786-31-2

Basic information

• Product Name: 2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE
• Synonyms: 4-METHYLBENZENESULFONIC ACID 2,2,3,3-TETRAFLUOROPROPYL ESTER;2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE;2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULPHONATE;2,2,3,3-TETRAFLUOROPROPYL P-TOLUENESULFONATE;2,2,3,3-TETRAFLUOROPROPYL TOSYLATE;1-Propanol, 2,2,3,3-tetrafluoro-, 1-(4-methylbenzenesulfonate);2,2,3,3-Tetrafluoropropyl 4-methylbenzenesulfonate;2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFOTE
• CAS NO: 786-31-2
• Molecular Formula: C₁₀H₁₀F₄O₃S
• Molecular Weight: 286.24
• Mol File: 786-31-2.mol

Chemical Properties

• Melting Point: 13-16°C
• Boiling Point: 134 °C
• Flash Point: >110°C
• Appearance: /
• Density: 1,4 g/cm3
• Vapor Pressure: 0.000162mmHg at 25°C
• Refractive Index: 1.4602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE(786-31-2)
• EPA Substance Registry System: 2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE(786-31-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 786-31-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE is used as a protecting group for [application reason] in organic synthesis, facilitating the formation of carbon-carbon and carbon-heteroatom bonds.
Used in Pharmaceutical Production:
2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE is used as a coupling agent for [application reason] in the production of pharmaceuticals, contributing to the development of new drugs and improving the efficiency of synthesis processes.
Used in Agrochemical Production:
2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE is used as a reagent for [application reason] in the production of agrochemicals, aiding in the synthesis of effective compounds for agricultural applications.
Used in Functional Materials Production:
2,2,3,3-TETRAFLUOROPROPYL 4-TOLUENESULFONATE is used as a key component for [application reason] in the production of functional materials, enhancing the properties and performance of these materials in various industries.

InChI:InChI=1/C10H10F4O3S/c1-7-2-4-8(5-3-7)18(15,16)17-6-10(13,14)9(11)12/h2-5,9H,6H2,1H3

Upstream product

• 41578-54-5 sodium 2,2,3,3-tetrafluoropropan-1-olate 
• 98-59-9 p-toluenesulfonyl chloride 
• 76-37-9 2,2,3,3-tetrafluoropropanol 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 

Downstream Products

• 164021-52-7 Toluene-4-sulfonic acid (Z)-2,3,3-trifluoro-1-methyl-propenyl ester 
• 60598-17-6 1,1,2,2-tetrafluoro-3-methoxypropane 
• 444916-51-2 1-methyl-3-(2,2,3,3-tetrafluoropropoxy)benzene 
• 133487-66-8 3-(2,2,3,3-tetrafluoropropoxy)benzaldehyde 
• 103962-17-0 4-(2,2,3,3-tetrafluoropropoxy)-benzaldehyde 
• 205521-85-3 benzyl 2,2,3,3-tetrafluoropropyl sulfide 
• 663-69-4 1H,1H,3H-Tetrafluorpropylamin 
• 679-87-8 1-iodo-1,1,3-trihydroperfluoropropane 
• 679-84-5 1-bromo-2,2,3,3-tetrafluoropropnae 

Relevant articles and documents

Method for preparing hydrofluoroether through two-step process

The invention discloses a method for preparing hydrofluoroether through a two-step process. With the method provided by the invention, p-toluensulfonyl chloride and fluorine-containing alcohol are subjected to a reaction to obtain p-toluenesulfonate, and the p-toluenesulfonate and sodium alkoxide are subjected to a Williamson ether synthetic reaction to obtain the hydrofluoroether. The method disclosed by the invention has the advantages of cheap and low-toxicity raw materials, mild and controllable reaction conditions, and high yield.

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor complex, JAK inhibition may offer an alternate small molecule approach to disrupting IL-13 signaling. Herein we demonstrate that JAK1 is likely the isoform most important to IL-13 signaling. Structure-based design was then used to improve the JAK1 potency of a series of previously reported JAK2 inhibitors. The ability to impede IL-13 signaling was thereby significantly improved, with the best compounds exhibiting single digit nM IC50’s in cell-based assays dependent upon IL-13 signaling. Appropriate substitution was further found to influence inhibition of a key off-target, LRRK2. Finally, the most potent compounds were found to be metabolically labile, which makes them ideal scaffolds for further development as topical agents for IL-13 mediated diseases of the lungs and skin (for example asthma and atopic dermatitis, respectively).

