63951-01-9

Basic information

• Product Name: 1-PHENYL-2-AMINOPENTANE
• Synonyms: 1-PHENYL-2-AMINOPENTANE;1-Phenylpentane-2-amine;α-Propylbenzeneethanamine
• CAS NO: 63951-01-9
• Molecular Formula: C₁₁H₁₇N
• Molecular Weight: 163.26
• Mol File: 63951-01-9.mol

Chemical Properties

• Boiling Point: 247.9°C at 760 mmHg
• Flash Point: 104°C
• Appearance: /
• Density: 0.928g/cm³
• Vapor Pressure: 0.0251mmHg at 25°C
• Refractive Index: 1.517
• PKA: 10.91±0.35(Predicted)
• CAS DataBase Reference: 1-PHENYL-2-AMINOPENTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-2-AMINOPENTANE(63951-01-9)
• EPA Substance Registry System: 1-PHENYL-2-AMINOPENTANE(63951-01-9)

Safety Data

• Hazardous Substances Data: 63951-01-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 24, p. 2955, 1994 DOI: 10.1080/00397919408010616

InChI:InChI=1/C11H17N/c1-2-6-11(12)9-10-7-4-3-5-8-10/h3-5,7-8,11H,2,6,9,12H2,1H3

Upstream product

• 100-52-7 benzaldehyde 
• 105909-68-0 3-oxo-2-phenyl-hexanenitrile 
• 6683-92-7 1-phenylpentan-2-one 
• 705-73-7 1-phenyl-2-pentanol 
• 4250-81-1 1-phenyl-1-pentyne 
• 109-74-0 propyl cyanide 
• 6921-34-2 benzylmagnesium chloride 
• 1205-53-4 1-phenyl-2-nitro-1-pentene 
• 100368-82-9 2-Formamino-1-phenyl-pentan 
• 873394-19-5 4-(2-amino-pentyl)-aniline 
• 84524-54-9 1-phenyl-pentan-2-one oxime 

Downstream Products

• 139925-24-9 1-(1-Benzyl-butyl)-3-hydroxypyrrolidin-2-on 
• 139925-25-0 1-(1-Benzyl-butyl)-4-hydroxypyrrolidin-2-on 
• 119485-94-8 N-propyl-1-phenyl-2-pentylamine 
• 848135-61-5 (+/-)-N-(methoxycarbonyl)-1-phenyl-2-aminopentane 
• 101717-63-9 N-(1-benzyl-butyl)-benzamide 

Relevant articles and documents

Hybrid dopamine uptake blocker-serotonin releaser ligands: A new twist on transporter-focused therapeutics

As part of our program to study neurotransmitter releasers, we report herein a class of hybrid dopamine reuptake inhibitors that display serotonin releasing activity. Hybrid compounds are interesting since they increase the design potential of transporter related compounds and hence represent a novel and unexplored strategy for therapeutic drug discovery. A series of N-alkylpropiophenones was synthesized and assessed for uptake inhibition and release activity using rat brain synaptosomes. Substitution on the aromatic ring yielded compounds that maintained hybrid activity, with the two disubstituted analogues (PAL-787 and PAL-820) having the most potent hybrid activity.

Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors

A series of 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinolines was synthesized and these compounds were evaluated for their PNMT inhibitory potency and affinity for the α2-adrenoceptor. 7-Nitro-, 7-bromo-, 7-aminosulfonyl-, or 7-N-2,2,2-trif

Structure - Activity studies leading to ( - )1-(Benzofuran-2-yl)-2-propylaminopentane, (( - )BPAP), a highly potent, selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain

The catecholaminergic and serotoninergic neurons in the brain change their performance according to the physiological need via a catecholaminergic/serotoninergic activity enhancer (CAE/SAE) mechanism. Phenylethylamine (PEA), tyramine and tryptamine are th

An ammonia equivalent for the dimethyltitanocene-catalyzed intermolecular hydroamination of alkynes

(Equation presented) Commercially available α-aminodiphenylmethane 1 (benzhydrylamine) serves as a convenient ammonia equivalent in the dimethyltitanocene-catalyzed intermolecular hydroamination of alkynes. The primary formed imines can be hydrogenated and cleaved directly to the corresponding primary amines by catalytic hydrogenation using Pd/C as catalyst.

Probes of the Active Site of Norepinephrine N-Methyltransferase: Effect of Hydrophobic and Hydrophilic Interactions on Side-Chain Binding of Amphetamine and α-Methylbenzylamine

A series of ω-substituted analogues of amphetamine and α-methylbenzylamine were prepared and evaluated as inhibitors of norepinephrine N-methyltransferase (NMT).These included several alkyl side chain extended analogues (1-5), as well as the terminally hydroxylated derivatives phenylalanol (6a) and Phenylglycinol (7a).None of the alkyl-substituted derivatives displayed appreciable activity as inhibitors; however, the hydroxylated analogues were up to twofold more potent than the parent compounds.The positive contribution of the side-chain hydroxy suggests that theterminal methyl group of the lead compounds is situated close to a hydrophilic area or hydrogen bonding functional group within the active site.