121638-36-6Relevant articles and documents
Palladium/TY-Phos-Catalyzed Asymmetric Intermolecular α-Arylation of Aldehydes with Aryl Bromides
Li, Wenbo,Liu, Feng,Pan, Zhangjin,Wu, Hai-Hong,Zhang, Junliang,Zhu, Shuai
supporting information, p. 18542 - 18546 (2021/07/21)
Despite much progress has been made in the asymmetric α-arylation reactions of cyclic ketones, lactones and lactams, the enantioselective α-arylation of acyclic carbonyl compounds lagged much behind due to the in situ generated Z/E-enolate intermediates l
Darifenacin intermediate 2, 3 - dihydro - 5 - benzofuran acetic acid preparation new method of (by machine translation)
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, (2018/04/03)
The invention relates to a darifenacin intermediate - 2, 3 - dihydro - 5 - benzofuran acetic acid. By the P-hydroxy-acetic acid and bromo acetaldehyde acetal as the starting material, the presence of O - alkylation reaction under a condition of the corresponding ether compound; then by esterification reaction to obtain the corresponding ester; in PPA (poly phosphoric acid) under the action of the, cyclization to obtain 2, 3 - benzofuran - 5 - acetate; 2, 3 - benzofuran - 5 - acetic acid layer which hydrolysis, to acidify the corresponding carboxylic acid; obtained by catalytic hydrogenation of 2, 3 - dihydro - 5 - benzofuran acetic acid; or the first 2, 3 - benzofuran - 5 - acetate obtained by catalytic hydrogenation of 2, 3 - dihydro - 5 - benzofuran acetic acid esters; and hydrolyzed, acidified to obtain 2, 3 - dihydro - 5 - benzofuran acetic acid. The method of the invention by simple and safe, each reaction raw materials are cheap and easy to obtain, the reaction yield is high, and is particularly suitable for industrial production of 2, 3 - dihydro - 5 - benzofuran acetic acid. (by machine translation)
Monospecific antibodies useful in evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones
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, (2008/06/13)
Inhibitors of human leukocytes elastase are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases. In inhibiting elastase, the therapeutic agents are shown to form a characteristic stable complex with the enzyme. In the radioimmunoassay disclosed herein, the inhibitor-enzyme complex is advantageously hydrolyzed and specific product(s) of the hydrolysis are measured utilizing polyclonal antibodies capable of binding to one or more haptens of formula II STR1 wherein M is allyl or n-propyl, Z1 is (a) 5-benzofuranyl or (b) substituted phenyl wherein the substituent is methyl or ethyloxy. The assays utilizing these antibodies are useful in a clinical setting, for determining appropriate dosage and assessing the effectiveness of treatment.
PREPARATION AND CYCLIZATION OF ARYLOXYACETALDEHYDE ACETALS; A GENERAL SYNTHESIS OF 2,3-UNSUBSTITUTED BENZOFURANS
Barker, Peter,Finke, Paul,Thompson, Kevan
, p. 257 - 266 (2007/10/02)
A improved method for the preparation of 2,3-unsubstituted benzofurans is described.Specifically, the PPA catalysed cyclization of aryloxyacetaldehyde acetals to give (4-7)-substituted benzofurans has been achieved.
