Welcome to LookChem.com Sign In|Join Free

CAS

  • or

113-92-8

Post Buying Request

113-92-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

113-92-8 Usage

Description

Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 113-92-8 differently. You can refer to the following data:
1. An antagonist of the histamine H1-receptor
2. Antihistaminic
3. (±)-Chlorpheniramine maleate salt has been used:as H1 receptor antagonist to determine the receptor functionto block the effect of compound 48/80 on plasma IGF-Ias a standard for fast sensing and determination by sequential injector coupled with potentiometer

Brand name

Trimeton (Schering-Plough); Teldrin (GlaxoSmithKline).

General Description

Different sources of media describe the General Description of 113-92-8 differently. You can refer to the following data:
1. Chlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.
2. Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.

Air & Water Reactions

Water soluble.

Reactivity Profile

A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.

Biochem/physiol Actions

Chlorpheniramine maleate (CPM) can prevent rhinitis and urticaria. It is used to cure several allergic conditions. This antihistamine is used in small-animal veterinary practices.

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Chlorpheniramine is one the more commonly used antihistamines in the cat for the treatment of pruritus. It may also be of benefit as a mild sedative in small animals due to its CNS depressant effects.

Dosage forms

4 to 6 mg PO q4–6h. Maximum daily dose is 24 mg for adults and children 12 years or older. Found frequently in combination with acetaminophen and pseudoephedrine.

Check Digit Verification of cas no

The CAS Registry Mumber 113-92-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 3 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 113-92:
(5*1)+(4*1)+(3*3)+(2*9)+(1*2)=38
38 % 10 = 8
So 113-92-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)

113-92-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (C0873)  Chlorpheniramine Maleate  >99.0%(HPLC)(T)

  • 113-92-8

  • 25g

  • 535.00CNY

  • Detail
  • Alfa Aesar

  • (B25238)  Chlorpheniramine maleate, 99%   

  • 113-92-8

  • 5g

  • 397.0CNY

  • Detail
  • Alfa Aesar

  • (B25238)  Chlorpheniramine maleate, 99%   

  • 113-92-8

  • 25g

  • 915.0CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1016)  Chlorpheniramine Maleate  pharmaceutical secondary standard; traceable to USP, PhEur and BP

  • 113-92-8

  • PHR1016-500MG

  • 732.19CNY

  • Detail
  • Sigma-Aldrich

  • (C1800000)  Chlorphenamine maleate  European Pharmacopoeia (EP) Reference Standard

  • 113-92-8

  • C1800000

  • 1,880.19CNY

  • Detail
  • USP

  • (1123000)  Chlorpheniramine maleate  United States Pharmacopeia (USP) Reference Standard

  • 113-92-8

  • 1123000-125MG

  • 3,720.60CNY

  • Detail
  • Sigma

  • (C3025)  (±)-Chlorpheniramine maleate salt  ≥99% (perchloric acid titration)

  • 113-92-8

  • C3025-5G

  • 322.92CNY

  • Detail
  • Sigma

  • (C3025)  (±)-Chlorpheniramine maleate salt  ≥99% (perchloric acid titration)

  • 113-92-8

  • C3025-25G

  • 804.96CNY

  • Detail
  • Sigma

  • (C3025)  (±)-Chlorpheniramine maleate salt  ≥99% (perchloric acid titration)

  • 113-92-8

  • C3025-100G

  • 2,017.08CNY

  • Detail
  • Cerilliant

  • (C-036)  Chlorpheniramine maleate salt solution  1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material

  • 113-92-8

  • C-036-1ML

  • 263.25CNY

  • Detail

113-92-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Chlorpheniramine maleate

1.2 Other means of identification

Product number -
Other names CHLORPHENAMINE MALEATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:113-92-8 SDS

113-92-8Synthetic route

formic acid
64-18-6

formic acid

Didesmethylchlorpheniramine
20619-13-0

Didesmethylchlorpheniramine

maleic acid
110-16-7

maleic acid

chlorphenamine maleate
113-92-8

chlorphenamine maleate

Conditions
ConditionsYield
Stage #1: formic acid; Didesmethylchlorpheniramine In water; N,N-dimethyl-formamide at 100℃; for 24h;
Stage #2: maleic acid In isopropyl alcohol at 80℃; for 2h;
88.8%
2-(4-chlorobenzyl)pyridine
4350-41-8

