1184-78-7Relevant articles and documents
Perry et al.
, p. 4899 (1975)
Ferris et al.
, p. 5270 (1967)
An improved preparation of tertiary amine N-oxides.
Cymerman Craig,Purushothaman
, p. 1721 - 1722 (1970)
-
The observed and calculated 1H and 13C chemical shifts of tertiary amines and their N-oxides
Pohl, Radek,Dracinsky, Martin,Slavetinska, Lenka,Budesinsky, Milos
, p. 320 - 327 (2011)
A series of model tertiary amines were oxidized in situ in an NMR tube to amine N-oxides and their 1H and 13C NMR spectra were recorded. Next, the chemical shifts induced by oxidation (Δλ) were calculated using different GIAO methods investigating the influence of the method [Hartree-Fock (HF), Moeller-Plesset perturbation, density functional theory (DFT)], the functional applied in the DFT (B3LYP, BPW, OPBE, OPW91) and the basis set used [6-31G*, 6-311G**, 6-311 + + G** and 6-311 + + G(3df,3pd)]. The best results were obtained with the HF/6-311 + + G** and OPBE/6-311 + + G** methods. The computation/experiment comparison approach was used for the configuration prediction of chiral amine N-oxides-(R) and (S)-agroclavine-6-N-oxide.
Infrared matrix isolation studies of the trimethylamine oxide-hydrogen chloride complex
Mielke, Z.
, p. 673 - 676 (1986)
The reaction products of the codeposition of trimethylamine oxide and a HCl/Ar mixture are characterized by diffuse absorption in the region from 1850 to ca 3200 cm-1 and by a strong band at 1700 cm-1.These absorptions are assigned respectively to the O-H+ ...Cl- antisymmetric stretching and in-plane bending modes, which indicates that proton transfer to basic oxygen occurs.
SO2F2-mediated oxidation of primary and tertiary amines with 30% aqueous H2O2 solution
Liao, Xudong,Zhou, Yi,Ai, Chengmei,Ye, Cuijiao,Chen, Guanghui,Yan, Zhaohua,Lin, Sen
supporting information, (2021/11/01)
A highly efficient and selective oxidation of primary and tertiary amines employing SO2F2/H2O2/base system was described. Anilines were converted to the corresponding azoxybenzenes, while primary benzylamines were transformed into nitriles and secondary benzylamines were rearranged to amides. For tertiary amine substrates quinolines, isoquinolines and pyridines, their oxidation products were the corresponding N-oxides. The reaction conditions are very mild and just involve SO2F2, amines, 30% aqueous H2O2 solution, and inorganic base at room temperature. One unique advantage is that this oxidation system is just composed of inexpensive inorganic compounds without the use of any metal and organic compounds.
PYRAZOLE DERIVATIVES AND USES THEREOF AS INHIBITORS OF DLK
-
Page/Page column 115, (2015/07/07)
The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various embodiments thereof. In compounds of formula 0, the groups R1A, R1B, R1C, R1D, R2, R3, R4, R5 and R6 have the meaning as described herein. The present invention also provides for methods of using compounds of formula 0 and compositions comprising compounds of formula 0 as DLK inhibitors and for treating neurodegeneration diseases and disorders.
