860296-24-8

Basic information

• Product Name: 6-Chloro-5-fluoro-pyridine-2-carboxylic acid
• Synonyms: 6-Chloro-5-fluoro-pyridine-2-carboxylic acid;6-Chloro-5-fluoropicolinic acid;6-Chloro-5-fluoropyridine-2-carboxylic acid AldrichCPR;2-Chloro-3-fluoro-6-carboxypyridine
• CAS NO: 860296-24-8
• Molecular Formula: C₆H₃ClFNO₂
• Molecular Weight: 175.5449232
• Mol File: 860296-24-8.mol

Chemical Properties

• Melting Point: 193-195 °C(Solv: heptane (142-82-5))
• Boiling Point: 310.3±37.0 °C(Predicted)
• Appearance: Off-white/Solid
• Density: 1.576±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.21±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 6-Chloro-5-fluoro-pyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-fluoro-pyridine-2-carboxylic acid(860296-24-8)
• EPA Substance Registry System: 6-Chloro-5-fluoro-pyridine-2-carboxylic acid(860296-24-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 860296-24-8(Hazardous Substances Data)

Usage

Uses

It is an important intermediate for pharmaceutical.

Upstream product

• 372-47-4 3-Fluoropyridine 
• 77332-77-5 3-fluoro-4-(trimethylsilyl)pyridine 
• 107504-07-4 5-fluoro-pyridine-2-carboxylic acid methyl ester 
• 1346555-30-3 5-fluoro-2-(methoxycarbonyl)pyridine-1-oxide 
• 1214337-05-9 6-chloro-5-fluoro-2-picolinic acid methyl ester 
• 107504-08-5 5-fluoropicolinic acid 
• 860296-22-6 2-chloro-3-fluoro-4-(trimethylsilyl)pyridine 
• 860296-23-7 6-chloro-5-fluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid 

Downstream Products

• 107504-08-5 5-fluoropicolinic acid 
• 1375798-66-5 6-chloro-5-fluoropyridine-2-carboxylic acid (2-carbamoylphenyl)amide 
• 1375296-36-8 2-(5-fluoro-6-methylpyridin-2-yl)-4-phenylquinazoline 

Relevant articles and documents

NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo[l,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[l,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8- substituted imidazo[l,5-a]pyridines that can be useful for inhibiting indoleamine 2,3- dioxygenase and/or tryptophane 2,3-dioxygenase and for treating diseases or disorders mediated thereby.

PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME

Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11β-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11β-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human- derived 11β-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LAD A), insulin tolerance syndromes, obesity, impaired glucose tolerane (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.

Converting core compounds into building blocks: The concept of regiochemically exhaustive functionalization

In a model study, 3-fluorophenol and 3-fluoropyridine were converted into the each time four possible carboxylic acids by passing through the corresponding organometallic intermediates. As an attempt to generalize the findings reveals, a restricted set of principles and methods suffices to cope with all standard scenarios. The most valuable and versatile tools for the regiochemically exhaustive functionalization of a great variety of substrate patterns are the optionally site-selective metalation (either by reagent/substrate matching or by peripheral coordination control), the use of activating or congesting protective groups and the basicity gradient-driven heavy halogen migration (followed by halogen/metal permutation). Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.