658-07-1

Basic information

• Product Name: 2,6-Difluoro-4-nitrophenol
• Synonyms: 2,6-Difluoro-4-nitrophenol;2,6-Difluoro-4-nitrophenol 98%;3,5-Difluoro-4-hydroxynitrobenzene;4-nitro-2,6-Difluorophenol
• CAS NO: 658-07-1
• Molecular Formula: C₆H₃F₂NO₃
• Molecular Weight: 175.09
• Mol File: 658-07-1.mol

Chemical Properties

• Melting Point: 99.7-100.7°C
• Boiling Point: 254.5 °C at 760 mmHg
• Flash Point: 107.7 °C
• Appearance: /
• Density: 1.619 g/cm³
• Vapor Pressure: 0.0107mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.28±0.44(Predicted)
• CAS DataBase Reference: 2,6-Difluoro-4-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluoro-4-nitrophenol(658-07-1)
• EPA Substance Registry System: 2,6-Difluoro-4-nitrophenol(658-07-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 658-07-1(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow crystalline

InChI:InChI=1/C6H3F2NO3/c7-4-1-3(9(11)12)2-5(8)6(4)10/h1-2,10H

Upstream product

• 100-02-7 4-nitro-phenol 
• 28177-48-2 2,6-difluorophenol 
• 141-78-6 ethyl acetate 
• 5509-65-9 2,6-difluoroaniline 
• 18063-03-1 2,6-difluorobenzamide 
• 66684-58-0 3,4,5-trifluoronitrobenzene 

Downstream Products

• 392-25-6 1,3-difluoro-2-methoxy-5-nitrobenzene 
• 3828-41-9 2-chloro-1,3-difluoro-5-nitrobenzene 
• 126058-97-7 2,6-di-fluoro-4-aminophenol 
• 363-47-3 3,5-difluoro-4-methoxyaniline 
• 220353-18-4 1,3-difluoro-4-iodo-2-methoxybenzene 
• 220353-20-8 2,4-difluoro-3-methoxy-benzonitrile 
• 717094-51-4 (2,4-difluoro-3-methoxyphenyl)methanamine 
• 220353-16-2 3,5-difluoro-2-iodo-4-methoxyaniline 
• 175435-38-8 4-chloro-3-fluoro-5-methoxynitrobenzene 
• 220353-22-0 4-amino-2,6-difluorophenol hydrochloride 
• 337520-54-4 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene 

Relevant articles and documents

Novel HPK1 inhibitor as well as preparation method and application thereof

The present invention provides an HPK1 kinase inhibitor, the preparation thereof and use thereof. Specifically, the present invention provides a compound as represented by formula I. The definitions on groups are as stated in the description. The compound has excellent HPK1 inhibitory activity, and therefore can be used for preparing a pharmaceutical composition for treating cancer and other diseases related to HPK1 activity.

SUBSTITUTED PYRROLOPYRIDINE-DERIVATIVES

The present invention relates to protein-inhibitory substituted pyrrolopyridine derivatives of formula (I) in which A, X, R1a, R1b, R2, R3a, R3b, R4a and R4b are as defined herein, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, repectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients. The present invention further relates to the use, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control.

A aqueous phase preparation 2, 6 - [...] method

The invention relates to a green preparation 2, 6 - [...] synthetic method, to industrial product is 2, 6 - difluoro-benzamide as the starting material, passes through the aqueous phase Huffman degradation reaction, the aqueous phase diazotisations directly after the hydrolysis, direct concentrated nitric acid nitration, the iron powder reduces the aqueous phase, the aqueous phase with the aqueous phase to diazotization coupling reaction of phenol, after five step process for preparing aqueous phase reactions 2, 6 - [...] production process and corresponding various process conditions. The beneficial effect of the present invention is: select industrialized product 2, 6 - difluoro-benzamide as the raw material, raw materials are easy, low cost, through the aqueous phase reaction and solvent-free reaction for the preparation of 2, 6 - [...], its mild reaction conditions and environmental, safety and high efficiency. The present invention provides a kind of environmental protection, model, high efficiency can be used for the industrial production of 2, 6 - [...] green synthetic pathway.

Method for preparing 2,6-difluoroindophenol acetate

The invention relates to a novel synthetic method for preparing 2,6-difluoroindophenol acetate, in particular to a production process for preparing the 2,6-difluoroindophenol acetate successively by virtue of six reaction steps of industrialized product 2,6-difluorobenzamide serving as a raw material, i.e. Hofmann degradation reaction, diazotization and direct hydrolysis, nitrification with concentrated nitric acid, catalytic hydrogenation reduction with palladium on carbon, diazotization and phenol coupling reaction and esterification under the condition of acetic anhydride and various corresponding process conditions. The method has the beneficial effects that the industrialized product 2,6-difluorobenzamide is used as the raw material, the raw material is easy to obtain, the price is low, and the reaction condition is mild and environmentally friendly. The invention provides a novel efficient way for producing the 2,6-difluoroindophenol acetate in an industrialization manner.

Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Br?nsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.

Elemental fluorine. Part 20. Direct fluorination of deactivated aromatic systems using microreactor techniques

Continuous flow microreactor technology has been used for the direct fluorination of a range of deactivated di- and tri-substituted aromatic systems.

Synthesis of COX-2 and FAAH inhibitors

Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.

BENZAMIDINE DERIVATIVES

Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: wherein R 1represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2represents a hydrogen atom, a halogen atom or an alkyl group, R 3represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6represents a substituted pyrrolidine group or substituted piperidine group.

Elemental fluorine Part 12. Fluorination of 1,4-disubstituted aromatic compounds

Direct fluorination of a series of 1,4-disubstituted benzene derivatives in acid reaction media at convenient temperature leads, in many cases, to selectively fluorinated aromatic products in preparatively useful conversions and yields.

2,6-difluorophenol as a bioisostere of a carboxylic acid: Bioisosteric analogues of γ-aminobutyric acid

3-(Aminomethyl)-2,6-difluorophenol (6) and 4-(aminomethyl)-2,6- difluorophenol (7) were synthesized in eight and four steps, respectively, starting from 2,6-difluorophenol, to test the potential of the 2,6- difluorophenol moiety to act as a lipophilic bio