2-(4-chlorobenzyl)pyridine

2-(dimethylamino)ethyl chloride
107-99-3

2-(dimethylamino)ethyl chloride

maleic acid
110-16-7

maleic acid

chlorphenamine maleate
113-92-8

chlorphenamine maleate

Conditions
ConditionsYield
Stage #1: 2-(4-chlorobenzyl)pyridine With sodium amide In toluene Reflux;
Stage #2: 2-(dimethylamino)ethyl chloride In toluene for 6h; Reflux;
Stage #3: maleic acid In water
54.4%
Stage #1: 2-(4-chlorobenzyl)pyridine With sodium amide In toluene Reflux;
Stage #2: 2-(dimethylamino)ethyl chloride In toluene for 6h; Reflux;
Stage #3: maleic acid In toluene
22.4 g
p-chlorobenzyl cyanide
140-53-4

p-chlorobenzyl cyanide

chlorphenamine maleate
113-92-8

chlorphenamine maleate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: cobaltocene / 4 h / 150 - 170 °C / Autoclave
2.1: sodium amide / tetrahydrofuran / 1 h / 20 - 25 °C
2.2: 2 h / 30 - 45 °C
3.1: ethanol / 2.5 h / -2 - 0 °C
View Scheme
maleic acid
110-16-7

maleic acid

Chlorpheniramine
132-22-9

Chlorpheniramine

chlorphenamine maleate
113-92-8

chlorphenamine maleate

Conditions
ConditionsYield
In ethanol at -2 - 0℃; for 2.5h;350 g
With pyrographite In ethanol at 80℃; for 1.5h; Temperature; Large scale;
With pyrographite In ethanol at 80℃; for 2h; Temperature;
2-(4-chlorobenzyl)pyridine

2-(4-chlorobenzyl)pyridine

maleic acid
110-16-7

maleic acid

chlorphenamine maleate

chlorphenamine maleate

Conditions
ConditionsYield
Stage #1: 2-(4-chlorobenzyl)pyridine With sodium amide In toluene Reflux;
Stage #2: 2-(N,N-dimethylamino)ethyl bromide In toluene for 6h; Reflux;
Stage #3: maleic acid In toluene
24.1 g
chlorphenamine maleate
113-92-8

chlorphenamine maleate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: manganese; trifluoroacetic acid / acetonitrile / 0.17 h
1.2: 12 h / 30 - 40 °C
2.1: sodium amide / toluene / Reflux
2.2: 6 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: manganese; trifluoroacetic acid / acetonitrile / 0.17 h
1.2: 12 h / 30 - 40 °C
2.1: sodium amide / toluene / Reflux
2.2: 6 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: manganese; trifluoroacetic acid / acetonitrile / 0.17 h
1.2: 12 h / 30 - 40 °C
2.1: sodium amide / toluene / Reflux
2.2: 6 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: manganese; trifluoroacetic acid / acetonitrile / 0.17 h
1.2: 12 h / 30 - 40 °C
2.1: sodium amide / toluene / 0.33 h / 20 °C
2.2: 8 h / Reflux
3.1: water; N,N-dimethyl-formamide / 24 h / 100 °C
3.2: 2 h / 80 °C
View Scheme
1-Chloro-4-(chloromethyl)benzene
104-83-6

1-Chloro-4-(chloromethyl)benzene

chlorphenamine maleate
113-92-8

chlorphenamine maleate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: manganese; trifluoroacetic acid / acetonitrile / 0.17 h
1.2: 12 h / 30 - 40 °C
2.1: sodium amide / toluene / Reflux
2.2: 6 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: manganese; trifluoroacetic acid / acetonitrile / 0.17 h
1.2: 12 h / 30 - 40 °C
2.1: sodium amide / toluene / 0.33 h / 20 °C
2.2: 8 h / Reflux
3.1: water; N,N-dimethyl-formamide / 24 h / 100 °C
3.2: 2 h / 80 °C
View Scheme
4-(2-Pyridinylmethyl)phenylamine
58498-12-7

4-(2-Pyridinylmethyl)phenylamine

chlorphenamine maleate
113-92-8

chlorphenamine maleate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / 0 - 5 °C
1.2: 4 h / 20 °C
2.1: sodium amide / toluene / Reflux
2.2: 6 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / 0 - 5 °C
1.2: 4 h / 20 °C
2.1: sodium amide / toluene / 0.33 h / 20 °C
2.2: 8 h / Reflux
3.1: water; N,N-dimethyl-formamide / 24 h / 100 °C
3.2: 2 h / 80 °C
View Scheme
2-(4-chlorobenzyl)pyridine
4350-41-8

