13681-87-3Relevant articles and documents
Mechanically activated solid-phase synthesis of copper(II), zinc(II), and cadmium(II) diethyldithiocarbamates
Petrova,Makhaev
, p. 865 - 870 (2007)
The mechanically activated solid-phase reaction of copper, zinc, and cadmium chlorides with sodium diethyldithiocarbamate is studied. The course of the process and the extent of reaction are studied as affected by the parameters of the mechanical activati
Fourier Transform Infrared and Raman spectra, DFT: B3LYP/6-311G(d, p) calculations and structural properties of bis(diethyldithiocarbamate)copper(II)
Costa Jr.,Ramos,Tellez Soto,Martin,Raniero,Ondar,Versiane,Moraes
, p. 259 - 266 (2013)
Theoretical and experimental bands have been assigned for the Fourier Transform Infrared (FT-IR) and FT-Raman spectra of the bis(diethydithiocarbamate)Cu(II) complex, [Cu(DDTC)2]. The calculations and spectra interpretation have been based on the DFT/B3LYP method, infrared and Raman second derivative spectra, and band deconvolution analysis. To better assign the metal-ligand normal modes in the spectral region of low energy, the deviation percentage of the geometrical parameters was used, with values from the interpretation of the normal modes of L matrix. Results indicate a planar structure around the Cu(II) cation. The calculated infrared and Raman spectra, based on the proposed geometrical structure of the bis(diethyldithiocarbamate)copper(II) complex, agreed with the experimental spectra.
Antioxidant potential and secondary reactivity of bisfdiphenyl(2-pyridyl)phosphinogcopper(II) complex
Khan, Ezzat,Shahzad, Adnan,Tahir, Muhammad Nawaz,Noor, Awal
, p. 1299 - 1308 (2018)
Copper-based complexes with the general formulas [Cu(L)2]Cl2(1) and [Cu2L2 (μ2-L)μ2-Cl2](2) and a mixed-ligand anionic complex [Cu(L)2 dedtc][LCl] (3b), where L = diphenyl(2-pyridyl)phosphine and dedtc = diethyldithiocarbamate, were synthesized and structurally characterized. X-ray analysis revealed that the coordination environment around the copper atom in complexes 1-3 is distorted tetrahedral. In monomeric complexes 1 and 3b both diphenyl(2-pyridyl) phosphine ligands are monodentate and are coordinated through the P-atom. In complex 3b two phosphine ligands are attached to copper through the P-atom. The third phosphine ligand acts as a bridged ligand, coordinated to the metal centers through the P-atom and N-atom. Complexes 1 and 3b were tested for radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) as a free radical. A prominent color change after mixing the solution of complex 1 and DPPH was observed, indicating the efficiency of the compound as antioxidant.
Stability of diethyl dithiocarbamate chelates with Cu(II), Zn(II) and Mn(II)
Liu, Wengang,Duan, Hao,Wei, Dezhou,Cui, Baoyu,Wang, Xinyang
, p. 375 - 381 (2019)
Immobilization has been regarded as one of the most effective technology to eliminate heavy metals contamination. However, the stability of immobilization products and the leakage of immobilized heavy metals impeded its further application. In order to depict the stability of chelating complexes C10H20MnN2S4, C10H20CuN2S4 and C10H20ZnN2S4, DSC-TG analysis, DFT calculation and leakage tests were carried out to reveal the stabilities and the potential leakage risks of immobilized heavy metals when sodium diethyl dithiocarbamate was used as soil amendments. The results indicated that the stability of these three chelating complexes was ranked in the order of C10H20CuN2S4> C10H20ZnN2S4> C10H20MnN2S4. Such precipitations as C10H20MnN2S4, C10H20CuN2S4 and C10H20ZnN2S4 were stable under the neutral and alkaline environment. Meanwhile, leakage of immobilized heavy metals decreased with the increasing leaching pH, whereas time and temperature had no significant impact on the leakage of immobilized heavy metals. And the maximum leakage of immobilized heavy metals was lower than the limited concentration.
Disulfiram and Its Copper Chelate Attenuate Cisplatin-Induced Acute Nephrotoxicity in Rats Via Reduction of Oxidative Stress and Inflammation
Khairnar, Shraddha I.,Mahajan, Umesh B.,Patil, Kalpesh R.,Patel, Harun M.,Shinde, Sachin D.,Goyal, Sameer N.,Belemkar, Sateesh,Ojha, Shreesh,Patil, Chandragouda R.
