6309-46-2

Basic information

• Product Name: 4-(Hydroxymethyl)phenyl acetate
• Synonyms: 4-(Hydroxymethyl)phenyl acetate;Benzyl alcohol, p-hydroxy-, acetate (8CI);4-(Acetyloxy)benzenemethanol;4-Acetoxybenzyl alcohol;Acetic acid 4-hydroxymethylphenyl ester;NSC 42564;p-Acetoxybenzyl alcohol;p-Hydroxymethylphenol acetate
• CAS NO: 6309-46-2
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.1739
• Product Categories: Alcohols;Building Blocks;C9;C9 to C10;Chemical Synthesis;Ethers;New Products for Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 6309-46-2.mol

Chemical Properties

• Melting Point: 37-42℃
• Boiling Point: 110℃ (0.001 Torr)
• Flash Point: >110°C
• Appearance: /
• Density: 1.169g/mLat 25℃
• Vapor Pressure: 0.000997mmHg at 25°C
• Refractive Index: n20/D 1.529
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(Hydroxymethyl)phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Hydroxymethyl)phenyl acetate(6309-46-2)
• EPA Substance Registry System: 4-(Hydroxymethyl)phenyl acetate(6309-46-2)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 6309-46-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Reactions:
4-(Hydroxymethyl)phenyl acetate is used as a reactant in various chemical reactions due to its reactivity with a range of other substances. Its versatility in chemical processes makes it a valuable compound for synthesizing different products.
Used in Pharmaceutical Industry:
4-(Hydroxymethyl)phenyl acetate is used as an intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, contributing to advancements in medicine.
Used in Flavor and Fragrance Industry:
4-(Hydroxymethyl)phenyl acetate is used as a flavoring agent and a fragrance ingredient. Its aromatic properties make it suitable for enhancing the scent and taste of various consumer products, such as perfumes, cosmetics, and food items.
Used in Research and Development:
4-(Hydroxymethyl)phenyl acetate is used as a research compound in academic and industrial settings. Its unique chemical properties provide opportunities for studying its behavior in different reactions and exploring its potential applications in various fields.
Safety Precautions:
When handling 4-(Hydroxymethyl)phenyl acetate, it is crucial to follow safety protocols to prevent chemical accidents or hazards. Proper storage, handling, and disposal methods should be adhered to, ensuring the safety of both the compound and those who work with it.

InChI:InChI=1/C9H10O3/c1-7(11)12-9-4-2-8(6-10)3-5-9/h2-5,10H,6H2,1H3

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 
• 107866-54-6 1-acetyl-1H-1,2,3-triazolo<4,5-b>pyridine 
• 75178-12-0 2,2'-bipyridyl-6-yl acetate 
• 115287-29-1 Acetic acid 4-trimethylsilanyloxymethyl-phenyl ester 
• 52727-95-4 4-acetoxybenzyl bromide 
• 75-36-5 acetyl chloride 
• 228106-32-9 acetic acid 4-trityloxymethyl-phenyl ester 
• 878-00-2 4-formylphenyl acetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 228106-33-0 4-trityloxymethyl-phenol 
• 60-29-7 diethyl ether 
• 108-24-7 acetic anhydride 
• 2345-34-8 4-acetyloxy-benzoic acid 
• 108-05-4 vinyl acetate 

Downstream Products

• 136825-69-9 di(4-acetoxybenzyl) methylphosphonate 
• 151239-26-8 4-{[({[4-(acetyloxy)phenyl]methoxy}[bis(propan-2-yl)amino]phosphanyl)oxy]methyl}phenyl acetate 
• 52727-95-4 4-acetoxybenzyl bromide 
• 39720-27-9 4-acetoxybenzyl chloride 
• 171284-20-1 4-acetoxybenzyl N,N,N’,N’-tetraisopropylphosphoramidite 
• 878-00-2 4-formylphenyl acetate 
• 185068-44-4 di(4-acetoxybenzyl) phosphite 
• 86157-54-2 4-(acetoxy)benzyl chloroformate 
• 228106-19-2 Acetic acid 4-(2,2,2-trichloro-acetimidoyloxymethyl)-phenyl ester 
• 2937-64-6 4-(acetyloxy)benzyl acetate 
• 19260-33-4 p-acetoxybenzyl iodide 
• 91735-04-5 Acetic acid 4-nitrooxymethyl-phenyl ester 
• 133160-67-5 12β-dihydroartemisinyl p-hydroxybenzyl ether 

Relevant articles and documents

Fluorescent labeling of s2T-incorporated DNA and m5s2U-modified RNA

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The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives

A series of novel 9, 13-disubstituted berberine derivatives have been synthesized and evaluated for the antibacterial activities against Staphylococcus aureus, including Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108, and NRS-271). Compound 20 shows the most potent activity against the growth of Newman strain, with a MIC value of 0.78?μg/mL, which is comparable with the positive control vancomycin. In addition, compound 20, 21, and 33 are highly antistaphylococcal active against five strains of multidrug-resistant S.?aureus, with MIC values of 0.78–1.56?μg/mL. Of note, theses antibacterial active compounds have no obvious toxicity to the viability of human fibroblast (HAF) cells at the MIC concentration.