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110333-07-8

110333-07-8

Identification

Synonyms:5-Chlormethyl-chinolin;5-chloromethyl-quinoline;Quinoline,5-(chloromethyl);

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:5-(Chloromethyl)quinoline
  • Packaging:50mg
  • Price:$ 175
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:5-(Chloromethyl)quinoline 95+%
  • Packaging:1g
  • Price:$ 987
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:5-(chloromethyl)quinoline 95%
  • Packaging:1g
  • Price:$ 931
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:5-(CHLOROMETHYL)QUINOLINE 95.00%
  • Packaging:5MG
  • Price:$ 503.4
  • Delivery:In stock
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  • Manufacture/Brand:AccelPharmtech
  • Product Description:5-(chloromethyl)-Quinoline 97.00%
  • Packaging:25G
  • Price:$ 6000
  • Delivery:In stock
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  • Manufacture/Brand:AccelPharmtech
  • Product Description:5-(chloromethyl)-Quinoline 97.00%
  • Packaging:5G
  • Price:$ 3230
  • Delivery:In stock
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  • Manufacture/Brand:AccelPharmtech
  • Product Description:5-(chloromethyl)-Quinoline 97.00%
  • Packaging:1G
  • Price:$ 1890
  • Delivery:In stock
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Relevant articles and documentsAll total 4 Articles be found

PYRIDAZINONES AND METHODS OF USE THEREOF

-

Page/Page column 251, (2019/04/11)

Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

Yu, Zhiyong,Brannigan, James A.,Rangachari, Kaveri,Heal, William P.,Wilkinson, Anthony J.,Holder, Anthony A.,Leatherbarrow, Robin J.,Tate, Edward W.

, p. 1767 - 1772 (2015/10/20)

N-Myristoyltransferase (NMT) represents an attractive drug target in parasitic infections such as malaria due to its genetic essentiality and amenability to inhibition by drug-like small molecules. Scaffold simplification from previously reported inhibitors containing bicyclic cores identified phenyl derivative 3, providing a versatile platform to study the effects of substitution on the scaffold, which yielded pyridyl 19. This molecule exhibited improved enzyme and cellular potency, and reduced lipophilicity compared to inhibitor 3. Further structure-based inhibitor design led to the discovery of 30, the most potent inhibitor in this series, which showed single-digit nM enzyme affinity and sub-μM anti-plasmodial activity.

Process route upstream and downstream products

Process route

quinolin-5-ylmethanol
16178-42-0

quinolin-5-ylmethanol

5-(chloromethyl)quinoline
110333-07-8

5-(chloromethyl)quinoline

Conditions
Conditions Yield
With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 16h;
89.62%
With thionyl chloride; at 20 ℃; for 2.16667h; Reflux;
67%
With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 3h;
With thionyl chloride; In dichloromethane;
5-(chloromethyl)quinoline
110333-07-8

5-(chloromethyl)quinoline

Conditions
Conditions Yield
With thionyl chloride;
quinoline-5-carbaldehyde
22934-41-4

quinoline-5-carbaldehyde

5-(chloromethyl)quinoline
110333-07-8

5-(chloromethyl)quinoline

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 8 h / 0 - 20 °C
2: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 °C
With sodium tetrahydroborate; methanesulfonyl chloride; triethylamine; In methanol; dichloromethane;
5-(chloromethyl)quinoline
110333-07-8

5-(chloromethyl)quinoline

C<sub>12</sub>H<sub>14</sub>N<sub>2</sub>O<sub>3</sub>
167626-44-0

C12H14N2O3

C<sub>22</sub>H<sub>21</sub>N<sub>3</sub>O<sub>3</sub>

C22H21N3O3

Conditions
Conditions Yield
With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.75h;
75%
5-(chloromethyl)quinoline
110333-07-8

5-(chloromethyl)quinoline

p-Trifluoromethylbenzylamine
3300-51-4

p-Trifluoromethylbenzylamine

5,5'-(4-(trifluoromethyl)benzylazanediyl)bis-(methylene)diquinoline
1146365-37-8

5,5'-(4-(trifluoromethyl)benzylazanediyl)bis-(methylene)diquinoline

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 4h;
65%
5-(chloromethyl)quinoline
110333-07-8

5-(chloromethyl)quinoline

C<sub>11</sub>H<sub>9</sub>ClN<sub>2</sub>O<sub>3</sub>
1421365-17-4

C11H9ClN2O3

C<sub>21</sub>H<sub>16</sub>ClN<sub>3</sub>O<sub>3</sub>
1421365-49-2

C21H16ClN3O3

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
sodium cyanide
773837-37-9

sodium cyanide

5-(chloromethyl)quinoline
110333-07-8

5-(chloromethyl)quinoline

2-(quinolin-5-yl)acetonitrile
555155-04-9

2-(quinolin-5-yl)acetonitrile

Conditions
Conditions Yield
In dimethyl sulfoxide; at 60 ℃; for 1h;
157 mg
5-(chloromethyl)quinoline
110333-07-8

5-(chloromethyl)quinoline

C<sub>12</sub>H<sub>14</sub>N<sub>2</sub>O<sub>3</sub>
167626-44-0

C12H14N2O3

C<sub>20</sub>H<sub>18</sub>N<sub>4</sub>O<sub>3</sub>

C20H18N4O3

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C
2: hydroxylamine / methanol; dichloromethane / 0 - 20 °C
With hydroxylamine; sodium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide;

Global suppliers and manufacturers

Global( 8) Suppliers
  • Company Name
  • Business Type
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  • Main Products
  • Country
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
  • Chemlyte Solutions
  • Business Type:Other
  • Contact Tel:+86-189 8945 5137
  • Emails:sales@chemlytesolutions.com
  • Main Products:198
  • Country:China (Mainland)
  • ENAO Chemical Co, Limited
  • Business Type:Lab/Research institutions
  • Contact Tel:86--15307605669
  • Emails:sales@enaochem.com
  • Main Products:1
  • Country:China (Mainland)
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