- Supramolecular structures of three isomeric 4-(methylphenylamino)-pyridine- 3-sulfonamides
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The structures of the three title isomers, namely 4-(2-methylanilino) pyridine-3-sulfonamide, (I), 4-(3-methylanilino)pyridine-3-sulfonamide, (II), and 4-(4-methylanilino)-pyridine-3-sulfonamide, (III), all C12H 13N3O2S, differ in their hydrogen-bonding arrangements. In all three molecules, the conformation of the 4-aminopyridine-3-sulfonamide moiety is conserved by an intramolecular N-H...O hydrogen bond and a C-H...O interaction. In the supramolecular structures of all three isomers, similar C(6) chains are formed via intermolecular N-H...N hydrogen bonds. N-H...O hydrogen bonds lead to C(4) chains in (I), and to R22(8) centrosymmetric dimers in (II) and (III). In each isomer, the overall effect of all hydrogen bonds is to form layer structures.
- Hulita, Nada Kosutic,Danilovski, Aleksandar,Filic, Darko,Marinkovic, Marina,Mestrovic, Ernest,Dumic, Miljenko
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- PREPARATION OF TORASEMIDE
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The stable polymorphic form of torasemide, Modification I, is prepared from other, less stable torasemide forms, by forming a solution of the starting polymorphic form of torasemide in water and methanol, stirring for at least 20 hours and then phase separating the solid torasemide modification I from the liquid medium.
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- PROCESS FOR THE PREPARATION OF HIGHLY PURE TORSEMIDE
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The present invention provides a novel process for the preparation of highly pure torsemide [1] by reacting of 4-m-tolylamino-3-pyridinesulfonamide [2] with phenyl isopropylcarbamate in the presence of lithium base (F I, II). The present invention also provides a novel intermediate - torsemide lithium, also in hydrate or solvate form - which is a stable, solid compound, and may be simply isolated from the reaction mixture to give after acidification practically pure torsemide [1] without further purification steps.
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Page/Page column 33-34; 40-41
(2010/02/07)
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- Preparation of derivative of 3-sulfonamido-4-phenylaminopyridine
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This invention relates to the preparation of 3-sulfonamido-4-arylaminopyridines by heating a 3-sulfonamido-4-aminopyridine with an aryl halide in the presence of an alkaline compound, a copper-containing agent and in the presence of a polar protic solvent.
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