877997-98-3

Basic information

• Product Name: PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE
• Synonyms: Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester (for Acotiamide);Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester;Ethyl 2-(2-hydroxy-4,5-diMethoxybenzaMido)thiazole-4-carboxylate;PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE;2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester;Phenyl 2-hydroxy-4,5-dimethoxybenzoate Benzoic acid,2-hydroxy-4,5-dimethoxy-,phenyl ester (for Acotiamide)
• CAS NO: 877997-98-3
• Molecular Formula: C₁₅H₁₄O₅
• Molecular Weight: 274.27
• EINECS: 1806241-263-5
• Mol File: 877997-98-3.mol

Chemical Properties

• Boiling Point: 431.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.250±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.83±0.23(Predicted)
• CAS DataBase Reference: PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE(877997-98-3)
• EPA Substance Registry System: PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE(877997-98-3)

Safety Data

• Hazardous Substances Data: 877997-98-3(Hazardous Substances Data)

Usage

Uses

Used in Cosmetic and Personal Care Industry:
PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE is used as a fragrance ingredient and a component in the formulation of cosmetic and personal care products, leveraging its antioxidant and anti-inflammatory properties to enhance product efficacy and safety.
Used in Food and Beverage Industry:
In the food and beverage sector, PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE serves as a flavoring agent, contributing to the taste and aroma profiles of various products while also potentially offering health benefits due to its antioxidant properties.
Used in Sunscreen Products:
PHENYL 2-HYDROXY-4,5-DIMETHOXYBENZOATE is utilized as a UV filter in sunscreen products, providing protection against harmful ultraviolet radiation and helping to prevent skin damage.

Upstream product

• 101-02-0 triphenyl phosphite 
• 5722-93-0 2-hydroxy-4,5-dimethoxybenzoic acid 
• 108-95-2 phenol 
• 93-07-2 Veratric acid 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 
• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 

Downstream Products

• 877997-99-4 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester 
• 877998-00-0 CH₄O*C₁₄H₁₄N₂O₆S 
• 185104-11-4 2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride 
• 185106-16-5 Acotiamide 

Relevant articles and documents

arab League tests for the amine and a method for the preparation of its hydrochloride (by machine translation)

The invention discloses a arab League tests for the amine method for preparing and its hydrochloride, 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxylic acid methyl ester, and N, N-diisopropyl ethylenediamin in the molten state after reaction under N-[ 2 - (diisopropyl amino) ethyl] - 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxamide, hydrochloric acid for hydrochloric acid prepared by adding dropwisely added methanol trihydrate arab League takes a test for somebody else the amine, the technical proposal of the present invention reduces the use of toluene, economic and convenient, the reaction is complete, process safety; reduced at the same time the residual toluene in the final product, and impurity 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 4-carboxyl -1, the content of 3-thiazole, the product quality is promoted; and is easy to be refined and purification of the crude product, the reaction yield is high. (by machine translation)

METHOD FOR PRODUCING 2-BROMO-4,5-DIALKOXY BENZOIC ACID

Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material. A method for producing a 2-bromo-4,5-dialkoxybenzoic acid represented by the following formula (2): (wherein each of R1 and R2 represents a lower alkyl group), the method including causing a 3,4-dialkoxybenzoic acid represented by the following formula (1): (wherein R1 and R2 have the same meanings as defined above) to react with bromine in concentrated hydrochloric acid.

METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE

Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.

METHOD FOR PRODUCING AMINOTHIAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE

Disclosed is a selective demethylation process of a 2-methoxy group. Specifically disclosed is a method for producing a compound represented by the formula (7) below through the following reactions.