, p. 174 - 184 (2020)
The use of cisplatin (CP) in chemotherapy of resistant cancers is limited due to its dose-dependent nephrotoxicity. Disulfiram (DSF), the aversion therapy for alcoholism, has recently emerged as an anticancer and chemopreventive agent. Its anticancer activity is potentiated in the presence of copper. However, such use of copper leads to several adverse effects. In the present study, the protective effect of DSF and its copper chelate (Cu-DEDC) against CP-induced nephrotoxicity in rats was evaluated. Nephrotoxicity was induced by a single intraperitoneal injection of CP (5?mg/kg). The treatment groups included control (vehicle treated), CP (CP-treated), CP + DSF (CP followed by DSF), CP + DSF + Cu (CP followed by DSF and CuCl2), CP + Cu-DEDC (CP followed by Cu-DEDC), and CP + AMF (amifostine pre-treated and CP-treated). The DSF, Cu-DEDC, and CuCl2 were administered orally at 50?mM/kg/day dose for 5?days post CP injection. AMF served as a standard chemo protectant, administered intravenously 30?min prior to CP. The markers of oxidative stress, inflammation, and kidney function estimated on the 6th day revealed that both DSF and Cu-DEDC significantly attenuated the CP-induced rise in the serum/urine creatinine and blood urea nitrogen (BUN). The CP-induced rise in serum alkaline phosphatase (ALPase) was reversed by these drugs. Both drugs reduced the levels of malondialdehyde and nitric oxide (NO) in kidney tissues. These drugs reversed CP-induced depletion of SOD, catalase, and GSH in the kidneys. There was a significant reduction in the CP-induced TNF-α and IL-1β production along with prevention of histological alterations. Above observations indicate that DSF and Cu-DEDC may have significance as adjuvants to protect against CP-induced nephrotoxicity.
Magnetic and Structural Studies on Copper(II) Dialkyldithiocarbamates
Boyd, Peter D. W.,Mitra, Samaresh,Raston, Colin L.,Rowbottom, Graham L.,White, Allan H.
, p. 13 - 22 (1981)
The magnetic susceptibilities of a series of copper(II) dialkyldithiocarbamates have been measured over the range 4-290 K, the alkyl groups being methyl, ethyl, isopropyl, and n-butyl.Contrary to a previous report of strong ferromagnetic interaction in the diethyl derivative, we find no evidence of any significant exchange interaction in this compound.The dimethyl and di-isopropyl analogues show weak antiferromagnetic interactions.Only the di-n-butyl derivative in the dialkyl series shows evidence of strong magnetic exchange interaction but of an antiferromagnetic nature; this effect is peculiar to the phase recrystallized from chloroform-light petroleum (α), the phase obtained from chloroform-ethanol (β) showing no such interaction.To seek the origin of the exchange interaction in the α derivative, its crystal structure has been determined by single-crystal X-ray diffraction methods at 295 K and refined by least squares to a residual 0.032 for 1976 'observed' reflections.Crystals are triclinic, P1, a=15.29(1), b=9.963(7), c=9.243(7) Angstroem, α=67.94(7), β=82.92(7), γ=71.55(7) deg, and Z=2.The copper environment is the usual pseudo-square-planar array of four sulphur atoms from two bidentate ligands (, 2.31 Angstroem), but there is a long fifth interaction S, 2.899(4) Angstroem> through the inversion centre leading to pseudo-dimer formation.Although similar to the diethyl analogue in this respect, differences are observed in regard to (a) the bridging geometry in the 'dimer' and (b) the proximity to the 'dimer' sulphur ligands of sulphur atoms from neighbouring dimers at ca. 3.8 Angstroem.The likely relative importance of these two features in determining the origin of the antiferromagnetic coupling is discussed.The structure of the β phase has also been determined, the final residual being 0.036 for 1324 'observed' reflections.Crystals are monoclinic, P21/n, a= 14.593(5), b= 7.840(2), c= 10.822(5) Angstroem, β= 101.55(3) deg, and Z= 2.The molecules are located with the copper atoms on crystallographic centres of symmetry, and the only significant intermolecular interactions observed are SH contacts.The CuS4 entity is planar with 2.30 Angstroem.
