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Cas Database

1003-04-9

1003-04-9

Identification

Synonyms:3-Oxo-2,3,4,5-tetrahydrothiophene;3-Oxotetrahydrothiophene;3-Thiacyclopentanone;3-Thiophanone;4,5-Dihydrothiophen-3(2H)-one;Dihydro-3(2H)-thiophenone;Dihydrothiophen-3-one;Tetrahydrothien-3-one;Thiolan-3-one;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
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  • Price
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  • Purchase
  • Manufacture/Brand:AHH
  • Product Description:Tetrahydrothiophen-3-one 98%
  • Packaging:250g
  • Price:$ 230
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:Tetrahydrothiophen-3-one
  • Packaging:5g
  • Price:$ 10
  • Delivery:In stock
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:Tetrahydrothiophen-3-one, 97%
  • Packaging:5g
  • Price:$ 25.5
  • Delivery:In stock
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:Tetrahydrothiophen-3-one, 97%
  • Packaging:10g
  • Price:$ 42
  • Delivery:In stock
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:Tetrahydrothiophen-3-one, 97%
  • Packaging:25g
  • Price:$ 79.6
  • Delivery:In stock
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:Tetrahydrothiophen-3-one, 97%
  • Packaging:250g
  • Price:$ 634
  • Delivery:In stock
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  • Manufacture/Brand:Alichem
  • Product Description:Dihydrothiophen-3(2H)-one
  • Packaging:1000g
  • Price:$ 360.5
  • Delivery:In stock
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  • Manufacture/Brand:Alichem
  • Product Description:Dihydrothiophen-3(2H)-one
  • Packaging:500g
  • Price:$ 226.8
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:Dihydrothiophen-3(2H)-one 98%
  • Packaging:500g
  • Price:$ 159
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:Dihydrothiophen-3(2H)-one 98%
  • Packaging:100g
  • Price:$ 38
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Relevant articles and documentsAll total 9 Articles be found

Investigation of the aroma-active compounds formed in the maillard reaction between glutathione and reducing sugars

Lee, Sang Mi,Jo, Ye-Jin,Kim, Young-Suk

, p. 3116 - 3124 (2010)

Aroma-active compounds formed during the thermal reaction between glutathione (GSH) and reducing sugars were analyzed by gas chromatography-mass spectrometry (GC-MS) and GC-olfactometry (GC-O) with aroma extract dilution analysis (AEDA). Application of AEDA to glutathione Maillard reaction products (GSH MRPs) led to the identification of 19 aroma-active compounds in the thermal reaction of glutathione with glucose or fructose. In addition, the carbohydrate module labeling (CAMOLA) approach was also employed to elucidate the formation pathways for selected target sulfur aroma compounds, such as 5-methylthiophene-2-carbaldehyde and 3-methylthiophene-2-carbaldehyde, which have not been reported previously. The intact carbon skeleton of glucose via 3-deoxyhexosone is incorporated into 5-methylthiophene-2-carbaldehyde with the hydrogen sulfide of GSH. On the other hand, the formation of 3-methylthiophene2-carbaldehyde may occur via the recombination of a C-4 sugar fragment and mercaptoacetaldehyde.

Preparation method of substituted thiophene-3-one compound

-

Paragraph 0054; 0062; 0067; 0072; 0077; 0082; 0087; 0092, (2018/08/04)

The invention provides a preparation method of a substituted thiophene-3-one compound, comprising: subjecting material A and material B to Michael addition reaction to obtain an addition product; subjecting the addition product to Dieckmann condensation reaction to obtain a substituted thiophene-3-one compound having a structure shown as formula (IV) that is shown in the description. The preparation method provided by the application has the advantages that using solvents and strong bases is not required, reaction materials are low in price and easy to obtain, no wastewater is produce, and therefore, the preparation method has good environmental friendliness; compared with existing preparation methods, the preparation method has a short synthetic route, can be performed under mild conditions and features good yield stability and good repeatability, which is helpful for greatly increasing total yield of the substituted thiophene-3-one compound and helpful for industrial popularization.

