6945-92-2

Basic information

• Product Name: Ethyl hydrazinoacetate hydrochloride
• Synonyms: ETHYL HYDRAZINOACETATE HCL;ETHYL HYDRAZINOACETATE HYDROCHLORIDE;ETHYL HYDRAZINEACETATE HCL;HYDRAZINO-ACETIC ACID ETHYL ESTER HYDROCHLORIDE;ETHYL HYDRAZINOACETATE HYDROCHLORIDE, 97 %;HYDRAZINO-ACETIC ACID ETHYL ESTER HCL;EthylHydrzinocetateHydrochloride;Acetic acid, hydrazino-, ethyl ester, monohydrochloride
• CAS NO: 6945-92-2
• Molecular Formula: C₄H₁₀N₂O₂*ClH
• Molecular Weight: 154.6
• EINECS: 230-104-3
• Product Categories: Miscellaneous;Hydrazines;Nitrogen Compounds;Organic Building Blocks;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;COOR
• Mol File: 6945-92-2.mol

Chemical Properties

• Melting Point: 152-154 °C(lit.)
• Boiling Point: 223 °C at 760 mmHg
• Flash Point: 88.6 °C
• Appearance: Clear colorless to pale yellow/Liquid
• Vapor Pressure: 0.0988mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• BRN: 3912112
• CAS DataBase Reference: Ethyl hydrazinoacetate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl hydrazinoacetate hydrochloride(6945-92-2)
• EPA Substance Registry System: Ethyl hydrazinoacetate hydrochloride(6945-92-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6945-92-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl hydrazinoacetate hydrochloride is used as a precursor in the synthesis of pharmaceutical compounds for various therapeutic applications. Its reactivity and ability to form condensation derivatives make it a valuable component in the development of new drugs.
Used in Chemical Research:
In the field of chemical research, Ethyl hydrazinoacetate hydrochloride is utilized as a starting material for the preparation of novel copper(II) complexes. These complexes are formed as condensation derivatives of 2-pyridinecarboxaldehyde, 2-acetylpyridine, and 2-quinolinecarboxaldehyde, showcasing the compound's potential in creating new chemical entities with potential applications in various industries.

InChI:InChI=1/C4H10N2O2.ClH/c1-2-8-4(7)3-6-5;/h6H,2-3,5H2,1H3;1H

Upstream product

• 14150-64-2 hydrazineacetic acid 
• 3842-39-5 (N'-tert-butoxycarbonyl-hydrazino)acetic acid ethyl ester 

Downstream Products

• 10598-87-5 Ethyl-1-(5-nitro-furfuryliden)-2-semicarbazido-acetat 
• 6301-02-6 1-aminohydantoin 
• 14556-34-4 1-benzylideneamino-2-thioxo-imidazolidin-4-one 
• 10158-72-2 <6-Hydroxy-pyridazinon-(3)>-essigsaeure-(2) 
• 742017-39-6 Ethyl-(2-isopropyl-hydrazino)-acetat 
• 126081-03-6 [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester 
• 4503-58-6 benzyl 2-(2-ethoxy-2-ethoxyethyl)-1-hydrazinecarboxylate 
• 4467-44-1 N^α-Benzyloxycarbonyl-hydrazinoessigsaeure-ethylester 
• 63981-22-6 3-(5-nitrofurfurylideneamino)hydantoic acid 
• 73556-57-7 2-(ethoxycarbonylmethyl-hydrazono)-O⁵,O⁶-isopropylidene-O⁸-trityl-D-allo-4,7-anhydro-2,3-dideoxy-octonic acid methyl ester 
• 74361-83-4 2-amino-5-hydroxy-3-phenylazoimidazo<1,2-b>pyrazole 
• 84661-16-5 [3-Methyl-5-(2-nitro-phenyl)-pyrazol-1-yl]-acetic acid 
• 84661-19-8 [3-Methyl-5-(2-nitro-phenyl)-pyrazol-1-yl]-acetic acid ethyl ester 
• 58112-51-9 ethyl 2-[3-(4-methylphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]acetate 

Relevant articles and documents

Synthesis method of ethyl hydrazino-acetate hydrochloride

The invention discloses a synthesis method of ethyl hydrazino-acetate hydrochloride. The synthesis method comprises following steps: step one, in a pressure vessel, taking ethyl glyoxalate as the primary raw material, and carrying out reactions between ethyl glyoxalate and hydrazine hydrate in a solvent for 30 minutes to 5 hours to prepare ethyl hydrazo-acetate; step two, after reactions of the step one, adding a catalyst into the reaction solution, carrying out reactions for 0.5 to 24 hours at a reaction temperature of 20 to 100 DEG C to obtain ethyl hydrazino-acetate; and step three, carrying out salt forming reactions to obtain the target product namely ethyl hydrazino-acetate hydrochloride. The used reagents and solvents all meet the common industrial standards. The synthesis method issuitable for industrial large-scale production, generates little environmental pollution, and does not generate a large amount of wastewater, waste solids, and waste gas, furthermore, the operation is very safe, the post treatment is simple and easy to perform, the yield is high, and the cost is low. Reactions of two steps are carried out in one pot, and the production becomes easy.

Preparation method of ethyl hydrazinoacetate hydrochloride

The invention discloses a preparation method of ethyl hydrazinoacetate hydrochloride, which belongs to the technical field of organic synthesis. The preparation method is characterized by comprisingthe following steps: using ethyl chloroacetate or ethyl bromoacetate as an initial material to react with tert-Butyl carbazate, generating a tertiary butyl protective group, removing the protection, forming hydrochloric salt, and thus obtaining ethyl hydrazinoacetate hydrochloride. The preparation method has the advantages of mild reaction condition, high yield, high purity, low cost, economy, environmental protection, applicability to industrialization and the like, and is a synthetic method with industrial production value.