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Cas Database

100-03-8

100-03-8

Identification

Synonyms:Benzenesulfinicacid, p-chloro- (6CI,7CI,8CI);4-Chlorobenzenesulfinic acid;p-Chlorobenzenesulfinic acid;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 29 Articles be found

-

Kobayashi,M.,Koga,N.

, p. 1788 - 1791 (1966)

-

Reduction of Sulfonic Acids and Related Organosulfur Compounds with Triphenylphosphine-Iodine System

Oae, Shigeru,Togo, Hideo

, p. 3802 - 3812 (1983)

Arenesulfonic acids, their sodium salts, and alkyl arenesulfonates can be reduced readily to the corresponding arenethiols quantitatively by treatment with a mixture of triphenylphosphine and a catalytic amount of iodine, while alkanesulfonic acids, sulfinic acids, disulfides, thiosulfonic S-esters, and sulfonates are also readily reduced to the corresponding thiols similarly.Upon treatment with a mixture of triphenylphosphine and excess iodine, however, these aliphatic sulfur compounds are converted eventually to the corresponding alkyl iodides.The relative reactivities of these sulfonyl derivatives in the reaction with the triphenylphosphine-iodine system are the following.Aromatic series: ArSO2Cl, ArSO2SAr' > ArSO2H > ArSO3R > ArSO3-HNBu3+ (or PyH+) > ArSO3H > ArSO2SO2Ar >> ArSO2CH2C(CH3)3, ArSO3Ar'.Aliphatic series: RSO2Cl, RSO2SR', RSO2-HNBu3+ > RSO3-HNBu3+ > RSSR, RSO2H > RSO3H > RSH > RSO3R'.In these reactions, the arenesulfonic acids bearing electron-donating substituents can be reduced more readily than those having electron-withdrawing substituents.

γ-Oxosulfones as inhibitors of aldehyde dehydrogenase

Messinger,Borchert Bremer

, p. 663 - 667 (1983)

-

tert-Butyl Hydroperoxide-Initiated Radical Cyclization of 1-(Allyloxy)-2-(1-Arylvinyl)Benzenes with Sulfinic Acids to Access Sulfonated Benzoxepines

Kuang, Kaimo,Wu, Meixia,Wu, Sixin,Xia, Ziqin,Xu, Qiankun,Zhang, Man,Zhou, Nengneng

supporting information, p. 3491 - 3495 (2021/06/28)

A tert-butyl hydroperoxide-initiated radical cyclization of 1-(allyloxy)-2-(1-arylvinyl)benzenes with sulfinic acids for the construction of sulfonated benzoxepines is developed. This reaction involves a radical pathway and offers a straightforward route to the formation of seven-membered ring via sulfonylation/cyclization process. This methodology features mild reaction conditions, a broad substrate scope and good functional group tolerance. (Figure presented.).

Synergistic combination of visible-light photo-catalytic electron and energy transfer facilitating multicomponent synthesis of β-functionalized α,α-diarylethylamines

Wu, Yanan,Zhang, Yipin,Jiang, Mingjie,Dong, Xunqing,Jalani, Hitesh B.,Li, Guigen,Lu, Hongjian

, p. 6405 - 6408 (2019/06/07)

A synthetic strategy with the visible-light photo-catalytic synergistic combination of electron and energy transfer processes has been developed. The mild reaction conditions allow the radical-radical cross-coupling phenomenon for the multicomponent synthesis of β-arylsulfonyl(diarylphosphinoyl)-α,α-diarylethyl-amines from readily available arylsulfinic acids (diarylphosphine oxides), 1,1-diarylethylenes and arylazides.