Anti-artz sea silent sickness drug Lu - AE - 58054 preparation method (by machine translation)

The invention discloses a novel method for preparing a medicine Lu-AE-58054 for resisting an alzheimer's disease. The novel method comprises the following steps: firstly, reacting 2,2,3,3-tetrafluoromethane-1-propyl alcohol with paratoluensulfonyl chlorid

Synthesis and physical properties of new fluoroether sulfones

Eight new strategically designed fluoroether sulfone solvents have been synthesized through different synthetic pathways for potential applications in lithium-sulfur battery electrolytes. The structures of these compounds have been confirmed by 1H-NMR, 13C-NMR and elemental analysis. Several 1,2-dimethoxyethane (DME)-based electrolyte formulations have been prepared with these solvents to derive an electrolyte with good ionic conductivity (>5 mS cm?1 at 25 ℃). The viscosity of these new additives has also been determined as it is directly related to the ionic conductivity. Three of these solvents that contain a trifluoromethyl group displayed acceptable ionic conductivity.

PROCESS FOR THE MANUFACTURE OF IDALOPIRDINE

Disclosed herein is a process for the preparation of idalopirdine and pharmaceutically acceptable salts thereof.

Alternative synthetic routes to hydrofluoroolefins

A series of hydrofluoroolefins with -CF=CH2, -CH=CHF and -CH=CF2 groups were designed and prepared via various synthetic routes, including HX or BrF elimination, Wittig-type olefination or fluorination using SF4.

Highly stereoselective approach to 3-fluoroalkylated (E)-hex-3-ene-1,5- diyne derivatives via an addition-elimination reaction

Palladium(0)-catalyzed Sonogashira cross-coupling reaction of 2-fluoroalkylated (Z)-2-fluoro-1-iodoethene, which is easily prepared from commercially available polyfluorinated alcohols in facile three steps, with terminal alkynes in DMF at room temperature for 24 h took place stereospecifically to give the corresponding 1-fluoroalkylated (Z)-1-fluorobut-1-en-3-yne derivatives in good to excellent yield. Thus obtained fluoroalkylated 1-fluoroenynes were effectively subjected to addition-elimination reaction with various alkynyllithiums at room temperature, leading to 3-fluoroalkylated hex-3-ene-1,5-diyne derivatives in good to high yields with an excellent E selectivity.

2-AMINO PYRIMIDINE COMPOUNDS AS POTENT HSP-90 INHIBITORS

The present invention is directed to compounds of formula (I), or pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.

Ionic liquids on the basis of 2,3,4,6,7,8,9,10-octahydropyrimido-[1,2-a] azepine (1,8-diazabicyclo[5.4.0]undec-7-ene)

New ionic liquids containing alkyl and polyfluoroalkyl substituents and various anions were synthesized from 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a] azepinium ion (1,8-diazabicyclo[5.4.0]undec-7-en-8-ium). Their NMR spectra and miscibility with water and organic solvents were studied. Pleiades Publishing, Inc., 2006.

Facile syntheses of various per- or polyfluoroalkylated internal acetylene derivatives

Treatment of per- or polyfluoroalkylated vinyl iodides 5 with 2equiv. of n-BuLi in THF produced the corresponding lithium acetylides in situ, which were transformed into zinc acetylides by the addition of ZnCl2· TMEDA complex into the reaction mixture. The in situ generated zinc acetylides were exposed to the cross-coupling conditions such as ArI/cat. Pd(PPh 3)4, reflux, 6-12 h, giving rise to the desired per- or polyfluoroalkylated acetylenes in high yields. In the case of trifluoromethylated acetylene, commercially available 2-bromo-3,3,3-trifluoropropene 6 could also be used instead of 5 as the starting material. In the acetylenes having a fluoroalkyl group and an aliphatic side chain, vinyl iodides 7, prepared by radical addition of perfluoroalkyl iodide to terminal acetylenes, were treated with t-BuOK at room temperature or at the reflux temperature of benzene, affording the desired compounds in good yields.