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Cas Database

1070-19-5

1070-19-5

Identification

Synonyms:Formicacid, azido-, tert-butyl ester (6CI,7CI,8CI);1,1-Dimethylethyl azidoformate;BOC-azide;NSC 95410;tert-Butoxycarbonyl azide;tert-Butyl azidoformate;tert-Butyloxycarbonyl azide;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:TERT-BUTYL AZIDOFORMATE 95.00%
  • Packaging:5MG
  • Price:$ 499.65
  • Delivery:In stock
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Relevant articles and documentsAll total 19 Articles be found

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Laszlo, Pierre,Polla, Eugenio

, p. 3701 - 3704 (1984)

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Solid-phase synthesis of muramyl dipeptide (MDP) derivatives using a multipin method

Liu, Gang,Zhang, Shuo-De,Xia, Shu-Quan,Ding, Zhen-Kai

, p. 1361 - 1363 (2000)

Solid-phase synthetic method of muramyl dipeptide derivatives is reported. A diverse library of muramyl dipeptides could be potentially synthesized by acylation, reductive alkylation, sulfonamide formation, urea formation, N-alkylation, amine addition, or component Ugi reactions based on this method for drug screening. (C) 2000 Elsevier Science Ltd. All rights reserved.

The enantioselective addition of 1-fluoro-1-nitro(phenylsulfonyl)methane to isatin-derived ketimines

Urban,Franc,Hofmanová,Císa?ová,Vesely

supporting information, p. 9071 - 9076 (2017/11/14)

An asymmetric organocatalytic addition of fluorinated phenylsulfonylnitromethane to isatin-derived ketimines was developed. The reaction was efficiently catalyzed by a chiral tertiary amine, cinchonine. This methodology provides a new type of optically active compound with two adjacent quaternary carbon stereocenters in good yield (up to 96%), with moderate diastereoselectivity (up to 5.7:1 dr) and excellent enantioselectivity (up to 98/96% ee).

Rhodium-Catalyzed N-tert-Butoxycarbonyl (Boc) Amination by Directed C H Bond Activation

Wippich, Julian,Truchan, Nadina,Bach, Thorsten

supporting information, p. 2083 - 2087 (2016/07/16)

N-tert-Butoxycarbonyl azide (BocN3) was shown to be an efficient and economic source for the directed introduction of N-Boc protected amino groups into the thiophene and benzene nucleus. Yields for the amination of 2-pyridin-2-ylthiophenes (10 examples) were 52–88%. For the amination of the respective benzenes (10 examples) yields between 54% and 99% were recorded with an improved reactivity observed for substrates that bear an electron-withdrawing group. The reaction was applied to short total syntheses of the indoloquinoline alkaloids quindoline and cryptolepine. The facile removal of the Boc protecting group was the key to the success of the syntheses. The scope of the reaction was extended to a C(sp3) H bond amination and to the amination of 2-phenyloxazoline. For the amination of 2-pyridin-2-ylbenzene a kinetic deuterium isotope effect of 2.0 was determined. (Figure presented.) .

PYRAZOLE COMPOUNDS HAVING THERAPEUTIC EFFECT ON MULTIPLE MYELOMA

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Paragraph 0196; 0197, (2013/10/07)

Novel therapeutic agents for myeloma are provided. A therapeutic agent for multiple myeloma containing a pyrazole compound represented by the formula (1): wherein R1 is C1-C6 alkyl, C1-C6 alkyl substituted with R17, C1-C6 haloalkyl, phenyl, phenyl substituted with a R11's or the like, R2 is a hydrogen atom, C1-C6 alkyl, phenyl or phenyl optionally substituted with e R21's or the like, R3 is a hydrogen atom or the like, X is a single bond or —(CR6, R7)n—, each of R4 and R5 is independently C1-C6 alkyl or the like, R6 and R7 are hydrogen atoms or C1-C6 alkyl, R8 is phenyl, phenyl optionally substituted with k R81's or the like, a tautomer of the compound or a pharmaceutically acceptable salt or solvate thereof, as an active ingredient.

Process route upstream and downstream products

Process route

t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

Conditions
Conditions Yield
With acetic acid; sodium nitrite; In water; at 0 - 20 ℃; for 2.08333h;
100%
With potassium hydrogencarbonate; sodium nitrite; In water; acetic acid;
97%
With acetic acid; sodium nitrite; at 0 ℃; for 30h;
92%
With nitrosonium tetrafluoroborate; In dichloromethane; at -40 ℃; for 0.166667h;
48%
With acetic acid; sodium nitrite;
With sodium nitrite; In water; acetic acid; for 1h; Ambient temperature;
With sodium nitrite; In water; acetic acid; for 1h; Yield given; Ambient temperature;
With acetic acid; sodium nitrite;
With acetic acid; sodium nitrite; at 0 ℃; for 0.5h;
With ferric nitrate; In dichloromethane; for 2.5h; Yield given; Heating;
With acetic acid; sodium nitrite; In water; for 0.5h; Cooling with ice;
With acetic acid; sodium nitrite; In water; for 0.5h; Cooling with ice;
With acetic acid; sodium nitrite; In water; at 0 ℃; for 0.75h;
tert-butyl chloroformate
24608-52-4

tert-butyl chloroformate

N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

Conditions
Conditions Yield
With sodium azide; 18-crown-6 ether; In tetrahydrofuran; at 20 ℃; for 96h;
78%
With sodium azide; In acetone; at 20 ℃; Darkness;
dichloromethane
75-09-2

dichloromethane

1-amino-2-propene
107-11-9,30551-89-4

1-amino-2-propene

N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

N-tert-butoxycarbonylprop-2-en-1-amine
78888-18-3

N-tert-butoxycarbonylprop-2-en-1-amine

Conditions
Conditions Yield
With triethylamine;
di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: hydrazine hydrate / isopropyl alcohol / 0 - 25 °C
2: acetic acid; sodium nitrite / water / 0.75 h / 0 °C
With hydrazine hydrate; acetic acid; sodium nitrite; In water; isopropyl alcohol;
phosgene
75-44-5

phosgene

<i>tert</i>-butyl alcohol
75-65-0

tert-butyl alcohol

N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

Conditions
Conditions Yield
Multistep reaction; (i) Py, Et2O, (ii) N,N,N',N'-tetramethyl-guanidine azide, CHCl3;
N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

Conditions
Conditions Yield
69%
51%
N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

N-tert-butoxycarbonylprop-2-en-1-amine
78888-18-3

N-tert-butoxycarbonylprop-2-en-1-amine

Conditions
Conditions Yield
N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

N-tert-butoxycarbonyl-3-aminopropanol
58885-58-8

N-tert-butoxycarbonyl-3-aminopropanol

Conditions
Conditions Yield
With triethylamine; In 1,4-dioxane; water;
N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

N-methylglycine methyl ester hydrochloride
13515-93-0

N-methylglycine methyl ester hydrochloride

methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
42492-57-9

methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate

Conditions
Conditions Yield
N-(tert-butyloxycarbonyl) azide
1070-19-5

N-(tert-butyloxycarbonyl) azide

6-aminohexanoic acid
60-32-2,93208-38-9

6-aminohexanoic acid

6-(tert-butoxycarbonylamino)hexanoic acid
6404-29-1

6-(tert-butoxycarbonylamino)hexanoic acid

Conditions
Conditions Yield
With water; magnesium oxide; In 1,4-dioxane; at 50 ℃; for 26h;
96%
With sodium hydroxide; In 1,4-dioxane; water; for 4h; Ambient temperature;
93.6%

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