4938-00-5

Basic information

• Product Name: danosteine
• Synonyms: danosteine;3-Thiaadipicacid;3-[(Carboxymethyl)thio]propanoic acid;3-Thiahexanedioic acid;3-(carboxymethylsulfanyl)propanoic acid
• CAS NO: 4938-00-5
• Molecular Formula: C₅H₈O₄S
• Molecular Weight: 164.17962
• EINECS: 225-578-3
• Mol File: 4938-00-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 389.2°C at 760 mmHg
• Flash Point: 189.2°C
• Appearance: /
• Density: 1.436g/cm³
• Vapor Pressure: 3.85E-07mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: danosteine(CAS DataBase Reference)
• NIST Chemistry Reference: danosteine(4938-00-5)
• EPA Substance Registry System: danosteine(4938-00-5)

Safety Data

• Hazardous Substances Data: 4938-00-5(Hazardous Substances Data)

Usage

General Description

Danosteine is a synthetic thiol compound that has been used as a mucolytic and anti-inflammatory agent. It is commonly used in the treatment of respiratory conditions such as chronic bronchitis and chronic obstructive pulmonary disease (COPD). Danosteine works by thinning and loosening mucus in the airways, making it easier to cough up and clear the lungs. It also has anti-inflammatory properties, helping to reduce inflammation in the airways and improve breathing. Danosteine has been found to be effective in improving symptoms and reducing exacerbations in patients with chronic respiratory conditions. However, it may also cause side effects such as gastrointestinal disturbances, headache, and skin reactions.

InChI:InChI=1/C5H8O4S/c6-4(7)1-2-10-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)

Upstream product

• 57-57-8 β-Propiolactone 
• 623-51-8 ethyl 2-sulfanylacetate 
• 119247-72-2 ethyl-(2-carboxy-ethyl)-carboxymethyl sulfonium ; chloride 
• 79-11-8 chloroacetic acid 
• 107-96-0 3-mercaptopropionic acid 
• 7647-01-0 hydrogenchloride 
• 646-01-5 3-(methylsulfanyl)propionic acid 
• 68-11-1 mercaptoacetic acid 
• 7400-45-5 dimethyl-3-thiaadipate 
• 20986-22-5 (2-carboxyethyl)dimethylsulfonium bromide 
• 79-10-7 acrylic acid 
• 292638-85-8 acrylic acid methyl ester 
• 141-76-4 3-iodopropanoic acid 
• 590-92-1 3-Bromopropionic acid 

Downstream Products

• 1003-04-9 Tetrahydrothiophen-3-one 
• 1451925-02-2 C₂₃H₂₂N₆O₂S₃ 
• 94822-29-4 <2-Phenylcarbamoyl-ethylmercapto>-essigsaeure-anilid 
• 80278-72-4 ethyl 3-(ethoxycarbonylmethylmercapto)-propanoate 

Relevant articles and documents

Preparation method of substituted thiophene-3-one compound

The invention provides a preparation method of a substituted thiophene-3-one compound, comprising: subjecting material A and material B to Michael addition reaction to obtain an addition product; subjecting the addition product to Dieckmann condensation reaction to obtain a substituted thiophene-3-one compound having a structure shown as formula (IV) that is shown in the description. The preparation method provided by the application has the advantages that using solvents and strong bases is not required, reaction materials are low in price and easy to obtain, no wastewater is produce, and therefore, the preparation method has good environmental friendliness; compared with existing preparation methods, the preparation method has a short synthetic route, can be performed under mild conditions and features good yield stability and good repeatability, which is helpful for greatly increasing total yield of the substituted thiophene-3-one compound and helpful for industrial popularization.

HETEROCYCLIC INHIBITORS OF GLUTAMINASE

The invention relates to the heterocyclic compounds of Formula (I) as defined further herein, and pharmaceutical preparations thereof. The invention further relates to methods of treating cancer, immunological or neurological diseases using the heterocyclic compounds of the invention.