799293-85-9

Basic information

• Product Name: 3-bromothieno[3,2-c]pyridin-4-amine
• Synonyms: 3-bromothieno[3,2-c]pyridin-4-amine;3-BroMo-4-aMinothieno[3,2-c]pyridine;4-AMino-3-broMothieno[3,2...;Thieno[3,2-c]pyridin-4-aMine, 3-broMo-
• CAS NO: 799293-85-9
• Molecular Formula: C₇H₅BrN₂S
• Molecular Weight: 229
• Mol File: 799293-85-9.mol

Chemical Properties

• Melting Point: 157-160 °C
• Boiling Point: 396.9±37.0 °C(Predicted)
• Appearance: /
• Density: 1.836±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 5.59±0.40(Predicted)
• CAS DataBase Reference: 3-bromothieno[3,2-c]pyridin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromothieno[3,2-c]pyridin-4-amine(799293-85-9)
• EPA Substance Registry System: 3-bromothieno[3,2-c]pyridin-4-amine(799293-85-9)

Safety Data

• Hazardous Substances Data: 799293-85-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-Bromothieno[3,2-c]pyridin-4-amine is used as a key intermediate in the synthesis of a wide range of organic compounds, including pharmaceuticals, agrochemicals, and advanced materials. Its versatile structure allows for further functionalization and modification, enabling the development of new molecules with tailored properties and applications.
Used in Organic Electroluminescent Devices:
3-Bromothieno[3,2-c]pyridin-4-amine is used as a precursor in the preparation of organic compounds for organic electroluminescent (OLED) devices. These devices are widely used in display technologies, lighting, and other optoelectronic applications due to their high efficiency, low power consumption, and potential for flexible and transparent designs. The incorporation of 3-bromothieno[3,2-c]pyridin-4-amine into the molecular structure of OLED materials can enhance their performance, stability, and color tunability.

Upstream product

• 799293-83-7 3-bromothieno[3,2-c]pyridin-4(5H)-one 
• 123-91-1 1,4-dioxane 
• 29064-82-2 3-bromo-4-chloro-[3,2-c]-thienopyridine 
• 103686-16-4 trans-3-(4-bromothiophen-2-yl)propenoic acid 
• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 799293-81-5 trans-3-(4-bromothiophen-2-yl)-acryloyl azide 
• 799293-83-7 3-bromo-4-hydroxy-[3,2-c]-thienopyridine 

Downstream Products

• 832695-09-7 3-(4-aminophenyl)-7-iodothieno[3,2-c]pyridin-4-amine 
• 832695-08-6 tert-butyl 4-(4-amino-7-iodothieno[3,2-c]pyridin-3-yl)phenylcarbamate 
• 799293-87-1 4-amino-7-bromo-3-(3-chloro-4-fluorophenyl)-thieno[3,2-c]pyridine 

Relevant articles and documents

N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS

The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

Improved synthesis of 3-substituted-4-amino-[3,2-c]-thienopyridines

(Chemical Equation Presented) Two syntheses of 3-substituted-4-amino-[3,2- c]thienopyridines have been developed to replace the standard literature route to these compounds, which uses unattractive conditions involving azide and high temperatures. The fir

Inhibitors of protein kinases

Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

A novel class of 3,7-diphenyl-4-amino-thieno and furo[3,2-c]pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and potent inhibitors against angiogenetic targets, VEGFR2, Tie-2, and EphB4, have been successfully discovered.

Thienopyridine urea inhibitors of KDR kinase

A series of substituted thienopyridine ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 2, are potent inhibitors of KDR (10 nM) in both enzymatic and cellular assays. Further

Discovery of thienopyridines as Src-family selective Lck inhibitors

We describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed based on a desire to access the unique residues in the extended hinge region of Lck.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Thienopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for treating and preventing tumors ans cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.