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3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 100240-53-7 Structure
  • Basic information

    1. Product Name: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine
    2. Synonyms: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine
    3. CAS NO:100240-53-7
    4. Molecular Formula: C14H15ClN4
    5. Molecular Weight: 274.76
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 100240-53-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine(100240-53-7)
    11. EPA Substance Registry System: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine(100240-53-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 100240-53-7(Hazardous Substances Data)

100240-53-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 100240-53-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,2,4 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 100240-53:
(8*1)+(7*0)+(6*0)+(5*2)+(4*4)+(3*0)+(2*5)+(1*3)=47
47 % 10 = 7
So 100240-53-7 is a valid CAS Registry Number.

100240-53-7Relevant articles and documents

Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors

?zdemir, Zeynep,Alag?z, Mehmet Abdullah,Uslu, Harun,Karakurt, Arzu,Erikci, Acelya,Ucar, Gulberk,Uysal, Mehtap

, p. 692 - 704 (2020/03/11)

Background: Since brain neurotransmitter levels are associated with the pathology of various neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) plays a critical role in balancing these neurotransmitters in the brain. MAO isofo

The novel synthesized pyridazinone derivates had the antiproliferative and apoptotic effects in SHSY5Y and HEP3B cancer cell line

?iftci, Osman,?zdemir, Zeynep,Acar, Ceren,S?zen, Mert,Ba?ak-Türkmen, Ne?e,Ayhan, ?dris,G?zükara, Harika

, p. 323 - 331 (2018/04/20)

Background: Brain cancer (neuroblastoma) and liver cancer (hepatocellular carcinoma) are common cancer types among others worldwide which do not have a radical treatment and cure. Objective: In the current study, five novel pyridazinone derivates bearing

Selective mono-amination of dichlorodiazines

Sengmany, Stéphane,Lebre, Julie,Le Gall, Ewan,Léonel, Eric

, p. 4859 - 4867 (2015/08/03)

A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of trieth

An electrochemical nickel-catalyzed arylation of 3-amino-6- chloropyridazines

Sengmany, Stephane,Vitu-Thiebaud, Arnaud,Le Gall, Erwan,Condon, Sylvie,Leonel, Eric,Thobie-Gautier, Christine,Pipelier, Muriel,Lebreton, Jacques,Dubreuil, Didier

, p. 370 - 379 (2013/03/13)

3-Amino-6-aryl- and 3-amino-6-heteroarylpyridazines have been obtained in generally good yield using a nickel-catalyzed electrochemical cross-coupling between 3-amino-6-chloropyridazines and aryl or heteroaryl halides at room temperature. Comparative experiments involving classical palladium-catalyzed reactions, such as Suzuki, Stille, or Negishi cross-couplings, reveal that the electrochemical method can constitute a reliable alternative tool for biaryl formation. A possible reaction mechanism is proposed on the basis of electrochemical analyses.

Synthesis and antimicrobial, acetylcholinesterase and butyrylcholinesterase inhibitory activities of novel ester and hydrazide derivatives of 3(2H)-pyridazinone

Oezcelik, Azime Berna,Goekce, Mehtap,Orhan, Ilkay,Kaynak, Fatma,Sahin, Mustafa Fethi

scheme or table, p. 452 - 458 (2011/04/25)

In the current study, some novel ethyl 6-[(substituted-phenylpiperazine]- 3(2H)-pyridazinone-2-yl propionate III and 6-[(substituted-phenylpiperazine]- 3(2H)-pyridazinone-2-yl propionohydrazide IV derivatives were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The structures of these new pyridazinone derivatives were confirmed by their IR, 1H-NMR spectra and elementary analysis. 6-Substituted-3(2H)- pyridazinone-2-yl propionate IIIa-e derivatives showed significant inhibitory activity against AChE and BChE. 6-[4-(3-Trifluoromethylphenyl)-piperazine]-3(2H) -pyridazinone-2-yl propionate IIIe has been found to be the most active compound in terms of inhibition of either AChE or BChE. Compound IIIe exhibited inhibitory activity close to that of galantamine (CAS 357-70-0) and did not show any selectivity between the two enzymes. Also the antimicrobial activities of III and IV derivatives have been evaluated. All III and IV derivatives exhibited poor antibacterial activities but moderate antifungal activities. ECV ? Editio Cantor Verlag.

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