629-22-1

Basic information

• Product Name: DL-A-HYDROXYSTEARIC ACID
• Synonyms: DL-A-HYDROXYSTEARIC ACID;dl-α-hydroxystearic acid
• CAS NO: 629-22-1
• Molecular Formula: C₁₈H₃₆O₃
• Molecular Weight: 300.47664
• Mol File: 629-22-1.mol

Chemical Properties

• Boiling Point: 432.6°C at 760 mmHg
• Flash Point: 229.6°C
• Appearance: /
• Density: 0.944g/cm³
• Vapor Pressure: 2.67E-09mmHg at 25°C
• Refractive Index: 1.468
• Storage Temp.: 2-8°C
• CAS DataBase Reference: DL-A-HYDROXYSTEARIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: DL-A-HYDROXYSTEARIC ACID(629-22-1)
• EPA Substance Registry System: DL-A-HYDROXYSTEARIC ACID(629-22-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 629-22-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
DL-A-HYDROXYSTEARIC ACID is used as an active pharmaceutical ingredient for its potential anti-cancer properties. It has been shown to reduce the growth of Ehrlich ascites tumor (EAT) cells in vitro when used at a concentration of 100 μM, making it a promising candidate for further research and development in cancer treatment.
Used in Orthopedics:
DL-A-HYDROXYSTEARIC ACID is used as a biomarker for joint health. Elevated levels of this compound have been observed in human joint synovial fluid after ankle fracture, which may indicate its potential use in diagnosing and monitoring orthopedic injuries.
Used in Dermatology:
In patients with Buruli ulcer disease, an increase in DL-A-HYDROXYSTEARIC ACID levels has been noted. This suggests that it could be used as a diagnostic marker or even a therapeutic agent in the treatment of skin conditions and ulcers.
Used in Cosmetics Industry:
Due to its fatty acid nature and hydroxylated structure, DL-A-HYDROXYSTEARIC ACID may be used as an ingredient in the cosmetics industry for its potential moisturizing, emollient, and skin-conditioning properties.
Used in Research:
DL-A-HYDROXYSTEARIC ACID serves as a valuable compound for scientific research, particularly in the fields of biochemistry, cell biology, and pharmacology. Its unique properties make it an interesting subject for studying cellular processes and the development of new therapeutic strategies.

InChI:InChI=1/C18H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h17,19H,2-16H2,1H3,(H,20,21)/t17-/m1/s1

Upstream product

• 142-94-9 2-bromostearic acid 
• 41753-99-5 2-chloro-octadecanoic acid methyl ester 
• 2420-35-1 2-hydroxyoctadecanoic acid methyl ester 
• 56279-49-3 2-chloro-octadecanoic acid 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 5829-46-9 9-chloro-octadecanoic acid 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 57-11-4 stearic acid 
• 3196-18-7 Methyl 2-bromostearate 

Downstream Products

• 2420-35-1 2-hydroxyoctadecanoic acid methyl ester 
• 629-90-3 n-heptadecanal 
• 7378-88-3 12-octadecenoic acid 
• 506-12-7 heptadecanoic acid 
• 56279-49-3 2-chloro-octadecanoic acid 
• 64-18-6 formic acid 
• 7732-18-5 water 
• 405167-20-6 2-acetoxy-octadecanoic acid pentafluorophenyl ester 
• 100896-30-8 (2R)-2-hydroxyoctadecanoic acid methyl ester 
• 67491-95-6 2-(2-Hydroxyethylamino)octadecanoic acid 
• 41753-99-5 2-chloro-octadecanoic acid methyl ester 

Relevant articles and documents

Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents

A series of α- and β-carboxylated phospholipid prodrugs of dideoxy nucleosides have been synthesized and evaluated against HIV. An increase in biological effect with a factor of 500 has only been observed for the adenine nucleoside, which suggests that this prodrug approach is base specific.

Cosmetic composition comprising at least one polyester resulting from esterification of at least one triglyceride of hydroxylated carboxylic acid(s) and also comprising at least one pasty compound

Disclosed herein is a cosmetic care or makeup composition comprising a) at least one polyester resulting from esterification of at least one triglyceride of at least one hydroxylated carboxylic acid with at least one aliphatic monocarboxylic acid and with at least one aliphatic dicarboxylic acid, and b) at least one pasty compound. This composition makes it possible to obtain a deposition on a keratin materials which can be lubricious, glossy, and comfortable, can have sharply defined outlines, does not migrate, and whose color intensity can be enhanced and/or whose color retention after challenge can be enhanced.

Cosmetic composition comprising at least one polyester resulting from esterification of at least one triglyceride of hydroxylated carboxylic acid(s) and at least one oil with a molar mass of 650 to 10 000 g/mol

Disclosed herein is a composition, for example, a cosmetic care and/or makeup composition for a keratin material, comprising, in a cosmetically acceptable medium, i) at least one polyester resulting from esterification of at least one triglyceride of at least one hydroxylated carboxylic acid with at least one aliphatic monocarboxylic acid and at least one aliphatic dicarboxylic acid, ii) at least one oil of a molar mass ranging from 650 to 10 000 g/mol, and iii) at least one colorant. The composition may possess cosmetic properties and can, for example, endow the makeup or care product with properties of gloss, smoothness of application and comfort. Further disclosed herein is the use of the at least one polyester and the at least one oil with a molar mass ranging from 650 to 10 000 g/mol in a physiologically acceptable composition as an agent for endowing the composition with properties of slip, gloss, comfort, definition, non-migration, enhanced color intensity and/or enhanced color retention after challenge.

Personal care compositions comprising solid particles enterapped in a gel network

The present invention relates to a personal care composition comprising a three dimensional gel polymeric network comprising: a. a polymer; b. one or more solid particles that are entrapped within said polymer during polymerization of said polymer; and c. a solvent in which said polymer is dispersed. Another embodiment further includes at least one second colorant that is substantially similar to an at least one first colorant which is a solid particle and wherein said second colorant is dispersed within said composition but is not entrapped in said polymer and is separate and distinct from said network. In contrast, a third embodiment allows for the at least one second colorant to be substantially different from the at least one first colorant.

COSMETIC COMPOSITIONS CONTAINING A SILOXANE ELASTOMER

A skin treatment composition is provided which includes a crosslinked non-emulsifying siloxane elastomer, a volatile siloxane and at least 50% by weight of water. Inclusion of the elastomer provides a unique liquid/powdery feel when rubbed into the skin.

Cosmetic compositions

The present invention relates to pigmented emulsion cosmetic compositions containing emulsifying silicone elastomers that provide a natural appearance to the skin upon application. In particular, these cosmetic compositions are formulated such that agglomeration of the pigment upon application to the skin is minimized.

Cosmetic compositions

A skin treatment composition is provided which includes a crosslinked siloxane elastomer gel of specific yield point, a skin-conditioning agent, a volatile siloxane and water. Inclusions of the select elastomers provide improved uniform distribution of the pigments.

Anhydrous cosmetic compositions

An anhydrous skin treatment composition is provided which includes a crosslinked emulsifying siloxane elastomer, at least 20% humectant and a volatile siloxane. Inclusion of the elastomer provides a non-traditional smooth/silky feel to the skin upon application with a non-draggy rub in.

Cosmetic compositions

The invention relates to cosmetic compositions comprising a combination of non-emulsifying and emulsifying crosslinked siloxane elastomers.