1005-38-5

Basic information

• Product Name: 4-Amino-6-chloro-2-(methylthio)pyrimidine
• Synonyms: 4-Pyrimidinamine, 6-chloro-2-(methylthio)-;6-Chloro-2-(methylsulfanyl)-4-pyrimidinylamine;U 8342;2-METHYLMERCAPTO-4-AMINO-AMINO-6-CHLOROPYRIMIDINE;4-AMINO-6-CHLORO-2-METHYLMERCAPTOPYRIMIDINE;4-AMINO-6-CHLORO-2-(METHYLTHIO)PYRIMIDINE;6-AMINO-4-CHLORO-2-METHYLMERCAPTOPYRIMIDINE;6-CHLORO-2-(METHYLTHIO)PYRIMIDIN-4-AMINE
• CAS NO: 1005-38-5
• Molecular Formula: C₅H₆ClN₃S
• Molecular Weight: 175.64
• EINECS: 213-734-3
• Product Categories: Sulphur Derivatives;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Building Blocks;C4 to C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 1005-38-5.mol

Chemical Properties

• Melting Point: 130-132 °C(lit.)
• Boiling Point: 338.7°Cat760mmHg
• Flash Point: 158.6°C
• Appearance: Off-white to beige or yellow/Crystalline Powder
• Density: 1.395 (estimate)
• Vapor Pressure: 9.64E-05mmHg at 25°C
• Refractive Index: 1.6100 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 1.11±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-6-chloro-2-(methylthio)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)
• EPA Substance Registry System: 4-Amino-6-chloro-2-(methylthio)pyrimidine(1005-38-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 1005-38-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-6-chloro-2-(methylthio)pyrimidine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
As a halogenated heterocycle, 4-Amino-6-chloro-2-(methylthio)pyrimidine is utilized in chemical research for the exploration of novel reactions and the synthesis of complex organic molecules. Its versatility makes it a valuable tool for advancing scientific knowledge in the field of organic chemistry.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006

InChI:InChI=1/C5H6ClN3S/c1-10-5-8-3(6)2-4(7)9-5/h2H,1H3,(H2,7,8,9)

Upstream product

• 6299-25-8 4,6-Dichloro-2-(methylthio)pyrimidine 
• 1074-41-5 6-amino-2-methylsulfanylpyrimidin-4(3H)-one 
• 7664-41-7 ammonia 
• 1074-41-5 2-(Methylthio)-4-hydroxy-6-aminopyrimidine 

Downstream Products

• 52222-40-9 N⁴,N⁴-dimethyl-2-methylsulfanyl-pyrimidine-4,6-diyldiamine 
• 108481-08-9 N⁴-methyl-2-methylsulfanyl-N⁴-phenyl-pyrimidine-4,6-diyldiamine 
• 3289-35-8 4-Chlor-cytosin 
• 63931-22-6 5-bromo-6-chloro-2-(methylthio)pyrimidine-4-amine 
• 81587-41-9 N-6'-chloro-2'<1H>-thioxo-3'-pyridyl-4-amino-2-methylthio-6-pyrimidinylamine 
• 133030-35-0 1-(6'-chloro-2'-methylthiopyrimidin-4'-yl)-3-p-toluenesulfonylurea 
• 81587-39-5 2-(4-amino-2-methylthiopyrimidin-6-ylamino)-6-methyl-1H-pyridinium-3-thiolate 
• 1004-38-2 2,4,6-triaminopyrimidine 
• 1005-39-6 4,6-diamino-2-methylthiopyrimidine 
• 60722-63-6 N⁴-benzyl-2-methylsulfanyl-pyrimidine-4,6-diamine 
• 339016-22-7 6-chloro-N-(4-fluorophenyl)-2-(methylthio)pyrimidin-4-amine 
• 86626-97-3 (6-chloro-2-methylsulfanylpyrimidin-4-yl)phenylamine 
• 872059-27-3 7-chloro-5-(methylthio)imidazo[1,2-c]pyrimidine 
• 932046-86-1 2-methylsulfanyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-4-ylamine 

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