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| CAS No.: | 72811-73-5 |
|---|---|
| Name: | 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide |
| Article Data: | 5 |
| Cas Database | |
| Molecular Structure: | |
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| Formula: | C12H13N3O2S |
| Molecular Weight: | 263.32 |
| Synonyms: | 3-Sulfonamido-4-(3-methylanilino)pyridine;BM 960102;4-(3-methylphenyl)amino-3-pyridine sulfonamide; |
| EINECS: | 615-805-8 |
| Density: | 1.357 g/cm3 |
| Melting Point: | 162-164oC |
| Boiling Point: | 475.8 °C at 760 mmHg |
| Flash Point: | 241.5 °C |
| Hazard Symbols: | Xi |
| Risk Codes: | 36 |
| Safety: | 26 |
| PSA: | 93.46000 |
| LogP: | 3.63510 |
- 72812-34-1Hydrogen (1-((2-hydroxy-4-nitrophenyl)azo)-2-naphtholato(2-))(1-((2-hydroxy-5-nitrophenyl)azo)-2-naphtholato(2-))chromate(1-) , compound with 3-((2-ethylhexyl)oxy)propylamine (1:1)
- 72816-14-95-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile
- 72816-87-62,4(1H,3H)-Pyrimidinedione, 6-amino-5-bromo-1-(phenylmethyl)-
- 72816-89-86-AMINO-1-BENZYL-5-(N-FORMYL-N-METHYL)URACIL
- 72816-91-26-AMINO-1-BENZYL-3-METHYL-5-(N-FORMYL-N-METHYL)URACIL
- 72822-12-91,2,4-Triazolo[4,3-a]pyridine,5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-
- 72822-13-01,2,4-Triazolo[4,3-a]pyridine,5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-,hydrochloride (1:1)
- 728-22-32,1-Benzisoxazole,5-chloro-3-(4-methoxyphenyl)-
- 72824-04-51,3,2-Dioxaborolane,4,4,5,5-tetramethyl-2-(2-propen-1-yl)-
- 33263-43-3
4-chloropyridine-3-sulphonamide
- 108-44-1
1-amino-3-methylbenzene
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
| Conditions | Yield |
|---|---|
| In methanol at 39.85℃; for 3h; | 96.5% |
| In propan-1-ol for 5h; Heating; | |
| In water at 80 - 90℃; for 1 - 1.5h; Product distribution / selectivity; | |
| Stage #1: 4-chloropyridine-3-sulphonamide; 1-amino-3-methylbenzene In water for 0.5h; Heating / reflux; Stage #2: With sodium hydroxide In water at 20 - 35℃; Stage #3: With sulfuric acid In water Product distribution / selectivity; |
- 777854-85-0
4-chloro-3-pyridinesulfonamide hydrochloride
- 108-44-1
1-amino-3-methylbenzene
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
| Conditions | Yield |
|---|---|
| Stage #1: 4-chloro-3-pyridinesulfonamide hydrochloride; 1-amino-3-methylbenzene In water at 90℃; for 3h; Stage #2: With sodium hydrogencarbonate In water at 20℃; pH=7 - 8; | 92% |
- 625-95-6
3-Iodotoluene
- 75903-62-7
3-sulfonamido-4-aminopyridine
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
| Conditions | Yield |
|---|---|
| With copper; potassium carbonate In butan-1-ol | 53.1% |
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
- 1795-48-8
Isopropyl isocyanate
| Conditions | Yield |
|---|---|
| Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine With sodium hydride In tetrahydrofuran; toluene at 5 - 20℃; for 16h; Stage #2: Isopropyl isocyanate In tetrahydrofuran; toluene at 20℃; Stage #3: Isopropyl isocyanate With sodium hydride; acetic acid more than 3 stages; | 100% |
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
- 1795-48-8
Isopropyl isocyanate
- 56211-40-6
torasemide
| Conditions | Yield |
|---|---|
| Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine; Isopropyl isocyanate With potassium carbonate In diethylene glycol dimethyl ether; water at 65 - 70℃; for 0.583333h; Stage #2: With acetic acid In diethylene glycol dimethyl ether; water at 20 - 25℃; for 3h; pH=5.3 - 5.7; | 96.5% |
| Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine; Isopropyl isocyanate With sodium hydroxide In acetone at 20 - 30℃; Stage #2: With acetic acid In water; acetone at 20 - 25℃; for 0.25h; pH=5.3 - 5.7; | 96% |
| Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine; Isopropyl isocyanate With sodium hydroxide In acetone at 20 - 30℃; Stage #2: With acetic acid In water; acetone at 20 - 25℃; for 0.25h; pH=5.5; | 96% |
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
- 1795-48-8
Isopropyl isocyanate
| Conditions | Yield |
|---|---|
| With sodium hydroxide In acetone at 5 - 20℃; for 2h; Reagent/catalyst; | 94.5% |
- 17614-10-7
phenyl N-isopropylcarbamate
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
- 56211-40-6
torasemide
| Conditions | Yield |
|---|---|
| Stage #1: phenyl N-isopropylcarbamate; 3-sulfonamido-4-(3'-methylphenyl) aminopyridine With triethylamine In water; acetone for 3h; Heating / reflux; Stage #2: With sodium hydroxide In water at 20 - 25℃; Stage #3: With sulfuric acid In water; acetone at 50 - 55℃; for 1h; Product distribution / selectivity; | 87.8% |
| Stage #1: phenyl N-isopropylcarbamate; 3-sulfonamido-4-(3'-methylphenyl) aminopyridine With sodium hydroxide In water at 90 - 100℃; for 5h; Stage #2: With sulfuric acid In water at 20 - 70℃; for 1h; Product distribution / selectivity; | 85% |
| Stage #1: 3-sulfonamido-4-(3'-methylphenyl) aminopyridine With sodium hydroxide In water at 20 - 35℃; Stage #2: phenyl N-isopropylcarbamate In water; acetone at 50 - 60℃; for 20h; Stage #3: With sulfuric acid In water at 15 - 50℃; for 3h; pH=7.0; Product distribution / selectivity; |
- 541-41-3
chloroformic acid ethyl ester
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
- 72810-57-2
[4-(3-methyl-anilino)-pyridine-3-sulfonyl]-carbamic acid ethyl ester
| Conditions | Yield |
|---|---|
| With pyridine for 0.333333h; Heating; | 75% |
| In tetrahydrofuran for 8h; Ambient temperature; |
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
- 5848-27-1
N-cyano-N'-isopropyl-S-methylcarbamimidothioate
| Conditions | Yield |
|---|---|
| With sodium hydroxide In 1,4-dioxane; N,N-dimethyl-formamide for 6h; Heating; | 37% |
- 72811-73-5
3-sulfonamido-4-(3'-methylphenyl) aminopyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 75 percent / pyridine / 0.33 h / Heating 2: 37 percent / toluene / 5 h / Heating View Scheme |
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Chemistry
Empirical Formula: C12H13N3O2S
Molecular Weight: 263.3155g/mol
Structure of 3-Pyridinesulfonamide,4-[(3-methylphenyl)amino]- (CAS NO.72811-73-5):
Index of Refraction: 1.641
Molar Refractivity: 69.97 cm3
Molar Volume: 193.9 cm3
Polarizability: 27.73×10-24cm3
Surface Tension: 63.3 dyne/cm
Density: 1.357 g/cm3
Flash Point: 241.5 °C
Enthalpy of Vaporization: 73.94 kJ/mol
Boiling Point: 475.8 °C at 760 mmHg
Vapour Pressure: 3.23E-09 mmHg at 25°C
Product Categories: INTERMEDIATESOFTORASEMIDE;Pyridines derivates;(intermediate of torasemide);Pyridines;Torsemide
Systematic Name: 4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
SMILES: O=S(=O)(c2c(Nc1cc(ccc1)C)ccnc2)N
InChI: InChI=1/C12H13N3O2S/c1-9-3-2-4-10(7-9)15-11-5-6-14-8-12(11)18(13,16)17/h2-8H,1H3,(H,14,15)(H2,13,16,17)
InChIKey: ZXPCUGWAKUIOOF-UHFFFAOYAX
Specification
3-Pyridinesulfonamide,4-[(3-methylphenyl)amino]- , its cas register number is 72811-73-5. It also can be called ; 4-[(3-Methylphenyl)amino]pyridine-3-sulfonamide ; 3-Sulfonamido-4-(3-methylanilino)pyridine ; 4-(3-Methylphenyl)amino-3-Pyridine Sulfonamide ; 4-(3-toluidino)pyridine-3-sulfonamide .