85064-61-5

Basic information

• Product Name: Tetrahydropyranyl-4-acetic acid
• Synonyms: 2-(TETRAHYDRO-2H-PYRAN-4-YL)ACETIC ACID;(TETRAHYDRO-PYRAN-4-YL)-ACETIC ACID;TETRAHYDROPYRANYL-4-ACETIC ACID;TETRAHYDRO-2H-PYRAN-4-YLACETIC ACID;Tetrahydro-2H-pyran-4-ylacetic acid 97%;Tetrahydropyran-4-acetic acid;Tetrahydro-4-pyranacetic acid;Tetrahydropyran-4-acetic acid ,97%
• CAS NO: 85064-61-5
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.16838
• EINECS: 210-361-8
• Product Categories: blocks;Carboxes;Heterocycles;Heterocycles series;Carboxylic Acids;Pyrans, Piperidines &Piperazines;Carboxylic Acids;Pyrans, Piperidines & Piperazines
• Mol File: 85064-61-5.mol

Chemical Properties

• Melting Point: 48-50°C
• Boiling Point: 285.1 °C at 760 mmHg
• Flash Point: 119.2 °C
• Appearance: white to light yellow crystal powder
• Density: 1.111 g/cm³
• Vapor Pressure: 0.000738mmHg at 25°C
• Storage Temp.: Keep Cold
• PKA: 4.60±0.10(Predicted)
• CAS DataBase Reference: Tetrahydropyranyl-4-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydropyranyl-4-acetic acid(85064-61-5)
• EPA Substance Registry System: Tetrahydropyranyl-4-acetic acid(85064-61-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36/37/39-22-39
• RIDADR: 1759
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 85064-61-5(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C7H12O3/c8-7(9)5-6-1-3-10-4-2-6/h6H,1-5H2,(H,8,9)/p-1

Upstream product

• 850429-50-4 2-(tetrahydro-2H-pyran-4-yl)acetonitrile 
• 14390-06-8 tetrahydropyran-4-yl-malonic acid 
• 103260-44-2 ethyl tetrahydropyran-4-acetate 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 138302-49-5 methyl 2-(dihydro-2H-pyran-4-(3H)-ylidene)acetate 
• 156002-64-1 methyl 2-(tetrahydro-2H-pyran-4-yl)acetate 
• 854697-63-5 tetrahydropyran-4-yl-malonic acid diethyl ester 
• 125552-89-8 4-(bromomethyl)tetrahydro-2H-pyran 
• 14774-37-9 (tetrahydro-2H-pyran-4-yl)methanol 
• 2081-44-9 Tetrahydro-pyran-4-ol 
• 130312-00-4 ethyl tetrahydro-4H-pyran-4-ylideneacetate 

Downstream Products

• 815618-35-0 (R)-4-benzyl-3-(2-(tetrahydro-2H-pyran-4-yl)acetyl)oxazolidin-2-one 
• 1420039-48-0 benzyl 2-hydroxy-2-(tetrahydro-2H-pyran-4-yl)acetate 
• 1420039-50-4 benzyl 2-oxo-2-(tetrahydro-2H-pyran-4-yl)acetate 
• 1420039-52-6 dibenzyl 2-hydroxy-2,3-bis(tetrahydro-2H-pyran-4-yl)succinate 
• 929556-48-9 benzyl 2-(tetrahydro-2H-pyran-4-yl)acetate 

Relevant articles and documents

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Hepatitis C Virus Inhibitors

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Synthesis and activity of putative small-molecule inhibitors of the F-box protein SKP2

The tetrahydropyran 4-(((3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline was reported to disrupt the SCFSKP2 E3 ligase complex. Efficient syntheses of this tetrahydropyran derivative and analogues, including the des-dimethyl derivative 4-(((3-(tetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline, are described. The enantiomers of the des-dimethyl compound were obtained using Evans' chiral auxiliaries. Structure-activity relationships for these tetrahydropyrans and analogues have been determined by measurement of growth-inhibitory activities in HeLa cells, which indicated a non-specific mechanism of action that correlates with inhibitor lipophilicity. However, preliminary data with (R)-and (S)-4-(((3-(tetrahydro-2H-pyran-4-yl)-4-phenylbutyl)amino)methyl)-N,N-dimethylaniline showed enantioselective inhibition of the degradation of p27 in a cell-based assay that acts as a reporter of SKP2 activity.

NDM INHIBITOR

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BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDINE DERIVATIVES USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE

Novel compounds of formula (1.0) are disclosed. In Formula (1.0) a represents N or NO, R and R are halo, R and R are independently H or halo provided that at least one is H, X is C, CH or N, and T represents a five or six membered heterocycloalkyl ring having one or two heteroatoms selected from S or O. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.

HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS

A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS

A class of piperazine and related heterocyclic derivatives, substituted at the 4-position by a substituted aryl or heteroaryl moiety, and at the 1-position by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

Compounds useful for inhibition of farnesyl protein transferase

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Potent HIV Protease Inhibitors: The Development of Tetrahydrofuranylglycines as Novel P2 Ligands and Pyrazine Amides as P3-Ligands

A series of protease inhibitors bearing constrained unnaturel amino acids at the P2-position and novel heterocycles at the P3-position of compound 1 (Ro 31-8959) were synthesized, and their in vitro enzyme inhibitory and antiviral ac

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A triazolo-1,4-di-azepine compound of the below given formulas and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. STR1 in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is--OCO--,--NHCO--,--CO--or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.