106833-79-8

Basic information

• Product Name: 2-PHENYL-1,3-OXAZOLE-5-CARBOXYLIC ACID
• Synonyms: 2-PHENYL-1,3-OXAZOLE-5-CARBOXYLIC ACID;Ec-000.1791;5-Oxazolecarboxylic acid, 2-phenyl-
• CAS NO: 106833-79-8
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.17
• Mol File: 106833-79-8.mol

Chemical Properties

• Melting Point: 217-218 °C
• Boiling Point: 396.4°Cat760mmHg
• Flash Point: 193.5°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• PKA: 2.38±0.10(Predicted)
• CAS DataBase Reference: 2-PHENYL-1,3-OXAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-1,3-OXAZOLE-5-CARBOXYLIC ACID(106833-79-8)
• EPA Substance Registry System: 2-PHENYL-1,3-OXAZOLE-5-CARBOXYLIC ACID(106833-79-8)

Safety Data

• Hazardous Substances Data: 106833-79-8(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-Phenyl-1,3-oxazole-5-carboxylic acid is used as a building block in chemical synthesis for its ability to undergo transformations due to the presence of functional groups such as the phenyl ring, oxazole ring, and carboxylic acid group.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Phenyl-1,3-oxazole-5-carboxylic acid is used as a potential candidate for drug development, given its structural features that may allow for the creation of new therapeutic agents through chemical modifications.
Used in Material Science:
2-Phenyl-1,3-oxazole-5-carboxylic acid may be utilized in material science for the development of new materials with specific properties, such as those with enhanced stability or reactivity, based on its chemical structure and functional groups.
Note: The specific applications mentioned above are hypothetical and provided as examples based on the compound's structural features. Further research and experimentation are necessary to determine the actual uses and properties of 2-Phenyl-1,3-oxazole-5-carboxylic acid in various industries.

InChI:InChI=1/C10H7NO3/c12-10(13)8-6-11-9(14-8)7-4-2-1-3-5-7/h1-6H,(H,12,13)

Upstream product

• 20662-88-8 2-phenyloxazole 
• 98-88-4 benzoyl chloride 
• 1464-98-8 N-(prop-2-yn-1-yl)benzamide 
• 65-85-0 benzoic acid 
• 106833-83-4 methyl 2-phenyl-1,3-oxazole-5-carboxylate 
• 89928-06-3 methyl ester of 3-(N-benzoyl)aminopropionic acid 
• 90701-94-3 (E)-5-(iodomethylene)-2-phenyl-4,5-dihydrooxazole 
• 92629-13-5 2?phenyloxazole?5?carbaldehyde 

Downstream Products

• 1442120-50-4 4-methyl-2-({1-[(2-phenyloxazol-5-yl)carbonyl]piperidin-4-yl}methyl)-N-(2,2,2-trifluoroethyl)-2H-indazole-5-carboxamide 
• 62921-42-0 5-(4-methoxyphenyl)-2-phenyl-1,3-oxazole 
• 1227747-50-3 C₂₁H₁₆N₂O₄ 
• 106833-87-8 N-(2-Hydroxyethyl)amide of 2-phenyloxazole-5-carboxylic acid 
• 106833-86-7 4,5-Dihydro-2'-phenyl-2,5'-bioxazole 
• 106833-92-5 2'-Phenyl-2,5'-bioxazole 
• 39819-42-6 amide of 2-phenyloxazole-5-carboxylic acid 
• 106833-83-4 methyl 2-phenyl-1,3-oxazole-5-carboxylate 

Relevant articles and documents

SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS

The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.

Preparation of oxazolines and oxazoles via a PhI(OAc)2-promoted cyclization of N-propargylamides

A metal-free cyclization of N-propargylamides for the synthesis of various oxazolines and oxazoles via a 5-exo-dig process is presented. Using (diacetoxyiodo)benzene (PIDA) as a reaction promoter and lithium iodide (LiI) as an iodine source, intramolecula

Merging gold catalysis, organocatalytic oxidation, and Lewis acid catalysis for chemodivergent synthesis of functionalized oxazoles from: N -propargylamides

Novel catalytic systems consisting of cationic gold complexes, N-hydroxyphthalimide (NHPI), and transition-metal-based Lewis acids have been developed for the one-pot synthesis of functionalized oxazoles from N-propargylamides with excellent functional group tolerance. These transformations demonstrated the excellent compatibility of homogeneous gold catalysis with organocatalytic oxidative carbon-nitrogen bond formations using tert-butyl nitrite as the terminal oxidant. Moreover, oxazolecarbonitriles or carboxamides can be easily synthesized in a one-pot protocol according to the different synthetic requirements.

PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5′ and R6 are described herein.

SYNTHESIS, STRUCTURE, AND SPECTRAL PROPERTIES OF SOME BIOXAZOLES

Syntheses of systems containing two oxazole rings from aldehydes obtained by formylating 2-phenyl-, 2-(2-furyl)-, and 2-(2-thienyl)oxazole have been developed.Terephthalate and thiophen-2,5-dicarboxylate esters have been used to obtain 2,2'-(1,4-phenylene)- and 2,2'-(2,5-thienylene)bisoxazoles.The PMR, UV, and luminescence spectra of these systems have been examined, and quantum chemical calculations carried out in the PPP approximation.