123-90-0 Usage
Description
Thiomorpholine is a saturated organic heteromonocyclic compound that is an analogue of morpholine, where the oxygen atom is replaced by sulfur. It forms complexes with Cu(II), Pt(II), and Ni(II) salts, and its chemical properties include being a clear colorless to yellow liquid.
Uses
Used in Organic Synthesis:
Thiomorpholine is used as an intermediate in the synthesis of various organic compounds, contributing to the development of pharmaceuticals and other chemical products.
Used in Pharmaceutical Industry:
Thiomorpholine is used as an intermediate for blonanserin, a medication used to treat schizophrenia.
Used in Antimicrobial Applications:
In the preparation of pyrrole derivatives, Thiomorpholine acts as an antimycobacterial agent, helping to combat mycobacterial infections.
Used in Hypocholesterolemic Activity:
Thiomorpholine is involved in hypocholesterolemic activity, potentially contributing to the development of treatments for high cholesterol levels.
Purification Methods
Purify it by vacuum distillation. The hydrochloride has m 179o (from isoPrOH or EtOH/Et2O/HCl). [Davies J Chem Soc 306 1920, Beilstein 27 II 4, 2 III/IV 636.]
Check Digit Verification of cas no
The CAS Registry Mumber 123-90-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 123-90:
(5*1)+(4*2)+(3*3)+(2*9)+(1*0)=40
40 % 10 = 0
So 123-90-0 is a valid CAS Registry Number.
InChI:InChI=1/C4H9NS/c1-3-6-4-2-5-1/h5H,1-4H2/p+1
123-90-0Relevant articles and documents
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Duty,Milewski
, p. 2453 (1973)
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Preparation and chemical properties of 5-dialkylaminomethylhydantoins and 2-thio-analogues
Fujisaki, Fumiko,Shoji, Kaori,Sumoto, Kunihiro
experimental part, p. 1415 - 1420 (2010/04/29)
An efficient procedure for the preparation of 5- dialkylaminomethylhydantoins 3, which are easily obtained from cyclization of the corresponding urea derivatives 2 starting with β-aminoalanines 1, is described. Methylenehydantoin and the corresponding 2-t
An annulation reaction for the synthesis of morpholines, thiomorpholines, and piperazines from β-heteroatom amino compounds and vinyl sulfonium salts
Yar, Muhammad,McGarrigle, Eoghan M.,Aggarwal, Varinder K.
, p. 3784 - 3786 (2008/12/23)
(Chemical Equation Presented) Heterocycling: Diphenyl vinyl sulfonium salt 1 acts first as an electrophile, then a base, and then again as an electrophile in this operationally simple, high yielding, one-pot synthesis of pharmacologically important morpholines, thiomorpholines, and piperazines. Compound 1 is an excellent synthon for the 1,2-ethane dication.