733-83-5

Basic information

• Product Name: BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL
• Synonyms: 1,1-BIS(4(FLUOROPHENYL)TRIFLUOROETHANOL);BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL;2,2,2-trifluoro-1,1-bis(4-fluorophenyl)ethanol;Bis(4-fluorophenyl)trifluoromethylcarbinol97%
• CAS NO: 733-83-5
• Molecular Formula: C₁₄H₉F₅O
• Molecular Weight: 288.21
• Mol File: 733-83-5.mol

Chemical Properties

• Boiling Point: 111-114°C 3mm
• Flash Point: >110°C
• Appearance: /
• Density: 1.382 g/cm³
• Vapor Pressure: 9.97E-05mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL(733-83-5)
• EPA Substance Registry System: BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL(733-83-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 733-83-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL is used as a chemical intermediate for the synthesis of pharmaceutical compounds due to its unique reactivity and ability to form carbon-carbon and carbon-heteroatom bonds, which are essential in creating complex molecular structures.
Used in Agrochemical Industry:
In the agrochemical sector, BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL is employed as a precursor in the development of new agrochemicals, leveraging its chemical properties to enhance the effectiveness of these products.
Used in Organic Chemistry Research:
BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL is used as a reagent in organic chemistry for facilitating the formation of carbon-carbon and carbon-heteroatom bonds, which are crucial in the synthesis of a wide range of organic molecules.
Used in Chemical Synthesis Processes:
As a valuable building block, BIS(4-FLUOROPHENYL)TRIFLUOROMETHYL CARBINOL is utilized in various chemical synthesis processes to create organic molecules that are important in research and development, underpinning the creation of new materials and compounds with potential applications across different industries.

InChI:InChI=1/C14H9F5O/c15-11-5-1-9(2-6-11)13(20,14(17,18)19)10-3-7-12(16)8-4-10/h1-8,20H

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 352-13-6 4-flourophenylmagnesium bromide 
• 407-25-0 trifluoroacetic anhydride 
• 345-92-6 4,4'-Difluorobenzophenone 
• 345959-36-6 1-(4-benzylpiperazin-1-yl)-2, 2, 2-trifluoroethanol 
• 75-46-7 trifluoromethan 
• 1586-73-8 tris(trimethylsilyl)amine 

Downstream Products

• 789-03-7 1,1,1-trifluoro-2,2-bis(p-fluorophenyl)ethane 
• 2247-78-1 N-<1,1-Bis-(4-fluor-phenyl)-2,2,2-trifluor-aethyl>-acetamid 
• 192826-37-2 toluene-4-sulfonic acid 2,2,2-trifluoro-1,1-bis-(4-fluoro-phenyl)-ethyl ester 
• 361-63-7 2,2-bis(4-fluorophenyl)acetic acid 
• 386-99-2 ethyl 2,2-bis(4-fluorophenyl)acetate 

Relevant articles and documents

Trifluoromethylation of nonenolizable carbonyl compounds with a stable piperazino hemiaminal of trifluoroacetaldehyde

A new stable hemiaminal of fluoral (1) can easily be obtained from the methyl hemiketal of fluoral and N-benzylpiperazine. This white crystalline compound can be used under basic conditions as an efficient nucleophilic trifluoromethylating reagent towards nonenolizable carbonyl compounds.

Nucleophilic trifluoromethylation of carbonyl compounds and disulfides with trifluoromethane and silicon-containing bases

Provided that DMF (or another N,N-dialkylformamide) is present in the reaction medium, at least in a catalytic amount, fluoroform trifluoromethylates efficiently carbonyl compounds, even enolizable ones, when opposed to (TMS)2N- M+, generated in situ from N(TMS)3 and M+ F- or RO- Na+. When F- is used in a catalytic amount, silylated α-(trifluoromethyl)carbinols are obtained: In this case, the four-component system HCF3/N(TMS)3/catalytic F-/catalytic DMF behaves like the Ruppert's reagent, especially as far as nonenolizable carbonyl compounds are concerned (CF3SiMe3 remains more efficient for enolizable carbonyl compounds). This process involves an adduct between DMF and -CF3 which is the true trifluoromethylating agent. In the same way, fluoroform efficiently trifluoromethylates disulfides and diselenides when deprotonated with a strong base selected from t-BuOK or N(SiMe3)3/Me4NF (or TBAT). t-BuOK is more adapted to the trifluoromethylation of awl disulfides whereas N(SiMe3)3/F- is Well suited to that of aliphatic disulfides.

Substituent Effects on the Solvolysis of 1,1-Diphenyl-2,2,2-trifluoroethyl Tosylates: Comparison between Symmetrically Disubstituted and Monosubstituted Systems

The solvolysis rates of 1-(substituted phenyl)-1-phenyl-2,2,2-trifluoroethyl and 1,1-bis(substituted phenyl)-2,2,2-trifluoroethyl tosylates or bromides were conductimetrically measured at 25.0 °C in 80% aqueous ethanol. The substituent effects on these so