865304-71-8

Basic information

• Product Name: 5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine
• Synonyms: EOS-61050
• CAS NO: 865304-71-8
• Molecular Formula: C₁₄H₁₈N₄O₂
• Molecular Weight: 274.31832
• Mol File: 865304-71-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine(865304-71-8)
• EPA Substance Registry System: 5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine(865304-71-8)

Safety Data

• Hazardous Substances Data: 865304-71-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological activities and unique structural features.
Used in Agrochemical Development:
In the agrochemical industry, 5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine is utilized as a precursor in the development of new agrochemicals, leveraging its chemical properties to enhance crop protection and yield.
Used in Drug Discovery and Development:
5-(2-isopropyl-4-Methoxy-phenoxy)-pyriMidine-2,4-diaMine is employed as a compound of interest in drug discovery and development due to its potential biological activities, which may contribute to the creation of novel therapeutic agents.
Further studies are necessary to fully understand the properties and potential uses of this chemical compound, as its applications may extend beyond the current understanding in various industries.

Upstream product

• 927887-20-5 2-(2-isopropyl-4-methoxyphenoxy)-3-phenylaminoacrylonitrile 
• 593-85-1 diguanidine carbonate 
• 1145716-61-5 C₁₄H₁₇NO₃ 
• 927872-64-8 2-(2-isopropyl-4-methoxyphenoxy)acetonitrile 
• 50-01-1 guanidine hydrochloride 
• 109-94-4 formic acid ethyl ester 
• 13522-86-6 2-iso-propyl-4-methoxyphenol 
• 1004-01-9 5-bromopyrimidine-2,4-diamine 
• 4761-93-7 imidodicarbonimidic diamide hydrochloride 

Downstream Products

• 865304-28-5 1-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]-ethanone 
• 865305-30-2 [3H]-AF-353 
• 865305-61-9 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonyl chloride 
• 865304-43-4 2-[5-(2,4-diaminopyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]-propan-2-ol 
• 865304-45-6 1-[5-(2,4-diamino-pyrimidine-5-yloxy)-4-isopropyl-2-methoxy-phenyl]-ethanol 
• 865305-75-5 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-thiobenzamide 
• 865305-31-3 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzonitrile 
• 865304-65-0 4-(2,4-diamino-pyrimidin-5-yloxy)-2-iodo-5-isopropyl-phenol 

Relevant articles and documents

Development of a green and sustainable manufacturing process for gefapixant citrate (MK-7264) Part 3: Development of a one-pot formylation-cyclization sequence to the diaminopyrimidine core

The development of a safe, robust, and efficient manufacturing route for the synthesis of diaminopyrimidine 1, a key intermediate to gefapixant citrate (MK-7264), is described. A full mechanistic understanding of the cyclization step in the presence of guanidine was established by performing isotopic labeling experiments and identification of impurities. Guided by the mechanistic understanding, further attempts to modify the cyclization reaction by employing additives to reduce the triazine (9) formation and guanidine loading will also be presented. This newly developed method delivered compound 1 in 88-94% yield on a commercial scale and addressed the shortcomings of the early synthetic route including high PMI, low atom economy, long cycle-time, and multiple purifications to achieve the desired quality.

Preparation method of amine compound

The invention relates to a preparation method of an amine compound, and belongs to the field of medicinal chemistry. According to the preparation method, 2-isopropyl-4-methoxyphenol is used as a starting material, and the amine compound can be obtained th

NOVEL PROCESS FOR SYNTHESIS OF A PHENOXY DIAMINOPYRIMIDINE COMPOUND

Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-isopropyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one emb

Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X3/P2X2/3 antagonist for the treatment of pain

P2X purinoceptors are ligand-gated ion channels whose endogenous ligand is ATP. Both the P2X3 and P2X2/3 receptor subtypes have been shown to play an important role in the regulation of sensory function and dual P2X3/P2X2/3 antagonists offer significant potential for the treatment of pain. A high-throughput screen of the Roche compound collection resulted in the identification of a novel series of diaminopyrimidines; subsequent optimization resulted in the discovery of RO-4, a potent, selective and drug-like dual P2X3/P2X2/3 antagonist.

Diaminopyrimidines as P2X3 and P2X2/3 modulators

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the compounds being of formula (I): wherein R1, R2, R3 and R4 are as defined herein.

Diaminopyrimidines as P2X3 and P2X2/3 modulators

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, Rs

Process for synthesis of phenoxy diaminopyrimidine derivatives

A method for preparing a compound of formula I the method comprising treating a compound of formula d with an iodination reagent, to form the compound of formula I, wherein R1, R2 and R3 are as defined herein.

Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases

Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Diaminopyrimidines as P2X3 and P2X2/3 antagonists

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.