1007-49-4

Basic information

• Product Name: 2-PYRIDYLMETHYL ACETATE
• Synonyms: pyridine-2-methyl acetate;2-Picolyl acetate;2-Pyridinemethanol acetate;pyridin-2-ylmethyl acetate;pyridin-2-ylmethyl ethanoate;2-acetoxymethylpyridine;2-pyridinemethanol,acetate(ester);2-pyridylcarbinolacetate(ester)
• CAS NO: 1007-49-4
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16
• EINECS: 213-756-3
• Mol File: 1007-49-4.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 211.3°Cat760mmHg
• Flash Point: 81.6°C
• Appearance: /
• Density: 1.115g/cm³
• Vapor Pressure: 0.184mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: 2-PYRIDYLMETHYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDYLMETHYL ACETATE(1007-49-4)
• EPA Substance Registry System: 2-PYRIDYLMETHYL ACETATE(1007-49-4)

Safety Data

• Hazardous Substances Data: 1007-49-4(Hazardous Substances Data)

Usage

General Description

2-Pyridylmethyl acetate is a chemical compound with the molecular formula C9H9NO2. It is an ester with a pyridine ring and is often used as a flavoring agent in the food and beverage industry. It has a fruity, sweet, and floral aroma, making it a popular choice for adding a pleasant scent to various products. 2-PYRIDYLMETHYL ACETATE is also used in the production of perfumes and as a fragrance ingredient in personal care products. Additionally, it can act as an intermediate in organic synthesis and is utilized in the pharmaceutical industry for the development of various drugs and medications. Overall, 2-pyridylmethyl acetate has a wide range of industrial applications due to its pleasant aroma and chemical properties.

InChI:InChI=1/C8H9NO2/c1-7(10)11-6-8-4-2-3-5-9-8/h2-5H,6H2,1H3

Upstream product

• 274-59-9 triazolopyridine 
• 586-98-1 2-Hydroxymethylpyridine 
• 581-55-5 benzylidene 1,1-diacetate 
• 109-06-8 α-picoline 
• 108-24-7 acetic anhydride 
• 141-78-6 ethyl acetate 
• 93-91-4 1-phenylbutan-1,3-dione 
• 123-54-6 acetylacetone 
• 2466-76-4 N-Acetylimidazole 
• 64-19-7 acetic acid 
• 2524-52-9 ethyl-2-picolinate 
• 931-19-1 2-methylpyridine N-oxide 
• 463-51-4 Ketene 
• 7664-93-9 sulfuric acid 

Downstream Products

• 122307-92-0 6-Phenyl-2-(pyridin-2-ylmethanesulfinyl)-3H-thieno[3,4-d]imidazole 
• 122307-83-9 6-Phenyl-2-(pyridin-2-ylmethylsulfanyl)-3H-thieno[3,4-d]imidazole 
• 107624-25-9 2-(benzyloxymethyl)pyridine 
• 6885-17-2 diacetoxy-pyridin-2-yl-methane 
• 10242-36-1 2-(hydroxymethyl)pyridine 1-oxide 
• 586-98-1 2-Hydroxymethylpyridine 
• 4377-33-7 2-chloromethylpyridine 
• 129116-70-7 2,4,6-Trimethyl-benzenesulfonate2-acetoxymethyl-1-amino-pyridinium; 

Relevant articles and documents

Simple preparation and application of TEMPO-coated Fe3O 4 superparamagnetic nanoparticles for selective oxidation of alcohols

The organic oxidant TEMPO (2,2,4,4-tetramethylpiperdine-1-oxyl) was immobilized on iron oxide (Fe3O4) superparamagnetic nanoparticles by employing strong metal-oxide chelating phosphonates and azide/alkyne "click" chemistry. This simple preparation yields recyclable TEMPO-coated nanoparticles with good TEMPO loadings. They have excellent magnetic response and efficiently catalyze the oxidation of a wide range of primary and secondary alcohols to aldehydes, ketones, and lactones under either aerobic acidic MnII/CuII oxidizing Minisci conditions, or basic NaOCl Anelli conditions. The nanoparticles could be recycled more than 20 times under the Minisci conditions and up to eight times under the Anelli conditions with good to excellent substrate conversions and product selectivities. Immobilization of the catalyst through a phosphonate linkage allows the particles to withstand acidic oxidizing environments with minimal catalyst leaching. Clicking TEMPO to the phosphonate prior to phosphonate immobilization, rather than after, ensures the clicked catalyst is the only species on the particle surface. This facilitates quantification of the catalyst loading. The stability of the phosphonate linker and simplicity of this catalyst immobilization method make this an attractive approach for tethering catalysts to oxide supports, creating magnetically separable catalysts that can be used under neutral or acidic conditions. Recycling to a different TEMPO: An extremely simple and economic synthesis of a recyclable 2,2,4,4-tetramethylpiperdine-1-oxyl(TEMPO)-coated superparamagnetic catalyst is described. The catalyst shows excellent performance in the rapid oxidation of primary and secondary benzylic and aliphatic alcohols by using oxygen and MnII/CuII or biphasic NaOCl/KBr conditions.

