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1011-92-3

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1011-92-3 Usage

General Description

Alpha-Cyanocinnamic Acid (C9H7NO2) is an organic compound classified as an acid and more specifically, an alpha, beta unsaturated carboxylic acid. It comprises of a benzene ring attached to a cyanocinnamic acid moiety. The molecular weight of this compound is 159.156 g/mol. It appears as a white crystalline solid and is used in various industries, particularly in scientific research due to its influence on plant growth and development. There's evidence suggesting its role in enhancing plant resistance against diseases, improving photosynthesis, and promoting nutritional uptake. However, due to limited research, its potential toxicity or safety for human consumption is not well understood.

Check Digit Verification of cas no

The CAS Registry Mumber 1011-92-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,1 and 1 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1011-92:
(6*1)+(5*0)+(4*1)+(3*1)+(2*9)+(1*2)=33
33 % 10 = 3
So 1011-92-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H7NO2/c11-7-9(10(12)13)6-8-4-2-1-3-5-8/h1-6H,(H,12,13)/p-1/b9-6+

1011-92-3 Well-known Company Product Price

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  • TCI America

  • (C0447)  α-Cyanocinnamic Acid  >98.0%(HPLC)(T)

  • 1011-92-3

  • 25g

  • 990.00CNY

  • Detail
  • Alfa Aesar

  • (L04133)  alpha-Cyanocinnamic acid, 96%   

  • 1011-92-3

  • 5g

  • 522.0CNY

  • Detail
  • Alfa Aesar

  • (L04133)  alpha-Cyanocinnamic acid, 96%   

  • 1011-92-3

  • 25g

  • 1250.0CNY

  • Detail

1011-92-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name α-Cyanocinnamic Acid

1.2 Other means of identification

Product number -
Other names α-CYANOCINNAMIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1011-92-3 SDS

1011-92-3Relevant articles and documents

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Smith,Horwitz

, p. 3418 (1949)

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Synthesis, in vitro cytotoxicity, and molecular docking study of novel 3,4-dihydroisoquinolin-1(2H)-one based piperlongumine analogues

Kulkarni, Mahesh R.,Lad, Nitin P.,Khedkar, Vijay M.,Gaikwad, Nitin D.

, p. 1359 - 1370 (2021)

With the aim of expanding the scope of SAR on piperlongumine (PL), a naturally occurring anticancer molecule, we have designed a novel hybrid molecule bearing 3,4-dihydroisoquinolin-1(2H)-one and trans-cinnamic acids. The structure, based on hybridization strategy, is used for hybridization of naturally occurring scaffolds. We have synthesized 14 hybrid molecules by coupling 3,4-dihydroisoquinolin-1(2H)-one core with cinnamic acids using the mix anhydride approach. The newly synthesized inhibitors were evaluated for cell viability against breast cancer MCF-7 and cervical cancer HeLa cell lines. Furthermore, the active compounds were screened for their potential in breast cancer MDA-MB-231, cervical cancer C33A cell lines, prostate cancer DU-145, PC-3, and normal VERO cells. From the series, compound 10g was seen to inhibit MCF-7 cell growth significantly with GI50 50 = 20 μM) and C33A (GI50 = 3.2 μM). While the inhibitor 10i inhibits MCF-7 breast cancer cell growth GI50 = 3.42 μM along with inhibition of cell growth in MDA-MB-231 (GI50 = 30 μM), HeLa (GI50 = 7.67 μM), C33A (GI50 = 13 μM), DU-145 (GI50 = 6.45 μM), PC-3 (GI50 = 8.68 μM), and VERO (GI50 = 2.93 μM), respectively. Furthermore, molecular docking study demonstrated these compounds could bind tightly to the colchicine domain of tubulin through a network of favorable steric and electrostatic interactions and thus act as a tubulin polymerization inhibitor.

Discovery of novel dihydroartemisinin-cinnamic hybrids inducing lung cancer cells apoptosis via inhibition of Akt/Bad signal pathway

Hu, Yanping,Wang, Yujin,Li, Na,Chen, Li,Sun, Jianbo

, (2021/04/27)

A series of dihydroartemisinin-cinnamic acid hybrids were designed, synthesized and evaluated. Most of the tested compounds showed enhanced anti-proliferative activities than artemisinin and dihydroartemisinin, among which 16 g had the superior potency with IC50 values ranging from 5.07 μM to 7.88 μM against four tested cancer cell lines. The cell cycle arrest revealed that 16 g induced A549 cell cycle arrest at G0/G1 phase via regulation of G1-related protein expression (Cdk4). Further mechanism studies reveal that 16 g induced A549 cells apoptosis via inhibiting Akt/Bad pathway. Moreover, 16 g depolarized the mitochondria membrane potentials and induced ROS generation in A549. Additionally, 16 g blocked migration of A549 cells in a concentration-dependent manner. What's more, 16 g is barely nontoxic to zebrafish embryos. Overall, the cell cycle arrest, inhibition of Akt/Bad signal pathway, ROS generation and migration blocked might explain the potent anti-proliferative activities of these compounds.

Graphene based material as a base catalyst for solvent free Aldol condensation and Knoevenagel reaction at room temperature

Islam, Sk Manirul,Roy, Anupam Singha,Dey, Ram Chandra,Paul, Sumantra

, p. 66 - 73 (2014/08/05)

Graphene oxide (GO) acts as a highly active heterogeneous base catalyst for a wide variety of reactions. Here we have described the catalytic activities of GO in the condensation reaction of various substituted benzaldehydes with acetophenone (aldol condensation) and with active methylene compound malononitrile (Knoevenagel reaction) at room temperature under solvent free condition. GO is characterized by powder X-ray diffraction (XRD), UV-visible spectra, Fourier transform infrared spectroscopy (FT-IR) and AFM. The experimental results showed that the GO had higher catalytic activity and it can be recycled without significant loss of its activity.

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