Charge-transfer photochemistry of copper(II) dithiocarbamate mixed-ligand complexes
Jeliazkova,Doicheva
, p. 1277 - 1282 (1996)
The photoredox behaviour of copper(II) diethyldithiocarbamate mixed-ligand complexes, Cu(Et2dtc)X (X = Cl, ClO4, NO3), is characterized by strongly allowed ligand-to-metal charge transfer (LMCT) transition in the visible s
Efficient solar light Driven photocatalytic degradation of congo red dye on CdS nanostructures derived from single source precursor
Nasir, Jamal Abdul,Gul, Shaheen,Khan, Azam,Shah, Zawar Hussain,Ahmad, Abrar,Zulfiqar,Khan, Rajwali,Liu, Zhongxin,Chen, Wei,Lin, Dan-Jae,Zia-ur-Rehman
, p. 7405 - 7413 (2018)
This article presents a facile synthesis of cadmium sulfide nanorods (CdS-NR) and nanospheres (CdS-NS) using cadmium(II) dithiocarbamate as a precursor in the presence of two different ther-malizing solvents {ethylenediamine (en) and octylamine (OA)}. The as-synthesized CdS-NR and CdS-NS were characterizedby powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), selected area electron diffraction technique (SAED), fourier transmission infrared spectroscopy (FTIR), energy dispersive X-ray spectroscopy (EDS), UV-visible spectroscopy, steady-state and time resolved photoluminesce (PL). TEM analysis has confirmed the formation of nanorods and nanospheres in the presence of en and OA, respectively. The in situ generated different capping ligands, as confirmed by FT-IR analysis, may be responsible for variation in morphology. The XRD results revealed hexagonal (nanorods) and cubic mixed hexagonal phase (nanospheres). Owing to band gapes (UV-Vis) in the visible region, both these nanostructures (nanorods and nanospheres) were tested as a solar light drive photocatalyst for the degradation of Congo red (CR). The results indicated that CdS-NR exhibit better catalytic efficiency (Kapp = 0.366 min?1 toward CR degradation as compared to CdS-NS (Kapp = 0.299 min?1. The better photocatalytic activity of nanorods can be attributed to the anisotropically grown structure which infers longer electron hole recombination time as revealed by the time resolved PL.
On the interaction of copper(ii) with disulfiram
Lewis, David J.,Deshmukh, Parikshit,Tedstone, Aleksander A.,Tuna, Floriana,O'Brien, Paul
, p. 13334 - 13337 (2014)
In combination with copper(ii) ions, disulfiram (DSF) has been reported to be a potentially potent anticancer agent based on in vitro results. The interaction of DSF with copper(ii) chloride in solution has been studied using a range of spectroscopic techniques. There is strong evidence for the rapid formation of the bis(N,N-diethyl dithiocarbamato)copper(ii) complex in situ. Kinetic experiments were used to determine rate laws for the reaction that give insight into the mechanism of the process which may help to explain the observed in vitro cytotoxicity. This journal is
Trivalent copper and indium heterometallic complex with dithiocarbamate and iodide ligands
Lee, Hyun?Jong,Jung, Seonho,Cha, Ji?Hyun,Nam, Dongsik,Choe, Wonyoung,Jung, Duk?Young
, (2020)
The heterometallic Cu–In complex salt [Cu(III) (dtc)2][In(III)I4](1) (dtc = S2CNEt2, diethyldithiocarbamate) was prepared by reactions of Cu(II) (dtc)2 and In(III)I3 in benzene solution. As a redox reaction, Cu(II) (dtc)2 was oxidized to [Cu(III) (dtc)2]+, and In(III)I3 was changed to [In(III)I4]?. The square?planar Cu(III)S4 local symmetry of 1 involves a distorted octahedral coordination environment via long?range intermolecular interactions and represents a new one-dimensional structure of [Cu(III) (dtc)2]+ units. The crystal packing system of 1 consists of many [Cu(III) (dtc)2]+ chains surrounded by six parallel chains without solvent molecules. The infrared spectra of 1 showed a higher-frequency C–N thioureide bond in Cu(III) (dtc)2 than that of pristine Cu(II) (dtc)2, which has a lower oxidation state due to the Cu(II) center.