The reactions of 2-picoline 1-oxide with acid anhydride.

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Oxidative "reverse-esterification" of ethanol with benzyl/alkyl alcohols or aldehydes catalyzed by supported rhodium nanoparticles

A very unusual role of polystyrene stabilized rhodium (Rh@PS) nanoparticles as a supported catalyst is described for "reverse-esterification" of ethanol with benzyl/alkyl alcohols or aldehydes. Faster and selective oxidation of ethanol to acetaldehyde and H2 under Rh@PS catalyzed conditions which restricted further oxidation of benzyl/alkyl alcohols and their in situ reaction gave the corresponding acetate esters following the dehydrogenative-coupling approach. A hitherto redox dehydrogenative-coupling of ethanol and aldehydes has also been explored for the same acetate ester synthesis under Rh@PS catalyzed conditions.

Supramolecular Catalysis of Acyl Transfer within Zinc Porphyrin-Based Metal-Organic Cages

To illustrate the supramolecular catalysis process in molecular containers, two porphyrinatozinc(II)-faced cubic cages with different sizes were synthesized and used to catalyze acyl-transfer reactions between N-acetylimidazole (NAI) and various pyridylcarbinol (PC) regioisomers (2-PC, 3-PC, and 4-PC). A systemic investigation of the supramolecular catalysis occurring within these two hosts was performed, in combination with a host-guest binding study and density functional theory calculations. Compared to the reaction in a bulk solvent, the results that the reaction of 2-PC was found to be highly efficient with high rate enhancements (kcat/kuncat = 283 for Zn-1 and 442 for Zn-2), as well as the different efficiencies of the reactions with various ortho-substituted 2-PC substrates and NAI derivates should be attributed to the cages having preconcentrated and preoriented substrates. The same cage displayed different catalytic activities toward different PC regioisomers, which should be mainly attributed to different binding affinities between the respective reactant and product with the cages. Furthermore, control experiments were carried out to learn the effect of varying reactant concentrations and product inhibition. The results all suggested that, besides the confinement effect caused by the inner microenvironment, substrate transfer, including the encapsulation of the reactant and the release of products, should be considered to be a quite important factor in supramolecular catalysis within a molecular container.

Formyloxyacetoxyphenylmethane and 1,1-diacylals as versatile O-formylating and O-acylating reagents for alcohols

Formyloxyacetoxyphenylmethane, symmetric 1,1-diacylals and mixed 1-pivaloxy-1-acyloxy-1-phenylmethanes have been used as moisture stable O-formylating and O-acylating reagents for primary and secondary alcohols, allylic alcohols and phenols under solvent/catalyst free conditions to afford their corresponding esters in good yield.

Synthesis method for 2-pyridylaldehyde

The invention belongs to the field of organic chemistry and particularly relates to a synthesis method for 2-pyridylaldehyde. The method comprises the following steps of (1) adopting 2-methylpyridine as a raw material and obtaining 2-pyridine n-oxide through oxidation reaction under an acid condition; (2) synthesizing acetic acid-2-piperidinecarbonitrile by using the 2-pyridine n-oxide through acetic anhydride acylation rearrangement; (3) hydrolyzing the acetic acid-2-piperidinecarbonitrile to obtain 2-pyridinemethanol; and (4) carrying out oxidation reaction on the 2-pyridinemethanol to obtain the 2-pyridylaldehyde. The synthesis method has the advantages of being high in total yield, low in raw material price, short in reaction time, mild in condition and simple in technological operation.