Thio-sugars. Part 10. The Nucleoside from 5-Fluoroacil and 2-Amino-2,3-dideoxy-4-thio-DL-glycero-tetrofuranose and Related Compounds

Jones, John O.,McElhinney, R. Stanley

, p. 1501 - 1517 (2007/10/02)

Another molecular combination of a chloroethylnitrosourea and a pyrimidine antimetabolite (5-fluorouracil) linked through a sugar or sugar-like moiety has been synthesised for biological testing.In this case 2-amino-2,3-dideoxy-4-thio-DL-glycero-tetrofuranose was derived from thiolan-3-one, nitrogen being introduced as azide in preference to the route involving oxime and phthalimide.Some derivatives of 3-amino-3-deoxy-4-thio-DL-erythrofuranose were prepared from trans-4-aminothiolan-3-ol, inverted by way of a fused oxazoline, but although a (5-iodouracil) nucleoside ester was obtained it proved difficult to remove the protecting groups.

Process route upstream and downstream products

Process route

methyl tetrahydrothiophen-3-one-2-carboxylate
2689-69-2

methyl tetrahydrothiophen-3-one-2-carboxylate

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

Conditions
Conditions Yield
79%
With sulfuric acid;
methyl 4-oxotetrahydrothiophene-3-carboxylate
2689-68-1,99328-39-9

methyl 4-oxotetrahydrothiophene-3-carboxylate

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

Conditions
Conditions Yield
With sulfuric acid;
1-chloro-4-iodo-butan-2-one
408326-28-3

1-chloro-4-iodo-butan-2-one

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

Conditions
Conditions Yield
With sodium sulfide; ethanol; im Wasserstoff-Strom unter Lichtausschluss;
tetrahydrothiophene-3-ol
3334-05-2,79107-71-4

tetrahydrothiophene-3-ol

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

Conditions
Conditions Yield
With nicotinamide adenine dinucleotide; horse liver alcohol dehydrogenase; In various solvent(s); at 25 ℃; Rate constant; pH 9;
potassium acetate
127-08-2

potassium acetate

4-benzhydrylthio-1-diazo-2-butanone

4-benzhydrylthio-1-diazo-2-butanone

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

benzhydryl acetate
954-67-6

benzhydryl acetate

1-acetoxy-4-benzhydrylthio-2-butanone

1-acetoxy-4-benzhydrylthio-2-butanone

Conditions
Conditions Yield
In acetic acid; at 114 ℃; for 0.0833333h;
82 % Chromat.
18 % Chromat.
acetic acid
64-19-7,77671-22-8

acetic acid

4-benzhydrylthio-1-diazo-2-butanone

4-benzhydrylthio-1-diazo-2-butanone

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

benzhydryl acetate
954-67-6

benzhydryl acetate

1-acetoxy-4-benzhydrylthio-2-butanone

1-acetoxy-4-benzhydrylthio-2-butanone

Conditions
Conditions Yield
at 114 ℃; for 0.0833333h; Product distribution; Mechanism; also in the presence of AcOK;
10 % Chromat.
90 % Chromat.
Methyl thioglycolate
2365-48-2

Methyl thioglycolate

acrylic acid methyl ester
292638-85-8,9003-21-8,96-33-3

acrylic acid methyl ester

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

Conditions
Conditions Yield
With methanolate; oxonium;
1-Oxo-tetrahydro-1λ<sup>4</sup>-thiophen-3-one

1-Oxo-tetrahydro-1λ4-thiophen-3-one

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

Conditions
Conditions Yield
With dimethylsilicon dichloride; zinc; Ambient temperature;
4-Methyl-N-[3-oxo-tetrahydro-1λ<sup>4</sup>-thiophen-(1Z)-ylidene]-benzenesulfonamide

4-Methyl-N-[3-oxo-tetrahydro-1λ4-thiophen-(1Z)-ylidene]-benzenesulfonamide

Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

Conditions
Conditions Yield
With dimethylsilicon dichloride; zinc; Ambient temperature;
Tetrahydrothiophen-3-one
1003-04-9

Tetrahydrothiophen-3-one

Conditions
Conditions Yield

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