droloxifene is reported. Deprotection of 3,4'-dimethoxybenzophenone and selective pivaloylation of the 3'-phenolic position gave 4-hydroxy-3'-(trimethylacetoxy)benzophenone. A McMurry reaction between the preceding benzophenone and propiophenone gave the (E)-olefin as a major product (14:1 E/Z ratio in crude reaction), which was then alkylated with 2-dimethylaminoethyl chloride and deprotected to yield (E)-droloxifene with a > 100:1 E/Z ratio (5 steps, 13%). Attempts to use this strategy as a suitable stereoselective method to obtain (Z)- droloxifene were not successful. (C) 2000 Elsevier Science Ltd.