825620-25-5Relevant articles and documents
Method for preparing quinolones compound by using pentacarbonyl iron as CO release source
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Paragraph 0012; 0015; 0056; 0058; 0059, (2018/10/19)
The invention discloses a method for preparing quinolones compound by using pentacarbonyl iron as a CO release source. In this method, iron pentacarbonyl is used as a CO release source, and palladiumacetate is used as a catalyst, potassium phosphate and piperazine are used as a base, and acetonitrile is used as a solvent to couple a 2-iodoaniline compound with a terminal alkyne under mild conditions to obtain the quinolones compound. The preparation method has the advantages of simple operation, mild reaction conditions, less catalyst use, less CO release source use, low toxicity, lower cost,wide substrate applicability, and high target compound yield, and the method can be widely used for the preparation of natural quinolones compound.
2-aryl-4-quinolone derivative as well as preparation method and application thereof
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Paragraph 0054-0060, (2018/10/19)
The invention discloses a 2-aryl-4-quinolone derivative as well as a preparation method and an application thereof. The 2-aryl-4-quinolone derivative has the structure shown in formula (I) in the description, wherein R1 is independently selected from one or more of H, C1-C5 alkyl, halogen or C1-C5 alkoxy, and R2 is independently selected from one or more of H, C1-C5 alkyl, CF3, halogen or C1-C5 alkoxy. Test results show that the 2-aryl-4-quinolone derivative has good antibacterial activity and can be used as an antibacterial agent.
Carbonylative Sonogashira annulation sequence: One-pot synthesis of 4-quinolone and 4H-chromen-4-one derivatives
Ghosh, Prasanjit,Nandi, Aritra Kumar,Das, Sajal
, p. 2025 - 2029 (2018/04/25)
Carbonylative Sonogashira annulation sequence for one pot synthesis of 4-quinolone and 4H-chromen-4-one has been developed in presence of Pd-NHC catalyst. Substituted 2-iodoaniline and 2-iodophenol independently underwent in the carbonylative Sonogashira
From Ketones, Amines, and Carbon Monoxide to 4-Quinolones: Palladium-Catalyzed Oxidative Carbonylation
Wu, Jiwei,Zhou, Yuchen,Wu, Ting,Zhou, Yi,Chiang, Chien-Wei,Lei, Aiwen
supporting information, p. 6432 - 6435 (2017/12/08)
A novel method of palladium-catalyzed oxidative carbonylation of ketones, amines, and carbon monoxide for the synthesis of 4-quinolones has been developed. This protocol provides a straightforward route to construct useful 4-quinolone derivatives from ine
Transition-metal-free oxidative intermolecular cyclization reaction: Synthesis of 2-aryl-4-quinolones
Ma, Haojie,Guo, Cui,Zhan, Zhenzhen,Lu, Guoqiang,Zhang, Yixin,Luo, Xinliang,Cui, Xinfeng,Huang, Guosheng
supporting information, p. 5280 - 5283 (2017/07/10)
Herein, a novel and efficient intermolecular cyclization of 2-aminoacetophenones with aldehydes was developed for the synthesis of 2-aryl-4-quinolones through C-C and C-N bond formation. Mild conditions, good functional group tolerance, and substrates without prefunctionalization make this protocol practical, and this strategy will stimulate keen interest in fields of chemistry and biology.
Sequential Cu-catalyzed amidation-base-mediated camps cyclization: A two-step synthesis of 2-aryl-4-quinolones from o-halophenones
Jones, Carrie P.,Anderson, Kevin W.,Buchwald, Stephen L.
, p. 7968 - 7973 (2008/02/13)
(Chemical Equation Presented) A direct two-step method for the preparation of 2-aryl- and 2-vinyl-4-quinolones that utilizes a copper-catalyzed amidation of o-halophenones followed by a base-promoted Camps cyclization of the resulting N-(2-ketoaryl)amides is described. With CuI, a diamine ligand, and base as the catalyst system, the amidation reactions proceed in good yields for a range of aryl, heteroaryl, and vinyl amides. The subsequent Camps cyclization efficiently provides the desired 4-quinolones with the conditions that are described.
A systematic approach to the optimization of substrate-based inhibitors of the hepatitis C virus NS3 protease: Discovery of potent and specific tripeptide inhibitors
Llinàs-Brunet, Montse,Bailey, Murray D.,Ghiro, Elise,Gorys, Vida,Halmos, Ted,Poirier, Martin,Rancourt, Jean,Goudreau, Nathalie
, p. 6584 - 6594 (2007/10/03)
The inadequate efficacy and tolerability of current therapies for the infectious liver disease caused by the hepatitis C virus have warranted significant efforts in the development of new therapeutics. We have previously reported competitive peptide inhib
Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: Identification as antimitotic agents interacting with tubulin
Kuo,Lee,Juang,Lin,Wu,Chang,Lednicer,Paull,Lin,Hamel,Lee
, p. 1146 - 1156 (2007/10/02)
A series of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds have been synthesized and evaluated as cytotoxic compounds and as antimitotic agents interacting with tubulin. The 2-phenyl-4-quinolones (22-30) with substituents
