Welcome to LookChem.com Sign In|Join Free

CAS

  • or
5-BROMO-2-PHENYLOXAZOLE is a chemical compound characterized by the presence of a bromine atom at the 5th position and a phenyl group at the 2nd position of the oxazole ring. It is a heterocyclic compound with potential applications in various fields.

92629-11-3 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 92629-11-3 Structure
  • Basic information

    1. Product Name: 5-BROMO-2-PHENYLOXAZOLE
    2. Synonyms: 5-BROMO-2-PHENYLOXAZOLE;5-broMo-2-phenyl-1,3-oxazole
    3. CAS NO:92629-11-3
    4. Molecular Formula: C9H6BrNO
    5. Molecular Weight: 224.05404
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 92629-11-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 308.3 °C at 760 mmHg
    3. Flash Point: 140.2 °C
    4. Appearance: /
    5. Density: 1.524±0.06 g/cm3 (20 ºC 760 Torr)
    6. Vapor Pressure: 0.00125mmHg at 25°C
    7. Refractive Index: 1.58
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. PKA: -0.56±0.10(Predicted)
    11. CAS DataBase Reference: 5-BROMO-2-PHENYLOXAZOLE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 5-BROMO-2-PHENYLOXAZOLE(92629-11-3)
    13. EPA Substance Registry System: 5-BROMO-2-PHENYLOXAZOLE(92629-11-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 92629-11-3(Hazardous Substances Data)

92629-11-3 Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-2-PHENYLOXAZOLE is used as a Δ5-desaturase inhibitor for the preparation of heterocyclic compounds. This application is significant in the development of pharmaceuticals, as Δ5-desaturase enzymes play a crucial role in the biosynthesis of certain fatty acids and other lipids, which are involved in various physiological processes and diseases.
In the preparation of heterocyclic compounds, 5-BROMO-2-PHENYLOXAZOLE serves as a key intermediate, enabling the synthesis of novel compounds with potential therapeutic properties. By inhibiting the Δ5-desaturase enzyme, these heterocyclic compounds can modulate lipid metabolism and potentially offer treatment options for various health conditions related to lipid imbalances.

Check Digit Verification of cas no

The CAS Registry Mumber 92629-11-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,6,2 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 92629-11:
(7*9)+(6*2)+(5*6)+(4*2)+(3*9)+(2*1)+(1*1)=143
143 % 10 = 3
So 92629-11-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H6BrNO/c10-8-6-11-9(12-8)7-4-2-1-3-5-7/h1-6H

92629-11-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromo-2-phenyl-1,3-oxazole

1.2 Other means of identification

Product number -
Other names 5-bromo-2-phenyloxazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:92629-11-3 SDS

92629-11-3Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS DELTA-5 DESATURASE INHIBITORS AND METHODS OF USE

-

Page/Page column 97, (2021/06/04)

The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase ("D5D"). The compounds have a general Formula (I): wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

Composite tetraheteroarylenes and related higher cyclic oligomers of heteroarenes produced by palladium-catalyzed direct coupling

Fukuzumi, Keita,Nishii, Yu Ji,Miura, Masahiro

, p. 2030 - 2037 (2019/12/23)

Substantial research interests have been focused on cyclic π-conjugated molecules owing to their unique chemical and physical properties. By constructing hybrid aromatic arrays within these cyclic systems, new series of composite macrocycles would be prov

Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks

Solomin, Vitalii V.,Radchenko, Dmytro S.,Slobodyanyuk, Evgeniy Y.,Geraschenko, Oleksandr V.,Vashchenko, Bohdan V.,Grygorenko, Oleksandr O.

, p. 2884 - 2898 (2019/03/07)

An approach to synthesis of 2-, 4-, and 5-bromooxazoles is described. The method was optimized, and its scope was extended to all three isomeric parents, as well as various alkyl- and aryl-substituted bromooxazoles. It was found that direct regiocontrolled lithiation followed by reaction with electrophilic bromine source was common for all substrates and led exclusively to the target substituted 2-, 4- and 5-bromooxazoles on multigram scale. The utility of the multipurpose building blocks obtained in this work was demonstrated in the Suzuki–Miyaura cross-coupling reaction under parallel synthesis conditions.

Versatile Photochemical Reactivity of Diverse Substituted 2-, 4- and 5-(o-Vinylstyryl)oxazoles

?agud, Ivana,?indler-Kulyk, Marija,Vojnovi?-Jandri?, Dragana,Marini?, ?eljko

, p. 515 - 524 (2018/02/09)

To study the effects of the position of the hexatrienyl moiety on the oxazole ring, novel substituted cis/trans-2/4/5-(2-vinylstyryl)oxazoles have been synthesized. These novel compounds were prepared by Wittig reaction from the diphosphonium salt of α,α′-o-xylenedibromide, formaldehyde and the corresponding 2-methyl-4-, 4-methyl-2-, 2-pheny-5- and 4-methyl-5-oxazolecarbaldehyde, respectively. Aldehydes were synthesized by using several synthetic approaches. By applying intramolecular photocycloaddition, 2-methyl-4-(2-vinylstyryl)oxazole afforded, as major product, fused oxazoline-benzobicyclo[3.2.1]octene with small quantities of 4-(1,2-dihydronaphthalen-2-yl)-2-methyloxazole, as electrocyclization product. Upon irradiation of 4-methyl-5-(2-vinylstyryl)oxazole, endo- and exo-benzobicyclo[2.1.1]hexene products were formed by [2+2] cycloaddition; this was the first instance of the 1,4-closure to the bicyclo[2.1.1]hexene skeleton in the 2-, 4-, and 5-oxazole-stilbene derivatives studied so far. Derivatives 2-phenyl-5- and 4-methyl-2-(2-vinylstyryl)oxazole did not react and gave only high-weight molecular products but were crucial as a comparison in the overall mechanistic study. We have found that, depending on the position of the hexatrienyl moiety in the oxazole ring, as well as on the position of the methyl/phenyl substituents, these new vinylstyryl-2/4/5-oxazole derivatives show diverse photochemical behavior.

Synthesis of 2-Aryl- and 5-Alkyl-2-aryloxazoles from 2-Aryl-5-bromooxazoles

Kashima, Choji,Arao, Hideki

, p. 873 - 874 (2007/10/02)

2-Aryloxazoles, their 5-deuterio derivatives, and 5-alkyl-2-aryloxazoles are prepared in good yields from 2-aryl-5-bromooxazoles via halogen/metal exchange with butyllithium followed by treatment with water, methanol-O-d, or alkyl halides, respectively.

SYNTHESIS AND SOME ELECTROPHILIC SUBSTITUTION REACTIONS OF 2-PHENYLOXAZOLE

Belen'kii, L. I.,Cheskis, M. A.

, p. 713 - 716 (2007/10/02)

A new synthesis of 2-phenyloxazole that includes the preparation of 2-phenyloxazoline and aromatization of the latter by the action of nickel peroxide was developed.It was established that under conditions that exclude protonation electrophilic substituti

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 92629-11-3