2-(4-chlorobenzyl)pyridine

chlorphenamine maleate
113-92-8

chlorphenamine maleate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium amide / toluene / 0.33 h / 20 °C
1.2: 8 h / Reflux
2.1: water; N,N-dimethyl-formamide / 24 h / 100 °C
2.2: 2 h / 80 °C
View Scheme
potassium pentacyanonitrosylchromate(III) monohydrate

potassium pentacyanonitrosylchromate(III) monohydrate

chlorphenamine maleate
113-92-8

chlorphenamine maleate

{Cr(NO)(CN)2(chloropheniramine maleate)2(H2O)}

{Cr(NO)(CN)2(chloropheniramine maleate)2(H2O)}

Conditions
ConditionsYield
With CH3COOH In acetic acid byproducts: CH3COOK, H2O, HCN; aq. acetic acid; 20-30 min, 80°C; CO2 bubbled (few h) to remove HCN; ppt. filtered, washed (H2O repeatedly; ethanol); dried (vac., over silica gel, room temp., to const. wt.); elem.anal.;55%
cobalt(II) nitrate hexahydrate

cobalt(II) nitrate hexahydrate

salicylaldehyde anthranilic acid
122630-45-9, 150063-91-5, 7361-93-5

salicylaldehyde anthranilic acid

chlorphenamine maleate
113-92-8

chlorphenamine maleate

Co(OC6H4CHNC6H4COO)(C5H4NCH(CH2CH2N(CH3)2)C6H4Cl)(H2O)*(HCCOOH)2
151958-93-9

Co(OC6H4CHNC6H4COO)(C5H4NCH(CH2CH2N(CH3)2)C6H4Cl)(H2O)*(HCCOOH)2

Conditions
ConditionsYield
In ethanol byproducts: HNO3; refluxing ethanolic solns. of metal salt, schiff base and heterocyclic base in 1:1:1 molar ratio for 2-5 h, pptn.; filtn., washing with ethanol, drying in vacuo, elem. anal.;53%
tetracyanodinitrosylmolybdate(0)

tetracyanodinitrosylmolybdate(0)

chlorphenamine maleate
113-92-8

chlorphenamine maleate

Mo(NO)2(CN)2(C5H4NCH(CH2CH2N(CH3)2)C6H4Cl)2*2(CHCOOH)2*2H2O=(Mo(NO)2(CN)2(C16H19N2Cl)2)*((CHCOOH)2)2*2H2O

Mo(NO)2(CN)2(C5H4NCH(CH2CH2N(CH3)2)C6H4Cl)2*2(CHCOOH)2*2H2O=(Mo(NO)2(CN)2(C16H19N2Cl)2)*((CHCOOH)2)2*2H2O

Conditions
ConditionsYield
In water; acetic acid addn. of ligand in a mixt. of water/acetic acid to a filtered aq. soln. of molybdate with shaking, refluxing for 4-5 h over a hot plate at 80°C; filtn. by suction, washing several times with dilute acetic acid, finally with water, drying in vacuo at room temp. to a constant weight, elem. anal.;52%
cobalt(II) nitrate hexahydrate

cobalt(II) nitrate hexahydrate

chlorphenamine maleate
113-92-8

chlorphenamine maleate

2-(salicylideneamino)thiophenol
3449-05-6

2-(salicylideneamino)thiophenol

Co(OC6H4CHNC6H4S)(C5H4NCH(CH2CH2N(CH3)2)C6H4Cl)(H2O)*(HCCOOH)2
151987-76-7

Co(OC6H4CHNC6H4S)(C5H4NCH(CH2CH2N(CH3)2)C6H4Cl)(H2O)*(HCCOOH)2

Conditions
ConditionsYield
In ethanol byproducts: HNO3; refluxing ethanolic solns. of metal salt, schiff base and heterocyclic base in 1:1:1 molar ratio for 2-5 h, pptn.; filtn., washing with ethanol, drying in vacuo, elem. anal.;50%
chlorphenamine maleate
113-92-8

chlorphenamine maleate

A

dextrochlorpheniramine maleate
2438-32-6

dextrochlorpheniramine maleate

B

(-)-Chlorpheniramine maleate
23095-76-3

(-)-Chlorpheniramine maleate

Conditions
ConditionsYield
With sodium dihydrogenphosphate; phosphoric acid In methanol; water pH=2.75; Reagent/catalyst; Ionic liquid; Resolution of racemate;
With maleic anhydride-β-cyclodextrin modified Fe3O4 Resolution of racemate; Optical yield = 13.7 %ee;
With tetramethylammonium hydroxyproline; clindamycin phosphate In methanol; water at 20℃; pH=7.6; pH-value; Solvent; Temperature; Resolution of racemate; enantioselective reaction;
With β‐cyclodextrin In aq. phosphate buffer pH=2.5; Resolution of racemate;
chlorphenamine maleate
113-92-8

chlorphenamine maleate

2C16H19ClN2*2C4H4O4*2Na(1+)*C20H6Br4O5(2-)

