100240-53-7

Basic information

• Product Name: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine
• Synonyms: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine
• CAS NO: 100240-53-7
• Molecular Formula: C14H15ClN4
• Molecular Weight: 274.76
• Mol File: 100240-53-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine(100240-53-7)
• EPA Substance Registry System: 3-Chloro-6-(4-phenylpiperazin-1-yl)pyridazine(100240-53-7)

Safety Data

• Hazardous Substances Data: 100240-53-7(Hazardous Substances Data)

Upstream product

• 141-30-0 3,6-dichlorpyridazine 
• 92-54-6 4-phenyl-1-piperazine 

Downstream Products

• 1254944-53-0 C₁₉H₂₄N₄O₃ 
• 1254944-58-5 C₁₇H₂₂N₆O₂ 
• 1312719-50-8 6-(4-(phenyl)piperazine-1-yl)-3(2H)-pyridazinone-2-ylacetohydrazide 

Relevant articles and documents

Synthesis, molecular modelling and biological activity of some pyridazinone derivatives as selective human monoamine oxidase-B inhibitors

Background: Since brain neurotransmitter levels are associated with the pathology of various neurodegenerative diseases like Parkinson and Alzheimer, monoamineoxidase (MAO) plays a critical role in balancing these neurotransmitters in the brain. MAO isofo

Selective mono-amination of dichlorodiazines

A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of trieth

Synthesis and antimicrobial, acetylcholinesterase and butyrylcholinesterase inhibitory activities of novel ester and hydrazide derivatives of 3(2H)-pyridazinone

In the current study, some novel ethyl 6-[(substituted-phenylpiperazine]- 3(2H)-pyridazinone-2-yl propionate III and 6-[(substituted-phenylpiperazine]- 3(2H)-pyridazinone-2-yl propionohydrazide IV derivatives were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The structures of these new pyridazinone derivatives were confirmed by their IR, 1H-NMR spectra and elementary analysis. 6-Substituted-3(2H)- pyridazinone-2-yl propionate IIIa-e derivatives showed significant inhibitory activity against AChE and BChE. 6-[4-(3-Trifluoromethylphenyl)-piperazine]-3(2H) -pyridazinone-2-yl propionate IIIe has been found to be the most active compound in terms of inhibition of either AChE or BChE. Compound IIIe exhibited inhibitory activity close to that of galantamine (CAS 357-70-0) and did not show any selectivity between the two enzymes. Also the antimicrobial activities of III and IV derivatives have been evaluated. All III and IV derivatives exhibited poor antibacterial activities but moderate antifungal activities. ECV ? Editio Cantor Verlag.