Process route upstream and downstream products

Process route

4-chloro-benzenethiosulfonic acid <i>S</i>-(2-nitro-phenyl ester)
112071-03-1

4-chloro-benzenethiosulfonic acid S-(2-nitro-phenyl ester)

sodium ethanolate
141-52-6

sodium ethanolate

acetylacetone
123-54-6,81235-32-7

acetylacetone

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

3-(2-nitro-phenylsulfanyl)-pentane-2,4-dione
22805-28-3

3-(2-nitro-phenylsulfanyl)-pentane-2,4-dione

Conditions
Conditions Yield
(4-chloro-benzenesulfonyl)-(2-nitro-phenyl)-disulfane

(4-chloro-benzenesulfonyl)-(2-nitro-phenyl)-disulfane

sodium ethanolate
141-52-6

sodium ethanolate

acetylacetone
123-54-6,81235-32-7

acetylacetone

bis(2-nitrophenyl)disulfide
1155-00-6

bis(2-nitrophenyl)disulfide

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

3-(2-nitro-phenylsulfanyl)-pentane-2,4-dione
22805-28-3

3-(2-nitro-phenylsulfanyl)-pentane-2,4-dione

Conditions
Conditions Yield
4-chloro-aniline
106-47-8

4-chloro-aniline

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

Conditions
Conditions Yield
Multistep reaction; (i) NaNO2, aq. HCl, (ii) SO2;
p-toluene sulfinic acid
536-57-2

p-toluene sulfinic acid

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

Conditions
Conditions Yield
With chloro-trimethyl-silane; In chloroform; for 0.5h; Yield given; Ambient temperature;
3-methyl-2-phenylpyrrocoline
6028-82-6

3-methyl-2-phenylpyrrocoline

phenyl 4-chlorobenzenethiosulfonate
1142-97-8

phenyl 4-chlorobenzenethiosulfonate

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

3-methyl-2-phenyl-1-(phenylthio)indolizine

3-methyl-2-phenyl-1-(phenylthio)indolizine

Conditions
Conditions Yield
In dichloromethane; for 48h; Ambient temperature;
88%
1-methyl-2-phenylindolizine
1019-12-1

1-methyl-2-phenylindolizine

phenyl 4-chlorobenzenethiosulfonate
1142-97-8

phenyl 4-chlorobenzenethiosulfonate

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

1-methyl-2-phenyl-3-(phenylthio)indolizine

1-methyl-2-phenyl-3-(phenylthio)indolizine

Conditions
Conditions Yield
In dichloromethane; for 40h; Ambient temperature;
92%
1-methyl-2-phenyl-1H-indole
3558-24-5

1-methyl-2-phenyl-1H-indole

phenyl 4-chlorobenzenethiosulfonate
1142-97-8

phenyl 4-chlorobenzenethiosulfonate

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

1-methyl-2-phenyl-3-(phenylthio)-1H-indole
82946-84-7

1-methyl-2-phenyl-3-(phenylthio)-1H-indole

Conditions
Conditions Yield
In dichloromethane; for 48h; Ambient temperature;
60%
1-Phenyl-2-nitroethyl-p-chlorphenylsulfon
42604-93-3

1-Phenyl-2-nitroethyl-p-chlorphenylsulfon

(2-nitroethenyl)benzene
102-96-5

(2-nitroethenyl)benzene

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

Conditions
Conditions Yield
With sodium hydroxide; In acetone; at 20 ℃; Rate constant; Equilibrium constant;
p-chlorophenyl-3-hydroxypropyl-sulfide
5755-58-8

p-chlorophenyl-3-hydroxypropyl-sulfide

4,4'-dichlorodiphenyl disulfide
1142-19-4

4,4'-dichlorodiphenyl disulfide

3-phenylthiopropanol
24536-40-1

3-phenylthiopropanol

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

para-thiocresol
106-45-6

para-thiocresol

Conditions
Conditions Yield
aluminium trichloride; nitromethane; In carbon disulfide; for 40h; Ambient temperature;
2%
8%
40%
40%
4-chlorobenzenesulfonic acid n-hexylester
69564-60-9

4-chlorobenzenesulfonic acid n-hexylester

4-chlorobenzenesulfinic acid
100-03-8

4-chlorobenzenesulfinic acid

hexan-1-ol
111-27-3

hexan-1-ol

Conditions
Conditions Yield
With lithium amalgam; In 1,4-dioxane; isopropyl alcohol; at 23 ℃; for 2h;
95%
91%

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