2C16H19ClN2*2C4H4O4*2Na(1+)*C20H6Br4O5(2-)

Conditions
ConditionsYield
In water at 23℃; for 0.166667h; pH=3.72; Solvent; pH-value; Temperature;

113-92-8Related news

Characteristic of peroxyoxalate-chemiluminescence intensity in the presence of Chlorpheniramine maleate (cas 113-92-8) and its analytical application08/24/2019

It has been shown that Chlorpheniramine maleate (CPM) increases chemiluminescence intensity of bis-(2,4,6-trichlorophenyl)oxalate (TCPO) with hydrogen peroxide in the presence of biphenylquinoxaline as a fluorophore. In this work, the effect of CPM on the intensity of chemiluminescence (CL) in t...detailed

Original ArticleFormulation design and optimization of novel fast dissolving tablet of Chlorpheniramine maleate (cas 113-92-8) by using lyophilization techniques08/23/2019

Fast dissolving tablets (FDTs) have received more interest in the pharmaceutical industry for those categories of drug which show slow dissolution and less oral bioavailability. Nowadays various technologies have been developed for FDTs with improved patient compliance and convenience. FDTs tabl...detailed

Original articleCompatibility study of paracetamol, Chlorpheniramine maleate (cas 113-92-8) and phenylephrine hydrochloride in physical mixtures08/22/2019

Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterizati...detailed

Solubility of Chlorpheniramine maleate (cas 113-92-8) in supercritical carbon dioxide08/21/2019

Solubility of chlorpheniramine maleate in supercritical carbon dioxide at different temperatures (308–338 K) and pressures (160–400 bar) is measured using static method coupled with gravimetric method. The measured solubility data demonstrated that the solubility of chlorpheniramine maleate wa...detailed

113-92-8Relevant articles and documents

Chlorpheniramine maleate crystal form preparation method

-

Paragraph 0023-0031, (2021/12/07)

The invention discloses a chlorpheniramine maleate crystal form preparation method which is different from an existing crystal form preparation method, wherein two solvents are used in the crystallization process, the impurity content in a finished product is effectively reduced, the yield and the purity are improved, the crystal form is stable, the crystal form cannot be changed due to the change of the solvent proportion, and industrial production is facilitated.

Chlorpheniramine maleate salifying substance and synthesis method and application thereof

-

Paragraph 0024-0035, (2020/08/25)

The invention provides a chlorpheniramine maleate salifying substance and a synthesis method and application thereof. The synthesis method comprises the following steps: weighing the following raw material components in parts by weight: 80-90 parts of maleic acid, 460-530 parts of absolute ethyl alcohol, 190-210 parts of chlorpheniramine hydrolysate, 4-10 parts of activated carbon and the like, then stirring and mixing the weighed raw material components to obtain a preheated mixture, transferring the preheated mixture into a filter pressing kettle, carrying out filter pressing and purification to obtain a filter pressing feed liquid of a crystallization kettle, cooling the filter pressing feed liquid of the crystallization kettle, carrying out centrifugal filtration, flushing by absoluteethyl alcohol after filtration, carrying out centrifugation again to obtain the chlorpheniramine maleate salifying substance. By adopting the synthesis method disclosed by the invention, the purity and the final yield of the synthesized chlorpheniramine maleate salifying substance are improved, and the impurity content of the chlorpheniramine maleate salifying substance is reduced.

A new method for synthesizing of chlorpheniramine maleate (by machine translation)

-

, (2019/11/12)

The invention belongs to the field of organic synthesis of the drug, in particular to a new synthetic method of chlorpheniramine maleate. The invention comprises the following sequence of steps: (1) under acidic conditions, to [...] in cobalt catalyst, in the presence of a [...] and 2 - halo pyridine react, generating 2 - to the benzylic pyridine; (2) 2 - to the benzylic pyridine in under the action of the sodium amide and N, N - dimethyl base halogen ethane reaction, generating the cream, chlorpheniramine and maleic acid and get chlorpheniramine maleate. The method of reaction steps is relatively short, the raw material is cheap, the process is simple, easy to operate, does not need special reaction conditions, therefore is more suitable for industrial production. (by machine translation)

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 113-92-8